A5088183107- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Crystallization and Solubility Studies
- Lipid Membrane Structure and Behavior
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical studies and practices
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Drug Transport and Resistance Mechanisms
- Essential Oils and Antimicrobial Activity
- Liver Disease Diagnosis and Treatment
- Surfactants and Colloidal Systems
- Drug-Induced Hepatotoxicity and Protection
- Dermatology and Skin Diseases
- Dendrimers and Hyperbranched Polymers
- Microencapsulation and Drying Processes
- Carbon dioxide utilization in catalysis
- Antimicrobial agents and applications
- Viral gastroenteritis research and epidemiology
Bharati Vidyapeeth Deemed University
2016-2025
Savitribai Phule Pune University
2005-2016
National Chemical Laboratory
1995-2010
National Centre for Cell Science
2010
Nanomaterials have gained tremendous importance in biology and medicine because they can be used as carriers for delivering small molecules such drugs, proteins, genes. We report herein the binding of hormone insulin to gold nanoparticles its application transmucosal delivery therapeutic treatment diabetes mellitus. Insulin was loaded onto bare aspartic acid-capped delivered diabetic Wistar rats by both oral intranasal (transmucosal) routes. Our principle observations are that there is a...
Abstract “Gellan Gum”, widely used in food and confectionary industry as a thickening gelling agent, has been employed reducing stabilizing agent for the synthesis of gold nanoparticles. These nanoparticles display greater stability to electrolyte addition pH changes relative traditional citrate borohydride reduced Subsequently these have load anthracycline ring antibiotic doxorubicin hydrochloride. The drug loaded on showed enhanced cytotoxic effects human glioma cell lines LN‐18 LN‐229.
Galangin possess wide range of pharmacological activities including antiarthritic, hepatoprotective, anti-inflammatory, antibacterial, and anticancer especially in hepatocellular carcinoma. However, its biological use has been limited owing to poor aqueous solubility, P-gp efflux rapid vivo metabolism by cytochrome enzymes. In order address the drawbacks galangin, current work was designed with an objective prepare liver targeted galangin loaded galactosylated pluronic F68 polymeric...
Biocompatible gold nanoparticles were synthesized by using a naturally occurring gum--Gellan Gum--as capping and reducing agent. These further conjugated with sophorolipids which again accessed through biochemical transformation of fatty acid. The cellular uptake sophorolipid-conjugated gellan gum reduced their cytotoxicity on human glioma cell line LN-229 stem HNGC-2 investigated. Quite surprisingly even the simple reduced/capped showed greater efficacy in killing lines and, gratifyingly,...
The objective of the present investigation was to study effect polyethylene glycol 4000 (PEG 4000) on in vitro dissolution gliclazide from solid dispersions. Initial studies were carried out using physical mixtures drug and carrier. Solid dispersions prepared by melting or fusion method.Phase saturation solubility study, pure drug, out. PEG found be effective increasing when compared drug. FT-IR spectroscopy, differential scanning calorimetry X-ray diffractometry order characterize...
ABSTRACT Currently gold nanoparticles are being explored for drug delivery and other biomedical applications; therefore it is necessary to study the fate of such inside body. The objective present was investigate cellular uptake toxicity synthesized using a microbial polysaccharide, gellan gum, as capping reducing agent. studied on mouse embryonic fibroblast cells, NIH3T3 human glioma cell line, LN‐229. indicated that gum‐reduced were located in cancer cells (LN‐229) while no observed normal...
Context: The current work was carried out by exploring the principles of quality design approach to develop an optimized nanostructured lipid carrier (NLC) formulation poorly water soluble active iloperidone (ILO) through systematic statistical study. potential NLC for improving oral bioavailability ILO also evaluated.Objective: To understand effect variables (critical parameters) on performance characteristics attributes) NLC.Materials and methods: A 3-factor, 3-level Box–Behnken factorial...
The preparation of highly stable water dispersions silver nanoparticles using the naturally available gellan gum as a reducing and capping agent is reported. Further, exploiting gel formation characteristic nanoparticle incorporated gels have also been prepared. optical properties, morphology, zeta potential long-term stability synthesized were investigated. superior gum-silver against pH variation electrolyte addition revealed. Finally, we studied cytotoxicity AgNP in mouse embryonic...