A5091406032- Membrane Separation Technologies
- Catalysis for Biomass Conversion
- Biofuel production and bioconversion
- Protein purification and stability
- Membrane-based Ion Separation Techniques
- Membrane Separation and Gas Transport
- Electrohydrodynamics and Fluid Dynamics
- Microbial Metabolic Engineering and Bioproduction
- Microfluidic and Capillary Electrophoresis Applications
- Enzyme Catalysis and Immobilization
- Lignin and Wood Chemistry
- Microfluidic and Bio-sensing Technologies
- Advanced Cellulose Research Studies
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Electrostatics and Colloid Interactions
- Electrospun Nanofibers in Biomedical Applications
- Surface Modification and Superhydrophobicity
- Advanced Polymer Synthesis and Characterization
- Surface and Thin Film Phenomena
- Advanced oxidation water treatment
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Extraction and Separation Processes
University of Arkansas at Fayetteville
2016-2025
Asahi Kasei (United States)
2020
Smith College
2017
Syracuse University
2017
University of Memphis
2017
Texas A&M University
2017
Louisiana State University Health Sciences Center New Orleans
2017
John Wiley & Sons (United States)
2017
Colorado State University
2002-2012
University of Duisburg-Essen
2012
Classical molecular dynamics simulations were performed to investigate the effects of salt on lower critical solution temperature (LCST) Poly (N-isopropylacrylamide) (PNIPAM). PNIPAM is often studied as a protein proxy due presence peptide bond in its monomer unit. sensitive polymer which exhibits hydrophobic−hydrophilic phase transition at LCST. The will shift LCST, typically temperature. This LCST follows so-called Hofmeister series. Molecular (MD) 1 M NaCl, NaBr, NaI, and KCl carried out...
Dehydration of neutral and protonated glycerol was investigated using quantum mechanical calculations (CBS-QB3). Calculations on show that there is a high barrier for simple 1,2-dehydration, Ea = 70.9 kcal mol-1, which lowered to 65.2 mol-1 pericyclic 1,3-dehydration. In contrast, the barriers dehydration are much lower. mechanisms involving hydride transfer, pinacol rearrangement, or substitution reactions have between 20 25 mol-1. Loss water from via results in either oxirane oxetane...
Under relatively mild conditions (≤140 °C, 1 atm) and in the absence of added acid catalysts typically employed biomass conversion, cellulose dissolved certain ionic liquids (ILs) has been converted into water-soluble reducing sugars high total sugar yield (up to 97%), or directly platform chemical 5-hydroxymethyl furfural (HMF) conversion 89%) when CrCl2 is added. The combined study experimental methods ab initio calculations demonstrates that significantly increased Kw by ILs IL−water...
Virus filtration is used to ensure the high level of virus clearance required in manufacture biopharmaceutical products such as monoclonal antibodies. Flux decline during can occur due formation reversible aggregates consisting self-assembled monomeric antibody molecules, particularly at concentrations. While size exclusion chromatography generally unable detect these aggregates, dynamic light scattering may be determine their presence. minimized by pretreating feed using a membrane adsorber...
The decomposition of xylose has been studied using quantum mechanical calculations supported by NMR data. Proposed mechanisms for the have investigated obtaining structures and energies transition states products. intent this study was to understand experimentally observed formation furfural formic acid that occurs during in mildly hot acidic solutions. A mechanism involving opening pyranose ring subsequent dehydration aldose compared a direct intramolecular rearrangement protonated...
Presented here is a radically novel approach to reduce concentration polarization and, potentially, also fouling by colloids present in aqueous feeds: magnetically responsive micromixing membranes. Hydrophilic polymer chains, poly(2-hydroxyethyl methacrylate) (PHEMA), were grafted via controlled surface-initiated atom transfer radical polymerization (SI-ATRP) on the surface of polyamide composite nanofiltration (NF) membranes and then end-capped with superparamagnetic iron oxide magnetite...
Protein-based therapeutics, in particular monoclonal antibodies (mAbs), are high demand for treating a variety of conditions. Here, membrane chromatography protein purifications is reviewed. In particular, current status and development various capture polishing steps including A, ion exchange hydrophobic interaction (HIC) discussed. addition, new developments ligand design functionalization In-depth discussions on polymeric ligands with UV-initiated polymerization or atom transfer radical...
Even though membranes can lead to more environmentally sustainable separation processes, membrane casting typically involves toxic organic solvents. Recently, there has been increasing interest in substituting these solvents for green In this study, polysulfone ultrafiltration were fabricated by nonsolvent induced phase using two green, bio-derived solvents: Cyrene and gamma-valerolactone (GVL). The effect of coagulation bath composition was investigated, with water, ethanol, water/ethanol...
Tangential flow microfiltration is easily adapted for batch and continuous bioreactor clarification. The permeate can be introduced directly to the subsequent capture step. However, commercial use of tangential filtration (TFF) limited by membrane fouling, leading a compromised performance. Here, we explored possibility reducing fouling integrating hydrocyclone as primary clarification operation. overflow from was feed module. Chinese hamster ovary cells were used stream investigate...
Background: Biologics is an exciting and growing area of medicine. Within the larger field biologics, use viral vectors virus-like particles (VLPs) increasingly common, making it crucial to develop innovative practical unit operations for related purification process. Objective: Some scientists engineers propose that membrane-based downstream virus (MVP) platforms would allow more scalable cost-effective production these critical particles. However, so-cial, political, ethical implications...
A theoretical model based on the competition between hydrogen-bonding energy and strain was constructed to explain size of native cellulose Iβ. The cellodextrins in crystalline Iα Iβ are unusually stable compared other polysaccharides, not easily prone hydrolysis even though they only nanometers diameter. stability is most likely due its greatly enhanced (HB) network. We carried out ab initio calculations determine atomic conformational structures. For cellulose, we found that every hydroxyl...