About
Contact & Profiles
A5014472306
Research Areas
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Kinase Regulation and GTPase Signaling
- Phytochemical Studies and Bioactivities
- Receptor Mechanisms and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
University of Bristol
2020-2022
10.1016/j.bcp.2020.113975
article
EN
Biochemical Pharmacology
2020-04-13
10.1016/j.cellsig.2020.109528
article
EN
Cellular Signalling
2020-01-07
10.1182/bloodadvances.2022008466
article
EN
cc-by-nc-nd
Blood Advances
2022-11-07
Abstract The tyrosine kinase BTK plays an important role in platelet function downstream of GPVI and CLEC2 receptors has been proposed as a novel target to prevent thrombosis patients that are at increased risk. However, current clinically approved inhibitors have off effects associated with bleeding In this study, we therefore explored whether can be targeted for degradation human platelets by using recently developed heterobifunctional molecules employ the proteasomal system break down...
10.1101/2022.05.30.493973
preprint
EN
cc-by-nc-nd
bioRxiv (Cold Spring Harbor Laboratory)
2022-05-30
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