Tomás Frazão

ORCID: 0000-0001-5522-4085
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About
Contact & Profiles
Research Areas
  • Plant biochemistry and biosynthesis
  • Plant Gene Expression Analysis
  • Enzyme-mediated dye degradation

Universidade Nova de Lisboa
2023

Abstract C -glycosides are natural products with important biological activities but recalcitrant to degradation. Glycoside 3-oxidases (G3Oxs) recently identified bacterial flavo-oxidases from the glucose-methanol-coline (GMC) superfamily that catalyze oxidation of concomitant reduction O 2 H . This is followed by C-C acid/base-assisted bond cleavage in two-step -deglycosylation pathways. Soil and gut microorganisms have different oxidative enzymes, details their catalytic mechanisms largely...

10.1038/s41467-023-42000-3 article EN cc-by Nature Communications 2023-11-14

Abstract C -glycosides are natural products with important biological activities but recalcitrant to degradation. Glycoside 3-oxidases (G3Oxs) newly identified bacterial flavo-oxidases from the glucose-methanol-coline (GMC) superfamily that catalyze oxidation of concomitant reduction O 2 H . This is followed by C-C acid/base-assisted bond cleavage in two-step -deglycosylation pathways. Soil and gut microorganisms have different oxidative enzymes, details their catalytic mechanisms largely...

10.21203/rs.3.rs-2662172/v1 preprint EN cc-by Research Square (Research Square) 2023-03-10
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