A5051374794- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Insect and Pesticide Research
- Virology and Viral Diseases
- Insect and Arachnid Ecology and Behavior
- Cocoa and Sweet Potato Agronomy
- Viral Infections and Vectors
- Insect-Plant Interactions and Control
- Parasitic Diseases Research and Treatment
- Entomopathogenic Microorganisms in Pest Control
MRC University of Glasgow Centre for Virus Research
2019-2024
The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. release aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses is being trialled several countries. However, these efforts are compromised many endemic regions due co-localization secondary vector albopictus, Asian tiger mosquito. Ae. albopictus expanding distribution...
In the past decades, dengue incidence has dramatically increased all over world. An emerging control strategy utilizes Aedes aegypti mosquitoes artificially transinfected with bacterial symbiont Wolbachia , ultimate aim of replacing wild mosquito populations.
Abstract Dengue represents an increasing public health burden worldwide. In Africa, underreporting and misdiagnosis often mask its true epidemiology, dengue is likely to be both more widespread than reported data suggest in incidence distribution. Wolbachia ‐based control underway Asia the Americas but has not date been deployed Africa. Due genetic heterogeneity of African Aedes aegypti populations complexity host‐symbiont interactions, characterization key parameters ‐carrying mosquitoes...
Wolbachia are widespread maternally-transmitted bacteria of arthropods that often spread by manipulating their host's reproduction through cytoplasmic incompatibility (CI). Their invasive potential is currently being harnessed in field trials aiming to control mosquito-borne diseases. genomes commonly harbour prophage regions encoding the cif genes which confer ability induce CI. Recently, a plasmid-like element was discovered wPip, strain infecting Culex mosquitoes; however, it unclear how...
Abstract Symbiotic and pathogenic microorganisms such as bacteria fungi represent promising alternatives to chemical insecticides respond the rapid increase of insecticide resistance vector‐borne disease outbreaks. This study investigated interaction two strains Wolbachia , w AlbB Au, with natural entomopathogenic from Burkina Faso Metarhizium pingshaense known be lethal against Anopheles mosquitoes. In addition showing potential African Aedes aegypti wild‐type populations, our shows that Au...
The primary route of Zika virus (ZIKV) transmission is through the bite an infected
Abstract Environmental factors play a crucial role in the population dynamics of arthropod endosymbionts, and therefore deployment Wolbachia symbionts for control dengue arboviruses. The potential to invade, persist block virus transmission depends part on its intracellular density. Several recent studies have highlighted importance larval rearing temperature modulating densities adults, suggesting that elevated temperatures can severely impact some strains, while having little effect...
The intracellular bacterium
Abstract Wolbachia are widespread maternally-transmitted bacteria of arthropods that often spread by manipulating their host’s reproduction through cytoplasmic incompatibility (CI). Their invasive potential is currently being harnessed in field trials aiming to control mosquito-borne diseases. genomes commonly harbour prophage regions encoding the cif genes which confer ability induce CI. Recently, a plasmid-like element was discovered w Pip, strain infecting Culex mosquitoes; however, it...
Wolbachia symbionts introduced into Aedes mosquitoes provide a highly effective dengue virus transmission control strategy, increasingly utilised in many countries an attempt to reduce disease burden. Whilst against and other positive-sense RNA viruses, it remains unclear how is negative-sense viruses. Therefore, the effect of on Bunyamwera (BUNV) infection aegypti was investigated using wMel wAlbB, two strains currently used releases for control, as well wAu, strain that typically persists...
Abstract The intracellular bacterium Wolbachia inhibits virus replication and is being harnessed around the world to fight mosquito-borne diseases through releases of mosquitoes carrying symbiont. strains vary in their ability invade mosquito populations suppress viruses part due differences density within insect associated fitness costs. Using whole-genome sequencing, we demonstrate existence two variants w AlbB, a strain released natural Aedes aegypti mosquitoes. display striking genome...
Abstract The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. release aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses is being trialled several countries. However, these efforts are compromised many endemic regions due co-localization secondary vector albopictus , Asian tiger mosquito. Ae. expanding distribution...
Abstract The primary route of Zika virus (ZIKV) transmission is through the bite an infected Aedes mosquito, when it probes skin a vertebrate host during blood meal. Viral particles are injected into site together with mosquito saliva and complex mixture other components. Some them shown to play key role in augmentation arbovirus infection host, increased viremia and/or morbidity. This vector-derived contribution not usually considered vaccine candidates tested preclinical animal models. In...