A5048970708- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Pharmacology and Obesity Treatment
- Memory and Neural Mechanisms
- Opioid Use Disorder Treatment
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Substance Abuse Treatment and Outcomes
- Medical Imaging Techniques and Applications
- Neurology and Historical Studies
- Receptor Mechanisms and Signaling
- Eating Disorders and Behaviors
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Pain Mechanisms and Treatments
- Sexuality, Behavior, and Technology
- Obsessive-Compulsive Spectrum Disorders
- Nutrition, Genetics, and Disease
- Mental Health Research Topics
- Cannabis and Cannabinoid Research
Icahn School of Medicine at Mount Sinai
2016-2025
Western University of Health Sciences
2024-2025
Texas Tech University
2024-2025
Texas Tech University Health Sciences Center
2024-2025
Desert Institute For Spine Care
2025
NeuroGenetic Pharmaceuticals (United States)
2024-2025
Ariel University
2025
Mount Sinai Hospital
2018-2024
Case Western Reserve University
2023-2024
MetroHealth
2017-2024
Two different attentional networks have been associated with visuospatial attention and conflict resolution. In most situations either one of the two is active or both are increased in activity together. By using functional magnetic resonance imaging a flanker task, we show conditions which network (anterior system) whereas other (visuospatial reduced, showing that selection separate aspects attention. Further, distinguish between neural systems involved forms conflict. Specifically,...
Recently there has been debate concerning the role of brain dopamine in reward and addiction. David Nutt associates eloquently proposed that (DA) may be central to psycho stimulant dependence some what important for alcohol, but not opiates, nicotine or even cannabis. Others have also argued surfeit theories can explain example cocaine seeking behavior as well non-substance-related addictive behaviors. It seems prudent distinguish between constitutes "surfeit" compared to" deficit" terms...
Dopaminergic reward dysfunction in addictive behaviors is well supported the literature. There evidence that alterations synchronous neural activity between brain regions subserving and various cognitive functions may significantly contribute to substance-related disorders. This study presents first showing a pro-dopaminergic nutraceutical (KB220Z) enhances, above placebo, functional connectivity areas rat. These include nucleus accumbens, anterior cingulate gyrus, thalamic nuclei,...
Changes in the nomenclature of addictions suggest a significant shift conceptualization addictions, where non-substance related behaviors can also be classified as addictions. A large amount data provides empirical evidence that there are overlaps different types addictive etiology, phenomenology, and underlying psychological biological mechanisms. Our aim was to investigate co-occurrences wide range substance use behavioral The present epidemiological analysis carried out part Psychological...
It is unclear whether attention deficit hyperactive disorder (ADHD) a hypodopaminergic or hyperdopaminergic condition. Different sets of data suggest either hypoactive dopamine system. Since indirect methods used in earlier studies have arrived at contradictory conclusions, we directly measured the tonic and phasic release ADHD volunteers. The healthy control volunteers was compared using dynamic molecular imaging technique. during performance Eriksen's flanker task two groups single scan In...
Background: Buprenorphine and naloxone (bup/nal), a combination partial mu receptor agonist low-dose delta antagonist, is presently recommended used to treat opioid-use disorder. However, literature review revealed paucity of research involving data from urine drug tests that looked at compliance abstinence in one sample. Method: Statistical analysis the Comprehensive Analysis Reported Drugs (CARD) was assess during treatment large cohort bup/nal patients attending chemical-dependency...
There is need for better treatments of addictive behaviors, both substance and non-substance related, termed Reward Deficiency Syndrome (RDS). While the FDA has approved pharmaceuticals under umbrella term Medication Assisted Treatment (MAT), these drugs are not optimal.It our contention that work well in short-term by blocking dopamine function leading to psychological extinction. However, use buprenorphine/Naloxone over a long period time results unwanted addiction liability, reduced...
OPINION article Front. Psychiatry, 27 November 2018Sec. Addictive Disorders Volume 9 - 2018 | https://doi.org/10.3389/fpsyt.2018.00548
Unlike other drugs of abuse such as alcohol, nicotine, opiates/opioids, the FDA has not approved any agent to treat psychostimulant dependence. Certainly, it is widely acceptable that dopaminergic signaling a key factor in both initiation and continued motivation this class stimulant substances. It also well accepted psychostimulants cocaine affect only release neuronal dopamine at nucleus accumbens (NAc), but powerful inhibitory actions on transporter system. Understandably, certain...
Addiction is a public health crisis in the United States. Understanding cause and providing effective treatment for patients-in particular, those with substance use disorders-is challenging. Research has demonstrated that addiction not flaw one's moral fiber or disease of choice; rather, it driven by alterations neuronal mechanisms, especially involve neurotransmitter dopamine, which plays critical role brain's reward pathway. Much osteopathic philosophy based on concept total body...
Reward Deficiency Syndrome (RDS) encompasses many mental health disorders, including a wide range of addictions and compulsive impulsive behaviors. Described as an octopus behavioral dysfunction, RDS refers to abnormal behavior caused by breakdown the cascade reward in neurotransmission due genetic epigenetic influences. The resultant deficiencies interfere with pleasure derived from satisfying powerful human physiological drives. Epigenetic repair may be possible precision gene-guided...
This multi-center study of dual diagnosis (DD) programs involved 804 residential patients with co-occurring alcohol and mental health disorders.The Addiction Severity Index was administered at admission one, six, 12 months after discharge.Repeated measures analysis showed the intoxication rate per month stabilized between six 68% still in remission an 88% mean reduction from baseline (F = 519, p < .005).A comparison without weekly relapse produced significant differences hospitalization...
This case series presents the novel Genetic Addiction Risk Score (GARS®) coupled with a customized pro-dopamine regulator matched to polymorphic reward genes having hypodopaminergic risk.The proband is female history of drug abuse and alcoholism. She experienced car accident under influence voluntarily entered treatment. Following an assessment, she was genotyped using GARS, started neuronutrient KB220 base indicated by identified polymorphisms. began taking it in April 2018 continues.She...