A5052130451- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Forensic Toxicology and Drug Analysis
- Animal Behavior and Reproduction
- Technology Assessment and Management
- Pharmaceutical studies and practices
- Pharmacology and Obesity Treatment
- Malaria Research and Control
- Injury Epidemiology and Prevention
- Air Traffic Management and Optimization
- Epilepsy research and treatment
- Poisoning and overdose treatments
- Aerospace Engineering and Control Systems
- Animal Vocal Communication and Behavior
- Defense, Military, and Policy Studies
- Cannabis and Cannabinoid Research
- Organ Donation and Transplantation
- Sports injuries and prevention
- Pharmacological Effects and Toxicity Studies
- Psychedelics and Drug Studies
- Methane Hydrates and Related Phenomena
- Cardiovascular Effects of Exercise
- Immunotherapy and Immune Responses
- Health Systems, Economic Evaluations, Quality of Life
- Corneal surgery and disorders
UNSW Sydney
1982-2023
St Vincent's Hospital Sydney
1998-2022
St Vincent's Hospital
1978-2021
St Vincent's Clinic
2018-2020
Miami University
2020
The University of Sydney
2018
Victoria University
2018
Manly Hospital
1990-2018
University of South Australia
2018
The University of Notre Dame Australia
2018
ABSTRACT Apical membrane antigen 1 (AMA1) is regarded as a leading malaria blood-stage vaccine candidate. While the overall structure of AMA1 conserved in Plasmodium spp., numerous allelic variants P. falciparum have been described. The effect diversity on ability recombinant to protect against human infection by different strains unknown. We characterize two forms that were both produced Pichia pastoris at sufficient economy scale be usable for clinical studies. Both proteins used immunize...
ABSTRACT A major challenge facing malaria vaccine development programs is identifying efficacious combinations of antigens. To date, merozoite surface protein 1 (MSP1) regarded as the leading asexual candidate. Apical membrane antigen (AMA1) has been identified another candidate for an vaccine, but without any direct in vivo evidence that a recombinant form Plasmodium falciparum AMA1 would have efficacy. We evaluated efficacy P. AMA1, produced Pichia pastoris , by vaccinating Aotus...
Objective To examine the relationship between anabolic steroid abuse and cardiac death. We report first two cases in Australia. They are only reported which oxymesterone has been detected. This compound never approved for use Clinical features Two footballers, aged 18 24, sustained fatal arrests while at training sessions. Both were considered fit healthy. Outcome Autopsy revealed of a hypertrophic cardiomyopathy 18-year-old; 24-year-old had findings myocarditis. In both coronary arteries...
Hypertriglyceridemia, peripheral insulin resistance, and trunk adiposity are metabolic complications recently recognized in people infected with human immunodeficiency virus (HIV) treated highly active antiretroviral therapy (HAART). These may respond favorably to exercise training. Using a paired design, we determined whether 16 wk of weight-lifting increased muscle mass strength decreased fasting serum triglycerides adipose tissue 18 HIV-infected men. The resistance regimen consisted three...
Abstract Unilateral enucleations were performed on larval, transforming and adult sea lampreys. Following 5 to 11 days survival, the animals sacrificed brains processed using a modified Fink‐Heimer technique. In larvae, contralateral optic projections found posterior one‐third of dorsal thalamus, pretectum, tectum. No ipsilateral present in larvae. enucleated lampreys, degenerating axons observed chiasm bilaterally tracts. Retinal efferents projected lateral neuropil region (“tractus...
Two strains of transgenic mice have been generated that secrete into their milk a malaria vaccine candidate, the 42-kDa C-terminal portion Plasmodium falciparum merozoite surface protein 1 (MSP1(42)). One strain secretes an MSP1(42) with amino acid sequence homologous to FVO parasite line, other where two putative N-linked glycosylation sites in removed. Both forms were purified from whole greater than 91% homogeneity at high yields. proteins are recognized by panel monoclonal antibodies and...
To document adverse effects of anabolic-androgenic steroid (AAS) use in community-based users attending a medical clinic.Prospective recruitment, questionnaire-based interview, physical examination and investigations, with follow-up, people who attended, anonymously, an inner-city hospital clinic established specifically to examine AAS use.58 men, comprising 27 past users, 14 present 17 potential (who formed the control group).Clinical abnormal laboratory findings.Cyclical oral...
