A5051367955- Health, Medicine and Society
- Intimate Partner and Family Violence
- Sexual Assault and Victimization Studies
- Inflammatory Myopathies and Dermatomyositis
- Healthcare Systems and Practices
- HIV/AIDS drug development and treatment
- Migration, Health and Trauma
- Criminal Justice and Corrections Analysis
- Child Abuse and Trauma
- Autopsy Techniques and Outcomes
- HIV-related health complications and treatments
- Biochemical and Molecular Research
- Torture, Ethics, and Law
- Mitochondrial Function and Pathology
- Pneumocystis jirovecii pneumonia detection and treatment
- Psychoanalysis and Psychopathology Research
- Medical Malpractice and Liability Issues
- Policing Practices and Perceptions
- Homelessness and Social Issues
- Restraint-Related Deaths
- Workplace Violence and Bullying
- Muscle and Compartmental Disorders
- Historical and Scientific Studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Healthcare Decision-Making and Restraints
Hôpital Jean-Verdier
2012-2024
Université Sorbonne Paris Nord
2013-2024
Inserm
2002-2024
École des hautes études en sciences sociales
2012-2024
Assistance Publique – Hôpitaux de Paris
2012-2024
Institut de Recherche Interdisciplinaire sur les Enjeux Sociaux
2013-2024
Centre National de la Recherche Scientifique
1998-2024
Hôpitaux Universitaires Henri-Mondor
1993-2024
Sorbonne Université
2020-2024
Institut de Recherche en Informatique et Systèmes Aléatoires
2024
1 Statins inhibit synthesis of mevalonate, a precursor ubiquinone that is central compound the mitochondrial respiratory chain. The main adverse effect statins toxic myopathy possibly related to dysfunction. 2 This study was designed evaluate lipid‐lowering drugs on (coenzyme Q10) serum level and function assessed by blood lactate/pyruvate ratio. 3 Eighty hypercholesterolaemic patients (40 treated statins, 20 fibrates, untreated patients, all 80 having total cholesterol levels >6.0 mmol l...
We report on a new maternally-inherited syndrome characterized by combination of sensorineural hearing loss, ataxia and myoclonus in large kindred from Sicily. Hearing loss was the most widespread sometimes only symptom found family members. Sequence analysis mitochondrial DNA regions encompassing tRNA genes revealed presence heteroplasmic insertion at nucleotide position 7472. The adds seventh cytosine to six-cytosine run that is part Ser(UCN) gene. Conformational showed this mutation...
Abstract Context.—Autopsy rates have been declining throughout the world, although preservation of autopsy is considered a fundamental principle medical care. In France, 1994 bioethics law requires physicians to inform relatives before performing an autopsy. Objective.—To analyze following factors that potentially influence hospital rates: legal constraints, reporting times, opinions requesting autopsies and pathologists regarding usefulness in patient care, use material research...
○ Context.-Autopsy rates have been declining throughout the world, although preservation of autopsy is considered a fundamental principle medical care. In France, 1994 bioethics law requires physicians to inform relatives before performing an autopsy. Objective.-To analyze following factors that potentially influence hospital rates: legal constraints, reporting times, opinions requesting autopsies and pathologists regarding usefulness in patient care, use material research publications....
Study questions To describe the prevalence of physical, sexual, and psychological intimate partner violence (IPV) against women in European Union (EU) to search for their determinants among demographic, socioeconomic, health-related factors, characteristics. Methods Observational study. Data from survey, first study conducted EU, which simultaneously measured all dimensions IPV many The EU Agency Fundamental Rights randomly face-to-face interviews 28 countries with 42,002 aged 18–74 who...
To compare the consequences of sexual assault based on relationship woman to her named assailant.From January 2008 March 2011, we conducted an observational and prospective study females older than age 15 years who were examined at a referral center. Data collected comparisons made between groups victim's assailant: current or former intimate partner (grouped as partner), stranger, acquaintance. regarding patients, assailants, type assault. At 1-month follow-up examination, evaluated...
Abstract Objective . To evaluate the use of lactate: pyruvate ratio as a test for detection zidovudine myopathy. Methods Twenty consecutive human immunodeficiency virus–infected patients with muscle involvement and 20 without were studied prospectively. Blood lactate levels serum creatine kinase tested, was assessed both clinically electrophysiologically, biopsy performed in Results Nine had biopsy‐proven All 9 high lactate:pyruvate ratio, elevations on 2 determinations 6 1 3 patients. Two...
Abstract Zidovudine can induce a mitochondrial myopathy with ragged‐red fibers and partial cytochrome c oxidase deficency. In an attempt to improve histological assessment of zidovudine myopathy, we evaluated cytochorme histochemical reaction in the muscle 10 patients biopsy‐proven (Group 1), myopathic immunodeficiency virus (HIV)‐infected not treated by who had immunohistological profile HIV‐associated or other neuromuscular disorders 3). Among receivers, deficiency was found from Group 1 7...
Crystallographic analysis indicated that Clostridium thermocellum endoglucanase CelD contained three Ca2+-binding sites, termed A, B, and C, one Zn2+-binding site. The protein contributed five, six, of the coordinating oxygen atoms present at sites respectively. Proteins altered by mutation in site A (CelDD246A), B (CelDD261A), or C (CelDD523A) were compared with wild type CelD. isotherm was compatible two high affinity (Ka= 2 × 106M−1) low (Ka< 105M−1). isotherms mutated proteins showed...