A5102840314- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Hedgehog Signaling Pathway Studies
- PI3K/AKT/mTOR signaling in cancer
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- Digestive system and related health
- Cytokine Signaling Pathways and Interactions
- Fibroblast Growth Factor Research
- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- Effects of Radiation Exposure
- Glycosylation and Glycoproteins Research
Spanish National Cancer Research Centre
2014-2019
University of Basel
2007-2014
Friedrich Miescher Institute
2014
Abstract An epithelial–mesenchymal transition (EMT) underlies malignant tumor progression and metastatic spread by enabling cancer cells to depart from the primary tumor, invade surrounding tissue, disseminate distant organs. EMT also enriches for stem (CSC) increases capacity of initiate propagate tumors upon transplantation into immune-deficient mice, a major hallmark CSCs. However, molecular mechanisms promoting tumorigenicity undergoing an CSCs have remained widely elusive. We here...
Ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a lethal disorder, by means of unknown mechanisms. We show that high-dose irradiation increases unconventional prefoldin RPB5 interactor (URI) levels in mouse intestinal crypt, but organ regeneration correlates with URI reductions. overexpression intestine protects mice from radiation-induced GIS, whereas halving expression sensitizes to IR. specifically inhibits β-catenin stem cell-like label-retaining (LR) cells, which are...