A5068241160- Genomics and Phylogenetic Studies
- Oral microbiology and periodontitis research
- Insect symbiosis and bacterial influences
- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Salivary Gland Disorders and Functions
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Probiotics and Fermented Foods
- Folate and B Vitamins Research
- Evolution and Genetic Dynamics
- Biofuel production and bioconversion
- Liver Disease Diagnosis and Treatment
- Aquatic Ecosystems and Phytoplankton Dynamics
- Oral Health Pathology and Treatment
- Porphyrin Metabolism and Disorders
- Hepatitis B Virus Studies
- Plant and Fungal Interactions Research
- Catalysis for Biomass Conversion
- Legionella and Acanthamoeba research
- Aquatic Ecosystems and Biodiversity
- Iron Metabolism and Disorders
- Mycobacterium research and diagnosis
- Hepatitis C virus research
Oak Ridge National Laboratory
2015-2022
Vanderbilt University
2020-2022
Vanderbilt Health
2021
University of Tennessee at Knoxville
2018-2019
North Carolina State University
2014-2015
Akkermansia muciniphila is a mucin-degrading bacterium found in the gut of most humans and considered "next-generation probiotic." However, knowledge genomic physiological diversity human-associated sp. strains limited. Here, we reconstructed 35 metagenome-assembled genomes combined them with 40 publicly available for comparative analysis. We identified at least four species-level phylogroups (AmI to AmIV), distinct functional potentials. Most notably, genes cobalamin (vitamin B12)...
ABSTRACT The human oral microbiota encompasses representatives of many bacterial lineages that have not yet been cultured. Here we describe the isolation and characterization previously uncultured Desulfobulbus oralis , first human-associated representative its genus. As mammalian-associated microbes rarely free-living close relatives, D. provides opportunities to study how bacteria adapt evolve within a host. This sulfate-reducing deltaproteobacterium has adapted subgingival niche by...
Microbial symbiosis and speciation profoundly shape the composition of life’s biodiversity. Despite enormous contributions these two fields to foundations modern biology, there is a vast exciting frontier ahead for research, literature, conferences address neglected prospects merging their study. Here, we survey synthesize exemplar cases how endosymbionts microbial communities affect animal hybridization vice versa. We conclude that though number case studies remain nascent, wide-ranging...
We consider an in-host model for HIV-1 infection dynamics developed and validated with patient data in earlier work [7]. revisit the light of progress over last several years understanding progression humans. then statistical models to describe use these residual plots generalized least squares problems develop accurate descriptions proper weights data. recent parameter subset selection techniques [5,6] investigate impact estimated parameters on corresponding scores. Bootstrapping asymptotic...
Compounds such as furfural and 5-hydroxymethylfurfural (5-HMF) are generated through the dehydration of xylose glucose, respectively, during dilute-acid pretreatment lignocellulosic biomass also potent microbial growth fermentation inhibitors. The enzymatic reduction these furan aldehydes to their corresponding, less toxic, alcohols is an engineering approach that has been successfully implemented in both Saccharomyces cerevisiae ethanologenic Escherichia coli, but not yet investigated...
Phylosymbiosis is a cross-system trend whereby microbial community relationships recapitulate the host phylogeny. In Nasonia parasitoid wasps, phylosymbiosis occurs throughout development, distinguishable between sexes, and benefits development survival. Moreover, microbiome shifts in hybrids as rare Proteus bacterium becomes dominant. The larval then catastrophically succumb to bacterium-assisted lethality reproductive isolation species. Two important questions for understanding are (i) do...
We consider a model for in-host HIV-1 infection dynamics developed and validated with patient data in earlier work [1]. revisit the light of progress over last several years understanding progression humans. then statistical models to describe use these residual plots weighted least squares problems develop accurate descriptions proper weights data. Bootstrapping is used confidence intervals resulting parameter estimates establish absence correlation estimated parameters.
Actinomyces sp. HMT897 strain ORNL0104 was isolated from a human saliva sample and can serve as host for the ectobiont Saccharibacteria (TM7) HMT351. Its 3.3-Mb chromosome completely sequenced using PacBio long reads, it encodes 2,407 proteins 63 RNAs.
ABSTRACT Background Akkermansia muciniphila is a mucin-degrading bacterium found in the gut of most healthy humans and considered ‘next-generation probiotic.’ However, knowledge genomic physiological diversity human associated limited, as only one species has been formally described. Results To begin to fill this gap, we reconstructed 35 high-quality metagenome assembled genomes from children combined them with 40 other publicly available adults mice for comparative analysis. We identified...
"Cand. Nanosynbacter sp. HMT352" strain KC1 is an ectoparasitic saccharibacterium/TM7 that was co-isolated from a human saliva sample with its obligate bacterial host, Schaalia odontolytica. The genome of enables studies the mechanisms and evolution interspecies interactions and, for oral species, their potential roles in health disease.
ABSTRACT Phylosymbiosis is a cross-system trend whereby microbial community relationships recapitulate the host phylogeny. In Nasonia parasitoid wasps, phylosymbiosis occurs throughout development, distinguishable between sexes, and benefits development survival. Moreover, microbiome shifts in hybrids as rare Proteus bacteria becomes dominant. The larval then catastrophically succumb to bacterial-assisted lethality reproductive isolation species. Two important questions for understanding...