A5066130820- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
- Advanced Sensor and Energy Harvesting Materials
- Wound Healing and Treatments
- Cancer-related Molecular Pathways
- Polymer Surface Interaction Studies
- Supercapacitor Materials and Fabrication
- Animal Diversity and Health Studies
- Burkholderia infections and melioidosis
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Advanced Cellulose Research Studies
- Carbon Nanotubes in Composites
- Cell Image Analysis Techniques
- Additive Manufacturing and 3D Printing Technologies
- Organ Donation and Transplantation
Rochester Institute of Technology
2019-2023
Brigham and Women's Hospital
2023
Harvard University
2023
Pasteur Institute of Iran
2016-2017
Amirkabir University of Technology
2016-2017
Application of wound-healing/dressing biomaterials is amongst the most promising approaches for wound repair through protection from pathogen invasion/contamination, maintaining moisture, absorbing exudates, modulating inflammation, and facilitating healing process. A wide range materials are used to fabricate biomaterials. Active wound-healing/dressings next-generation alternatives passive biomaterials, which provide a physical barrier induce different biological activities, such as...
Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment, which can impact mode and efficacy of cell migration. CAFs are known to increase invasion less-aggressive breast cancer cells through matrix remodeling leader-follower dynamics. Here, we demonstrate that communicate with formation contact-dependent tunneling nanotubes (TNTs), allow for exchange cargo between types. CAF mitochondria an integral component sufficient 3D migration cells. This transfer...
Abstract Parylene has been used widely as a coating on medical devices. It also to fabricate thin films and porous membranes upon which grow cells. Porous are integral components of in vitro tissue barrier co-culture models, their interaction with cells tissues affects the performance physiological relevance these model systems. C N two biocompatible variants potential for use but effect cellular behavior is not well understood more commonly cell culture substrates, such treated polystyrene...
Cellular processes, including differentiation, proliferation, and migration, have been linked to the alignment (anisotropy) orientation (directionality) of collagen fibers in native extracellular matrix (ECM). Given critical role that biophysical cell-matrix interactions play regulating biological functions, several microfluidic-based methods used establish 3D gels with defined fiber properties; these helped quantitative relationships between structural ECM cues observed cell responses....
Combination of electrical stimulation with CNT-based conductive films and obtaining optimum signal parameters for MG-63 cells.
Porous membranes are ubiquitous in cell co-culture and tissue-on-a-chip studies. These materials predominantly chosen for their semi-permeable size exclusion properties to restrict or permit transmigration cell-cell communication. However, previous studies have shown pore size, spacing orientation affect behavior including extracellular matrix production migration. The mechanism behind this is not fully understood. In study, we fabricated micropatterned non-fouling polyethylene glycol (PEG)...
Abstract Porous membranes are fundamental elements for tissue‐chip barrier and co‐culture models. However, the exaggerated thickness of commonly available may represent a stumbling block impeding more accurate in vitro modeling. Existing techniques to fabricate such as solvent cast, spin‐coating, sputtering, plasma‐enhanced chemical vapor deposition (PE‐CVD) result uniform films. Here, robust method generate ultrathin porous parylene C (UPP) is developed not just with precise thicknesses...
The disrupted surface of porous membranes, commonly used in tissue-chip and cellular coculture systems, is known to weaken cell–substrate interactions. Here, we investigated whether surfaces membranes with micron submicron scale pores affect yes-associated protein (YAP) localization differentiation adipose-derived stem cells. We found that these substrates reduce YAP nuclear through decreased cell spreading, consistent reduced interactions, turn enhance adipogenesis while decreasing osteogenesis.
Abstract Bone tissue engineering is a new and applicable emerging approach to repair the bone defects. In this regard, designing robust fabrication of scaffolds that could provide an appropriate environment for cell proliferation differentiation high interest. Electrical conductive which substrate stimulating growth through physiologically relevant physical signaling, electrical stimulation, has shown highly promise in approach. paper, we fabricated carbon nanofiber/gold nanoparticle...
Abstract Porous membranes are fundamental elements for tissue-chip barrier and co-culture models. However, the exaggerated thickness of commonly available impedes an accurate in vitro reproduction biological multi-cellular continuum as it occurs vivo . Existing techniques to fabricate such solvent cast, spin-coating, sputtering PE-CVD result uniform films. To understand critical separation distances various models, a gradient membrane is needed. Here, we developed robust method generate...
ABSTRACT Porous membranes are integral components of in vitro tissue barrier and co-culture models their interaction with cells tissues directly affects the performance credibility these models. Plasma-treated Parylene C N two biocompatible variants perceived potential for use but biocompatibility biological interactions at interface not well understood. Here, we a simple approach benchtop oxygen plasma treatment investigate changes cell spreading extracellular matrix deposition as material...
ABSTRACT The disrupted surface of porous membranes, commonly used in tissue-chip and cellular co-culture systems, is known to weaken cell-substrate interactions. Here, we investigated whether surfaces membranes with micron sub-micron scale pores affect YAP localization differentiation adipose-derived stem cells (ADSCs). We found that these substrates reduce nuclear through decreased cell spreading, consistent reduced interactions, turn enhance adipogenesis, while decreasing osteogenesis....
Tissue engineering as an innovative approach aims to combine engineering, biomaterials and biomedicine eliminate the drawbacks of conventional bone defect treatment. In current study, we fabricated bioengineered electroactive bioactive mineralized carbon nanofibers scaffold for tissue applications. The was using sol-gel method thoroughly characterized by SEM imaging, EDX analysis a 4-point probe. results showed that CNFs have diameter 200 ± 19 nm electrical conductivity 1.02 0.12 S cm-1. in...