Zachary A. Buchholtz
A5072711520- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Impact on Reproduction
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Neonatal and fetal brain pathology
- Cardiovascular and Diving-Related Complications
- High Altitude and Hypoxia
Mayo Clinic in Arizona
2020-2023
Mayo Clinic
2021-2023
WinnMed
2021
The United States (US) Expanded Access Program (EAP) to coronavirus disease 2019 (COVID-19) convalescent plasma was initiated in response the rapid spread of severe acute respiratory syndrome 2 (SARS-CoV-2), causative agent COVID-19. While randomized clinical trials were various stages development and enrollment, there an urgent need for widespread access potential therapeutic agents. objective this study is report on demographic, geographical, chronological characteristics patients EAP, key...
Abstract Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests immunological differences may impact effectiveness of antibody-based treatments such convalescent plasma vaccines. Considering near-sourced likely reflects antigenic composition local viral strains, we hypothesize has a higher efficacy, defined by...
INTRODUCTION: Exposure to low oxygen environments (hypoxia) can impair cognitive function; however, the time-course of transient changes in function is unknown. In this study, we assessed with a test before, during, and after exposure hypoxia. METHODS: Nine participants (28 4 yr, 7 women) completed Conners Continuous Performance Test (CCPT-II) during three sequential conditions: 1) baseline breathing room air (fraction inspired oxygen, F I o 2 0.21); 2) acute hypoxia (F 0.118); 3) recovery...
Abstract Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests immunological differences may impact effectiveness of antibody-based treatments such convalescent plasma vaccines. Considering near-sourced is likely reflect antigenic composition local viral strains, we hypothesized has a higher efficacy, defined by...
Background Cognitive deficits resulting from mild hypoxia are difficult to quantify and reproduce consistently. The changes in executive function during acute still controversial. purpose of present study was assess moderate using a continuous performance test (Connors’ Continuous Performance test, CCPT‐II). Methods Nine young, healthy adults (7 women; 28 ± 1 years; BMI: 24.5 3.0 kg·m −2 ) performed two sets CCPT‐II different conditions: 1) 7 minutes baseline (fraction inspired oxygen (F i O...