A5032910154- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Microbial Natural Products and Biosynthesis
- Metal complexes synthesis and properties
- Corrosion Behavior and Inhibition
- Multicomponent Synthesis of Heterocycles
- Marine Sponges and Natural Products
- Synthesis of Indole Derivatives
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Photochromic and Fluorescence Chemistry
- Nanomaterials for catalytic reactions
- Quinazolinone synthesis and applications
- Microbial Metabolism and Applications
- Mast cells and histamine
- Antimicrobial agents and applications
- Organometallic Compounds Synthesis and Characterization
- Synthesis of Organic Compounds
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Pyrroles
- Extraction and Separation Processes
- Synthesis and Biological Activity
- Electrochemical Analysis and Applications
Al-Azhar University
2014-2024
Institut de Chimie de Strasbourg
2024
Centre National de la Recherche Scientifique
2024
Université de Strasbourg
2024
Bielefeld University
2017-2021
In this research paper, aromatic sulfonamide-derived ethyl ester (p-TSAE) and its acyl hydrazide (p-TSAH) were directly synthesized, characterized, employed for the first time as prospective anticorrosive agents to protect mild steel in 1.0 M HCl conditions. The corrosion efficiency was probed by electrochemical methods including polarization, impedance, frequency modulation measurements. Optimal efficiencies of 94% 92% detected ester, respectively, revealing excellent inhibition. Moreover,...
Herein, the chemical synthesis of new thiazole-based benzenesulfonamide-linked morpholine 4a,b–7 via late-stage thiazolation corresponding thiosemicarbazone 3 is reported.
Novel thiazole hybrids were synthesized via thiazolation of 4-phenylthiosemicarbazone (
Abstract In the search for new bioactive compounds from extremophilic actinomycetes, a marine actinomycete strain, Nocardiopsis lucentensis sp. ASMR2 has been isolated and taxonomically identified plants collected in Red Sea at Hurghada coasts. A large-scale fermentation of strain on modified rice solid medium was performed, followed by work-up purification obtained extract using series chromatographic purifications, delivering novel butenolide system 3′-hydroxy- N...
Abstract A new series of heterocyclic Schiff bases 2–9 containing indole moiety were synthesized by facile and efficient condensation indole-3/2/5-carboxaldehyde ( 1a / 1b 1c ) with different aromatic primary amines using conventional and/or microwave irradiation methods. The structures the obtained compounds assigned sophisticated spectroscopic spectrometric techniques (1D-NMR, 2D-NMR MS). screened for their cytotoxicity antibacterial activities. In vitro screening revealed that compound 5...
A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous (4a-f 8a-e) was described. Further, formyl (5a,d-f) nitro (9a,d-f) derivatives were synthesized via C-N coupling reaction of various cyclic secondary amines 4-chloro-3-(formyl-/nitro)coumarins (1a,c), respectively. The confirmed compounds screened for their in vitro anti-proliferative activity against KB-3-1, A549 PC3 human cancer cell lines using resazurin...
Abstract In this research article, the chemical synthesis of new N ‐phenylpyrazolone‐ ‐benzylthiazole hybrids ( 3–6 ) via late‐stage thiazolation corresponding benzylthiosemicarbazone 2 was reported. The skeletal structural molecules were validated by instrumental measurements (FT‐IR, NMR, and EI‐MS). vitro cytotoxicity‐based cellular MTT bioassay shows that compound 3 bears an ‐benzyl‐4‐thiazolone moiety is most potent one toward osteosarcoma cell line (Hos) with IC 50 value 5.8 ± 0.1 μM,...
Herein, synthesis of new designated azines-based naphthalene scaffold (3a–10) was assisted by CuCl2.2H2O for the first time. Their biological screening manifested that azines 3a, 4, 7, 9, and 10 exhibit effectual mushroom tyrosinase inhibition with IC50 values within ambit 3.75–12.36 µM. Mostly, 4 9 demonstrated about four-fold enhancement in activity (IC50 = 3.91 ± 0.16, 3.75 0.15 µM, respectively) comparable to kojic acid 16.86 0.84 µM). Molecular docking against (2Y9X) proved significant...
Abstract In our persistent research for new bioactive secondary metabolites from marine actinomycetes, Nocardiopsis sp. AS23C strain was isolated the Alga Sargassum arnaudianum collected in Red Sea at Hurghada coast, Egypt. A large‐scale fermentation of on M 2 medium containing 50% sea water, followed by fractionation and purification obtained extract afforded a phenolic acid derivative, 4‐amino‐6‐methylsalicylic ( 1a ), together with 5‐methylresorcinol ) linoleic 3 ). Their molecular...
We report on the synthesis of new coumarin derivatives coupled with heterocyclic and bifunctionalized moieties at position 7. The proposed structures were confirmed by correct elemental analysis spectral data (IR, MS, 1 H NMR 13 C NMR). Some selected also screened for their antioxidant anticancer activities. results indicated that 7-{[6-(4-nitrophenyl)-7 -[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl]methoxy}-4-phenyl- -chromen-2-one has highest activity in tested compounds.
Abstract Germs are transmitted in different ways and remain viable or infectious on metal, glass, wood, fabrics, plastic surfaces for prolonged periods of time. Thus, sterilizing commonly handled everyday objects public places with high contamination potential is a major global strategy to combat the spread pathogenic microorganisms. Consequently, our response development durable surface‐active coating embedded new Gd(I)/Cs(III) complexes that derived from condensation thiocarbohydrazide...
Abstract Three new series of bis-indole derivatives were synthesized based on p -phenylenediamine ( 2–4, 5 and 6 ) 4,4′-ethylenedianiline moieties 7–9 using facile efficient condensation three positional isomeric indole-carboxaldehyde 1a–c with bifunctional amines upon microwave irradiation. The symmetric dimeric indole 2–4 as well non-symmetric analogues obtained by in situ the respective 3-, 2- 5-isomeric indole-carboxaldehydes -phenylenediamine, while compounds resulted from...
Purpose This paper aims to focus on the synthesis of macrocyclic complexes (Cu and Zn) their applications as anticorrosive materials in epoxy paint formulation for surface coating application. Design/methodology/approach A selected Cu(II) Zn(II) were prepared via template characterized using Fourier transform infrared, thermal gravimetric analysis, scanning electron microscope, flexibility, hardness adhesion films paint. Findings The corrosion resistance epoxy-painted was improved due...
Hydrazone‒carbodithioate ligands and their transition-metal complexes are interesting compounds with wide applications. In this study, we synthesized a new hydrazone‒carbodithioate ligand via the acetic acid-promoted condensation of S-benzyldithiocarbazate 4-acetylbenzenesulfonamide. Its Cu(II) Zn(II) were prepared, structural features chelation modes clarified using various spectroscopic analytical techniques, including elemental analysis, molar conductivity, IR, EI-MS, 1H NMR, 13C-NMR, EDX...