Galangin possess wide range of pharmacological activities including antiarthritic, hepatoprotective, anti-inflammatory, antibacterial, and anticancer especially in hepatocellular carcinoma. However, its biological use has been limited owing to poor aqueous solubility, P-gp efflux rapid vivo metabolism by cytochrome enzymes. In order address the drawbacks galangin, current work was designed with an objective prepare liver targeted galangin loaded galactosylated pluronic F68 polymeric...

The present work reports preparation of irbesartan (IBS) loaded nanofibre mats using electrospinning technique. prepared nanofibres were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, differential calorimetry, X-ray diffraction analysis, in vitro diffusion and ex vivo skin permeation studies. FTIR studies revealed chemical compatibility IBS polyvinyl pyrrolidine (PVP K-30). SEM images confirmed formation wherein existed amorphous form as DSC XRD...

Propolis is a multicomponent active, complex resinous substance collected by honeybees (Apis mellifera) from variety of plant sources. This study was designed to improve the antimicrobial efficacy propolis engineering niosomal-based system for topical application. extracted in ethanol and screened total polyphenol content. Propolis-loaded niosomes (PLNs) were prepared with varying concentrations Span 60 cholesterol. The PLNs evaluated physicochemical parameters, namely, vesicle size,...

Chrysin (CH), a phytoconstituent has numerous pharmacological activities including anticancer activity. However, CH suffers from drawback of poor aqueous solubility and in turn bioavailability limiting its clinical utility. In this work loaded folate-conjugated pluronic PF127-pluronic F68 mixed micelles were prepared with an objective to augment oral cytotoxicity human breast cancer cell line MCF-7 by active targeting mechanism. Folate-conjugated PF127 was synthesized used for preparation...

The deadly parasite disease known as visceral leishmaniasis (VL) is caused by the protozoa of Leishmania donovani. Artesunate (ART) has been reported to act against VL. However its medical...

The objective of the current paper was to screen potential electrospray technique for synthesis cocrystals from a most challenging caffeine (CA)/maleic acid (MA) pair. Additionally, influence solvent properties on formation cocrystal form also investigated. CA and MA were dissolved in sufficient amount methanol, ethyl acetate, acetone, water separately so as obtain 1:1 2:1 equimolar ratios. prepared solutions electrosprayed at voltage 20 kV. formed these solvents with diverse physicochemical...

Six acidic coformers were used to prepare eutectics of rivaroxaban (RXB), a factor Xa inhibitor. The displayed improved solubility, dissolution rate, and bioavailability RXB, without compromising on its stability.

Most of the active pharmaceutical ingredients (APIs) suffer from a drawback poor aqueous solubility. In addition to same, some APIs show tabletting behavior creating problems in formulation development. Crystal engineering can be an efficient tool rectification such associated with APIs. Thus present work deals crystallization ibuprofen (a model drug) onto surface dicalcium phosphate (DCP) particles using different techniques.The objective was prepare ibuprofen-loaded DCP and further analyze...

Harmine (HM), a phytoconstituent has wide range of pharmacological activities including antimicrobial, antifungal, antioxidative, and anticancer. HM shown promising anticancer activity against liver cancer cells. However, poor aqueous solubility, multidrug pump P-gp efflux, extensive in vivo metabolism, rapid elimination due to glucuronidation/sulfation limit clinical utility HM. In order overcome the drawbacks HM, current work reports preparation HM-loaded galactosylated pluronic F-68...

The present study was planned to investigate the effect of absorption enhancers on microstructure Losartan potassium gel and hence its influence diffusion across nasal mucosa.Losartan loaded carbopol (1% w/v) with without prepared. Polyethylene glycol (PEG) 4000 ethanol were used as enhancers. Microstructural elucidation prepared gels done using shear rheology. Ex vivo drug release studies performed gels.It observed that PEG altered microstructure. viscoelastic in nature suggesting their...

BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective current work was to screen the suitability glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn bioavailability tenofovir disoproxil fumarate (TDF), drug. Spray-drying method used preparation TDF loaded crystal (LCP) consisting GMO/Pluronic lactose monohydrate with an ability situ transform into stable...

Increase in bacterial resistance to most of conventional antibiotics has emerged as one the challenging problems for researcher field biomedical science and engineering. This therefore augers well look possible alternative antimicrobial agents that can overcome this resistance. Nanoparticles metals semiconductors have great potential delivery biology medicine carrying small molecules such drugs, proteins, genes. Metal nanoparticles combined with may show improved efficacy specific treatment,...

Self-emulsifying systems are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions gentle agitation, similar to those would be encountered in the gastrointestinal tract. The process self-emulsification has remained center attraction for most researchers. Controlled hydration self-emulsifying shows formation an intermediate gel phase upon rupture forms emulsion. Current work was undertaken understand explore microstructural...

Poor aqueous solubility of most the phytomolecules has restricted their vital biological use. Cocrystal approach can be one remedies for problem. The present work was carried out with an objective to screen potential electrospray technique towards cocrystallization quercetin (QUE). QUE cocrystallized caffeine (CAF) and nicotinamide (NIC) as coformers. Saturated methanolic solutions either coformers (CAF NIC) in 1:1 ratio were electrosprayed at 40 °C. successfully used CAF NIC separately...

In the present work, novel nanostructures comprising of glyceryl monooleate (GMO) and Eudragit E100 were prepared using high intensity ultrasonic homogenization. 3(2) Factorial design approach was used for optimization nanostructures. Results regression analysis revealed that amount GMO had a drastic effect on particle size percent entrapment efficiency. Optimized carvedilol-loaded (Car-NS) characterized by FTIR, TEM, DSC, in vitro drug release study. Pharmacokinetic parameters such as Cmax,...

Background: The outlook on “Nano-materials, products, medicine and technology” lacks a consensus the definition to be considered by regulatory bodies all over world. Engineered nanoparticles, formulated products containing nanomaterials, are not subject any precise regulation pertaining production, handling labeling till now. Also, nano medicines holding an immense potential involved in treatment diagnosis with emerging research, yet, lag behind unnoticed concerns regarding their safety...