A5076065411- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Characterization and Applications of Magnetic Nanoparticles
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Porphyrin and Phthalocyanine Chemistry
- Gas Sensing Nanomaterials and Sensors
- Electrospun Nanofibers in Biomedical Applications
- Carbon and Quantum Dots Applications
- Microfluidic and Bio-sensing Technologies
- Erythrocyte Function and Pathophysiology
- Silicon Carbide Semiconductor Technologies
- Luminescence Properties of Advanced Materials
- Histone Deacetylase Inhibitors Research
George Washington University
2020-2024
Arsenal Biosciences (United States)
2024
Stanford University
2021-2022
Italian Institute of Technology
2015-2021
University of Genoa
2017-2019
Istituto Nazionale di Fisica Nucleare, Sezione di Genova
2015
ConspectusCombining hard matter, like inorganic nanocrystals, and soft materials, polymers, can generate multipurpose materials with a broader range of applications respect to the individual building blocks. Given their unique properties at nanoscale, magnetic nanoparticles (MNPs) have drawn great deal interest due potential use in biomedical field, targeting several such as heat hubs hyperthermia (MHT, heat-damage based therapy), contrast agents resonance imaging (MRI), nanocarriers for...
The use of magnetic nanoparticles in oncothermia has been investigated for decades, but an effective combination and localized chemotherapy under clinical hyperthermia (MH) conditions calls novel platforms. In this study, we have engineered thermoresponsive iron oxide nanocubes (TR-cubes) to merge MH treatment with heat-mediated drug delivery, having mind the translation nanoplatform. We chosen based a cubic shape because their outstanding heat performance conditions, which makes them...
Abstract Nanoparticle‐based magnetic hyperthermia is a well‐known thermal therapy platform studied to treat solid tumors, but its use for monotherapy limited due incomplete tumor eradication at temperature (45 °C). It often combined with chemotherapy obtaining more effective therapeutic outcome. Cubic‐shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as agents and cytotoxic agent the known ion toxicity, allowing achievement of both heat effects from single platform. In addition this...
Cancer stem cells (CSCs) are the tumor cell subpopulation responsible for resistance to chemotherapy, recurrence, and metastasis. An efficient therapy must act on low proliferating quiescent-CSCs (q-CSCs). We here investigate effect of magnetic hyperthermia (MHT) in combination with local chemotherapy as a dual inhibit patient-derived colorectal qCR-CSCs. apply iron oxide nanocubes MHT heat mediators, coated thermoresponsive polymer (TR-Cubes) loaded DOXO (TR-DOXO) chemotherapeutic agent....
We report a novel approach based on non-covalent interactions for the functionalization of carbon nano-onions (CNOs) with fluorophores.
In this work, a novel drug delivery system consisting of poly(ε-caprolactone) (PCL) electrospun fibers containing an ad-hoc-synthesized star polymer made up poly(amido-amine) (PAMAM) core and PCL branches (PAMAM-PCL) was developed. The latter which synthesized via the ring opening polymerization ε-caprolactone, starting from hydroxyl-terminated PAMAM dendrimer characterized by means 1H NMR, IR DSC, found to be compatible with both matrix hydrophilic chemotherapeutic drug, doxorubicin (DOXO),...
Longitudinal multimodal imaging presents unique opportunities for noninvasive surveillance and prediction of treatment response to cancer immunotherapy. In this work we first designed a novel granzyme B activated self-assembly small molecule, G-SNAT, the assessment cytotoxic T lymphocyte mediated cell killing. G-SNAT was found specifically detect activity within granules cells engaged in vitro. lymphoma tumor-bearing mice, retention cyanine 5 labeled G-SNAT-Cy5 correlated CAR exocytosis...
In this study, we describe poly (lactic-co-glycolic) acid (PLGA)-based nanoparticles that combine photothermal therapy (PTT) with epigenetic for melanoma. Specifically, co-encapsulated indocyanine green (ICG), a PTT agent, and Nexturastat A (NextA), an drug within PLGA (ICG-NextA-PLGA; INAPs). We hypothesized combining elicits favorable cytotoxic immunomodulatory responses result in improved survival melanoma-bearing mice. utilized nanoemulsion synthesis scheme to co-encapsulate ICG NextA...