Abstract An AOAC International-International Union of Pure and Applied Chemistry-International Fruit Juice (AOAC-IUPAC-IFJU) collaborative study was conducted to evaluate a liquid chromatographic (LC) procedure for determination patulin in apple juice. Patulin is mold metabolite found naturally rotting apples. extracted with ethyl acetate, treated sodium carbonate solution, determined by reversed-phase LC UV detection at 254 or 276 nm. Water, water-tetrahydrofuran, water-acetonitrile used as...
A blood-stage vaccine based on Plasmodium falciparum merozoite surface protein 3 (MSP3) was tested for efficacy in a primate model. Aotus nancymai monkeys were vaccinated with yeast-expressed MSP3 before lethal challenge parasites. Five of 7 control had acute infections and required treatment to parasitemia. Only 1 this treatment. The the vaccination appeared be comparable that MSP142, leading asexual candidate, response which 2 experienced infections. In MSP3-vaccinated group, protection...
Interleukin-1 receptor antagonist (IL-1ra) is an important modulator of IL-1 activity in a variety tissues. IL-1ra differentially produced by different cell types as 22-26-kD secreted peptide (sIL-1ra) and/or smaller 16- or 18-kD intracellular (icIL-1ra). This study was undertaken to evaluate the production human cornea. mRNA can be detected early passage corneal epithelial cells and stromal fibroblasts significantly enhanced IL-1. Corneal endothelial do not express mRNA. Immunohistochemical...
Protection against Plasmodium falciparum can be induced by vaccination in animal models with merozoite surface protein 1 (MSP1), which makes this an attractive vaccine candidate for malaria. In attempt to produce a product that is easily scaleable and inexpensive, we expressed the C-terminal 42 kDa of MSP1 (MSP1(42)) Escherichia coli, refolded its native form from insoluble inclusion bodies, tested ability elicit antibodies vitro vivo activities. Biochemical, biophysical, immunological...
Abstract Background Advanced treatments for IBD typically have placebo-adjusted clinical remission rates of only 10 to 25%. The combined use targeted biologic agents could break through this efficacy ceiling while avoiding the risks associated with broad immunosuppression. Spyre Therapeutics is developing fully human half-life extended IgG1 antibody drug candidates that can be used in combination against clinically validated targets, including α4β7 integrin (SPY001) and TL1A (SPY002)....
Abstract We have previously shown that transgenic (Tg) mice expressing either soluble or membrane-bound hen egg lysozyme (sHEL mHEL, respectively) under control of the αA-crystallin promoter develop tolerance due to thymic expression minuscule amounts HEL. To further address mechanisms by which this develops, we mated these two lines Tg with 3A9 line HEL-specific TCR mice, produce double-Tg mice. Both showed deletion T cells, demonstrated reduction in numbers cells thymus and periphery, as...
Over recent years the depth to which we have grown rely on networked computer systems as part of critical national infrastructure has become ever more apparent. Concern over difficulties caused by accidental failures led a realisation potential for damage that could be targeted attacks and cyber warfare. Current approaches addressing these problems tended focus traditional security measures, not mobilised full breadth capabilities provided digital technologies. In this paper will explore...
CCR5 is the major coreceptor for human immunodeficiency virus (HIV) infection. The murine monoclonal antibody (MAb) 2D7, which recognizes a conformation-dependent epitope in second extracellular loop of CCR5, one most potent inhibitors R5 cell entry. However, attempts to humanize 2D7 vivo use have been unsuccessful so far. A filamentous phage library expressing random peptides was used identify peptide mimitope that recognized by MAb 2D7. synthetic containing this sequence (2D7-2SK) bound...
Influenza A virus (FLUAV), the causative agent of influenza infection, has received extensive attention due to recent swine-origin H1N1 pandemic. FLUAV long been cause annual epidemics as well less frequent but more severe global pandemics. Here, we describe a biosensor utilizing electrically active magnetic (EAM) polyaniline-coated nanoparticles transducer in an electrochemical for rapidly identifying strains based on receptor specificity, which will be useful monitor animal infections and...