- Dialysis and Renal Disease Management
- Advanced Multi-Objective Optimization Algorithms
- Scheduling and Optimization Algorithms
- Optimal Experimental Design Methods
- Advanced Manufacturing and Logistics Optimization
- Simulation Techniques and Applications
- Vitamin C and Antioxidants Research
- Acute Kidney Injury Research
- Optimization and Packing Problems
- Supply Chain and Inventory Management
- Renal function and acid-base balance
- Erythropoietin and Anemia Treatment
- Assembly Line Balancing Optimization
- Central Venous Catheters and Hemodialysis
- Manufacturing Process and Optimization
- Antioxidant Activity and Oxidative Stress
- Flexible and Reconfigurable Manufacturing Systems
- Sustainable Supply Chain Management
- Muscle and Compartmental Disorders
- Traffic control and management
- Healthcare Operations and Scheduling Optimization
- Transportation Planning and Optimization
- Heart Rate Variability and Autonomic Control
- Advanced Graph Theory Research
- Quality and Supply Management
Sapienza University of Rome
2015-2023
San Raffaele University of Rome
2006-2022
Polytechnic University of Bari
2012-2021
IRCCS Ospedale San Raffaele
1990-2021
University of Zurich
2021
Hôpital Charles-Foix
2020
Sorbonne Université
2020
Vita-Salute San Raffaele University
1997-2020
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2020
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
1997-2020
The rapid evolution of the health emergency linked to spread severe acute respiratory syndrome coronavirus 2 requires specifications for rehabilitative management patients with disease 2019 (COVID-19). symptomatic COVID-19 is characterized by phases: an phase in which symptoms prevail and a postacute can show related prolonged immobilization, previous current dysfunctions, cognitive emotional disorders. Thus, there need specialized care these patients. This communication reports experience...
Optimization of simulated systems is the goal many methods, but most methods assume known environments. We, however, develop a “robust” methodology that accounts for uncertain Our uses Taguchi's view world replaces his statistical techniques by design and analysis simulation experiments based on Kriging (Gaussian process model); moreover, we use bootstrapping to quantify variability in estimated metamodels. In addition, combine with nonlinear programming, estimate Pareto frontier. We...
The paper proposes a decision support system (DSS) for the supply chain of packaged fresh and highly perishable products. DSS combines unique tool sales forecasting with order planning which includes an individual model selection equipped ARIMA, ARIMAX transfer function families, latter two accounting impact prices. Forecasting parameters are chosen via alternative tuning algorithms: two-step statistical analysis, sequential parameter optimisation framework automatic tuning. selects to apply...
The activity of the autonomic nervous system is noninvasively studied by means autoregressive (AR) frequency analysis heart-rate variability (HRV) signal. Some methods noise rejection and robustness for AR recursive identification are presented that make on-line signal more reliable. performance algorithms first tested through simulations, then results obtained on real data during ischemic episodes presented.
An agile and environmentally conscious manufacturing paradigm refers to the ability reconfigure a flexible system quickly, economically, responsibly. In modern enterprises, e-supply chains integrate Internet web-based electronic market are promising systems achieve agility. A key issue in strategic logistic planning of integrated (IESCs) is configuration partner network. This paper proposes single- multiobjective optimization model configure network IESCs. Considering an Internet-based...
Abstract Integrated e-supply chains are distributed manufacturing systems composed of various resources belonging to different companies and integrated with streamlined material, information financial flow. The configuration the supply-chain network is essential for business pursue a competitive advantage meet market demand. This paper proposes three-level hierarchical methodology supply chain design at planning-management level. described as set consecutive stages connected by communication...
An ACTH-containing benign adrenal medullary tumor (paraganglioma) situated within the right gland associated with bilateral hyperplasia and Cushing's syndrome is reported. The clinical chemical features were those usually an ACTH-secreting carcinoma. hyperplastic remaining after surgery did not respond to ACTH initially. Two months postoperatively it responded subnormally stimulation, but response metyrapone was demonstrated; this indicated that a responsive pituitary-adrenal mechanism...
In view of the beneficial effects reserpine and beta-adrenergic blocking agents in thyrotoxicosis, we evaluated alone seven thyrotoxic patients with eight episodes thyroid storm. All had hyperthermia, exaggerated signs symptoms. survived. Initially, 1 to 5 mg was given intramuscularly, 0.07 0.3 per kilogram body weight administered first 24 hours. Hyperthermia, hyperhidrosis, tachycardia psychologic aberrations improved within four More rapid responses were seen higher initial doses. two...
A study of urinary steroid excretion and body composition was undertaken in 40 obese patients. Eleven patients were found to be hyperexcretors on the basis 17-OHCS levels greater than 10 mg/24 hr. Total weight, lean mass surface area significantly different 2 groups patients, but no difference statistical significance between height, excess fat or creatinine demonstrated. Resting correlated best with mass, whereas following ACTH stimulation correlation total weight. No 17-KS measurements found.
The paper describes the methodology used for developing an electric load microforecasting module to be integrated in Energy Management System (EMS) architecture designed and tested within “Energy Router” (ER) project. This Italian R&D project is aimed at providing non-industrial active customers prosumers with a monitoring control device that would enable demand response through optimization of their own distributed energy resources (DERs). optimal organized hierarchical structure...
Historical linguists have identified regularities in the process of historic sound change. The comparative method utilizes those to reconstruct proto-words based on observed forms daughter languages. Can this be efficiently automated? We address task proto-word reconstruction, which model is exposed cognates contemporary languages, and has predict proto word ancestor language. provide a novel dataset for task, encompassing over 8,000 entries, show that neural sequence models outperform...
This paper deals with the issue of forecasting energy production a Photo-Voltaic (PV) plant, needed by Distribution System Operator (DSO) for grid planning. As PV plant is strongly dependent on environmental conditions, DSO has difficulties to manage an electrical system stochastic generation. implies need have reliable irradiance level next day in order setup whole distribution network. To this aim, proposes use transfer function models. The assessment quality and accuracy proposed method...
Objective: The COVID-19 pandemic has caused significant motor, cognitive, psychological, neurological and cardiological disabilities in many infected patients. Functional rehabilitation of infectious patients been implemented the acute care wards appropriate, ad hoc, multidisciplinary units. However, because units are a clinical novelty, organizational benchmarks not yet available. aim this study is to describe needs operational costs such unit, by comparing its activity, organization, with...
Optimization of simulated systems is the goal many methods, but most methods assume known environments. In this paper we present a methodology that does account for uncertain Our uses Taguchi's view world, replaces his statistical techniques by either Response Surface Methodology or Kriging metamodeling. We illustrate resulting through well-known Economic Order Quantity (EOQ) model.