Photothermal therapy (PTT) represents a promising modality for tumor control typically using infrared light-responsive nanoparticles illuminated by wavelength-matched external laser. However, due to the constraints of light penetration, PTT is generally restricted superficially accessible tumors. With goal extending benefits all settings, interstitial (I-PTT) evaluated photothermal activation intratumorally administered Prussian blue with laser fiber positioned interstitially within tumor....
The synovial sarcoma X breakpoint 2 (SSX2) belongs to a multigene family of cancer-testis antigens and can be found overexpressed in multiple malignancies. Its restricted expression immune-privileged normal tissues suggest that SSX2 may relevant target antigen for chimeric receptor (CAR) therapy. We have developed T cell (TCR)-like antibody (Fab/3) binds peptide 41-49 (KASEKIFYV) the context HLA-A∗-0201. sequence Fab/3 was utilized engineer CAR with CD3 zeta intra-cellular domain along...
Prussian blue nanoparticles (PBNPs) are effective photothermal therapy (PTT) agents: they absorb near-infrared radiation and reemit it as heat via phonon-phonon relaxations that, in the presence of tumors, can induce thermal immunogenic cell death. However, context central nervous system (CNS) off-target effects PTT have potential to result injury healthy CNS tissue. Motivated by this need for targeted agents we present a PBNP formulation that targets fibroblast growth factor-inducible 14...
We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes photoluminescent upconverting (UCNPs). The controlled simultaneous incorporation both types (NPs) was obtained by controlling solvent composition addition rate destabilizing solvent. magnetic properties MNPs remained unaltered after their encapsulation into polymeric beads as shown T2 relaxivity measurements. UCNPs maintain even when embedded with...
Aim: We investigate combining Prussian Blue nanoparticles (PBNPs), as photothermal therapy (PTT) agents, with agonistic CD137 antibodies (αCD137) on a single nanoparticle platform to deliver non-toxic, anti-tumor efficacy in SM1 murine melanoma.
Abstract In solid tumors, CAR T cell efficacy is limited by on-target off-tumor toxicity, as well functional suppression the tumor microenvironment (TME). AB-1015 an integrated circuit (ICT cell) developed for use in ovarian cancer. The transgene cassette includes two modules: A) a sequential ”AND” logic gate designed to limit toxicity through dual antigen recognition, which consists of priming receptor (PrimeR) against ALPG/P and inducible Mesothelin(MSLN)-targeted chimeric (CAR) that...
Aim: To investigate Prussian blue nanoparticles (PBNPs) coated with the synthetic analog of dsRNA polyinosinic-polycytidylic acid (polyIC) for their ability to function as HIV latency reversing agents. Methods: A layer-by-layer method was used synthesize polyIC-coated PBNPs (polyIC-PBNPs). PolyIC-PBNPs were stable and monodisperse, maintained native absorbance properties both polyIC obtained high nanoparticle collection yield attachment efficiencies. Results: more effective in reactivating...
Current antiretroviral therapies (ART) for human immunodeficiency virus (HIV) are not curative, as the persists in latent reservoirs, requiring lifelong adherence to ART and increasing risk of co-morbidities. "Shock kill" approaches reactivate HIV from reservoirs followed by administration anti-HIV drugs represent a promising strategy eradicating HIV. To achieve effective shock kill, we describe eradicate reservoir that combines latency reversing agents (LRAs), broadly neutralizing...
Abstract Longitudinal multimodal imaging presents unique opportunities for noninvasive surveillance and prediction of treatment response to cancer immunotherapy. In this work we first designed a novel granzyme B activated self-assembly small molecule, G-SNAT, quantitative assessment cytotoxic T lymphocyte mediated cell killing in vivo . lymphoma tumor bearing mice, the retention cyanine 5 labeled G-SNAT-Cy5 was shown be highly correlated CAR T-cell release eradication. colorectal...