A5034979884- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Body Composition Measurement Techniques
- Migraine and Headache Studies
- Eosinophilic Esophagitis
- Sports Performance and Training
- Colorectal Cancer Screening and Detection
- Thermoregulation and physiological responses
- Blood disorders and treatments
- Gastric Cancer Management and Outcomes
- Cardiovascular and exercise physiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Parkinson's Disease Mechanisms and Treatments
- Abdominal Surgery and Complications
- Cardiac Health and Mental Health
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Pneumonia and Respiratory Infections
- Urinary Tract Infections Management
- Fermentation and Sensory Analysis
- Ear Surgery and Otitis Media
- Amyotrophic Lateral Sclerosis Research
- Immunodeficiency and Autoimmune Disorders
- Trigeminal Neuralgia and Treatments
- Neurogenetic and Muscular Disorders Research
Tampa General Hospital
2018-2024
Sarasota Memorial Hospital
2018
St. Michael's Hospital
2017-2018
British Heart Foundation
2018
University of Toronto
1974-2017
Allina Health
2017
United Hospital
2017
Ministry of Health and Long Term Care
2017
McMaster University
1998-2016
University of Cambridge
2015
Rizatriptan (MAXALT(TM), Merck & Co., Inc.) is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action for the acute treatment migraine. This randomized, double-masked, double-dummy, placebo-controlled study compared rizatriptan 10 mg to naratriptan (NARAMIG(TM), AMERGE(TM), both Glaxo Wellcome plc) 2.5 in 522 patients treating single migraine attack. was more effective than naratriptan. provided earlier headache relief (hazard ratio 1.62, p < 0.001),...
A randomized controlled trial conducted in patients with gastroesophageal reflux disease compared optimized medical therapy using proton pump inhibitor (n = 52) laparoscopic Nissen fundoplication 52). Patients were monitored for 1 year. The primary end point was frequency of dis-ease symptoms. Surgical had improved symptoms, pH control, and overall quality life health index after surgery at year the group. symptom score unchanged patients, but surgical patients. Fourteen arm experienced...
<h3>Introduction</h3> Inherited bone marrow failure syndromes (IBMFSs) often have substantial phenotypic overlap, thus genotyping is critical for establishing a diagnosis. <h3>Objectives and methods</h3> To determine the genetic characteristics mutation profiles of IBMFSs, comprehensive population-based study that prospectively enrols all typical atypical cases without bias required. The Canadian Marrow Failure Study such study, was used to extract clinical information patients enrolled up...
To provide a comprehensive follow-up of 381 patients after laparoscopic Nissen fundoplication (LNF) using technique minimal paraesophageal dissection.Patients underwent 24-hour pH recording, esophageal manometry, and symptom score assessment for six symptoms gastroesophageal reflux disease preoperatively. date, 260 have undergone repeat studies at 6 months 108 2 years.LNF was associated with significant (p < 0.0001) increase in the lower sphincter (LES) pressure drop duration acid 24 hours...
Hashmi SK, Allen C, Klaassen R, Fernandez CV, Yanofsky Shereck E, Champagne J, Silva M, Lipton JH, Brossard Samson Y, Abish S, Steele Ali K, Dower N, Athale U, Jardine L, Hand JP, Beyene Dror Y. Comparative analysis of Shwachman-Diamond syndrome to other inherited bone marrow failure syndromes and genotype–phenotype correlation. Our knowledge the phenotypes (IBMFSs) derives from case reports or series in which only one IBMFS was studied. However, substantial phenotypic overlap necessitates...
Soluble TRAIL (s ) can be produced by myeloid‐derived cells to kill cancer cells. Whether this mechanism is used T cells, and if so, how sTRAIL production regulated, remains unclear. Our previous studies showed that ex vivo expanded human γδ express NK receptor group 2 (R2), member D ( NKG ), possess potent anticancer activities both in vitro vivo. Here, we investigated greater detail the mechanisms which utilize lung We demonstrate R ligands. Blocking or during ‐cell‐lung cell co‐cultures...
Rizatriptan is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment migraine. This randomized double- blind crossover outpatient study assessed preference for 1 rizatriptan 10 mg tablet to 2 ergotamine mg/caffeine 100 tablets 439 patients treating single migraine attack each therapy. Of expressing (89.1%), more than twice as many preferred ergotamine/caffeine (69.9 vs. 30.1%, p < or = 0.001). Faster relief headache was most...
Up to 50% of patients with amyotrophic lateral sclerosis (ALS) show mild moderate cognitive-behavioural change alongside their progressive functional impairment. This study examines the relative impact patients' disease symptoms, behavioural and current executive function social cognition abilities on psychosocial outcomes in spouse caregivers people ALS. Thirty-five rated own levels depression anxiety, subjective burden marital satisfaction. Caregivers also partner's everyday behaviour. The...
Barth syndrome (BTHS), a rare, X-linked, recessive disease, is characterized by neutropenia and cardiomyopathy. BTHS caused loss-of-function mutations of the tafazzin (TAZ) gene. We developed model transfecting human HL60 myeloid progenitor cells with TAZ-specific shRNAs. Results demonstrate significant downregulation in TAZ expression, mimicking effects naturally occurring truncation TAZ. Flow cytometry analyses TAZ-specific, but not scrambled, shRNAs nearly twofold increase proportion...
This paper reports an analysis of two randomized controlled trials rizatriptan, in which the 24-h Migraine Quality Life Questionnaire © was used to assess migraine-specific quality life patients receiving acute treatment. The objective determine clinical effects a migraine medication, as measured by traditional trial endpoints, contribute better short-term health-related life. results demonstrate that who experience complete pain relief and are able function at their normal ability within 2...
Asthma is among the most common chronic diseases in adults. International guidelines have emphasized importance of regular spirometry for asthma control evaluation. However, use primary care remains low across jurisdictions. We sought to design and evaluate a knowledge translation intervention address both poor quality underuse care.We designed 1-year consisting initial interactive education hands-on training followed by unstructured peer expert mentoring (through an online portal, email,...
A 55 year old runner covered 160 km within a 20 hour period. His speed averaged 8.16 km/h, at an estimated 59.1% of maximum oxygen intake. After the first four hours running, one five fluids was taken in rotation every twelve minutes. Volumes ingested whe heart rate for final (125/min) not increased relative to consumption this portion run. Constancy rate, continued urine production and formal fluid balance calculations all indicate that hydration well maintained over Caloric intake 480...
Fifty-five soldiers have been observed over a vigorous 10-day sledging patrol in the Canadian arctic and subarctic. Initial observations showed low level of physical fitness (26% body fat, aerobic power 41.9 ± 7.8 ml kg −1 min , handgrip force 43.7 7.2 kg). Over 2-week northern sojourn, energy expenditures as measured by Kofranyi–Michaelis respirometer diary observation averaged 3248 kcal (13.6 MJ) day with small (152 (633 kJ)) positive daily balance. A weight loss 1 kg, presumably water,...