A5018041015- Chemotherapy-induced cardiotoxicity and mitigation
- Antioxidant Activity and Oxidative Stress
- Peptidase Inhibition and Analysis
- Synthesis and Biological Evaluation
- Atherosclerosis and Cardiovascular Diseases
University of Kansas Medical Center
2021-2025
University of Kansas
2023
Alpha-1 antitrypsin deficiency (AATD) is underdiagnosed, with a significant gap between documented cases and estimated prevalence. Attempts to bridge this include published guidelines emphasising the importance of screening for AATD educational campaigns directed public. Early detection has clinical ramifications optimal management patient AATD, as well prevention disease in affected family members through early modification environmental factors. Our case report describes minimally...
The toxicity of doxorubicin to the cardiovascular system often limits its benefits and widespread use as chemotherapy. mechanisms involved in doxorubicin-induced damage possible protective interventions are not well-explored. Using human aortic endothelial cells, we show vitamin D3 strongly attenuates senescence cell cycle arrest. We further effects mediated by upregulation IL-10 FOXO3a expression through fine modulation pAMPKα/SIRT1/FOXO3a complex activity. These results have great...
Doxorubicin, an anthracycline chemotherapeutic known to incur heart damage, decreases function in up 11% of patients. Recent investigations have implicated the Wnt signaling cascade as a key modulator cardiac tissue repair after myocardial infarction. upregulation murine models resulted stimulation angiogenesis and suppression fibrosis ischemic insult. However, molecular mechanisms mitigating doxorubicin-induced insult require further investigation. Identifying cardioprotective is imperative...