A5082087693- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Chemical synthesis and pharmacological studies
- Click Chemistry and Applications
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
Jamia Hamdard
2008-2012
Several substituted phenoxy acetic acid derived pyrazolines were synthesized by the reaction between 2-{4-[3-(2,4-dihydroxyphenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy} and hydrazides tested for their in vitro cytotoxicity antiviral activity. None of compounds showed any specific activity [50% antivirally effective concentration (EC(50)) > or = 5-fold lower than minimum cytotoxic concentration]. The most series was...
3-Chlorobenzofuran-2-carbaldehyde was condensed with substituted acetophenone by using the Claisen-Schmidt condensation to obtain 3-(3-chlorobenzofuran-2-yl)-1-(substituted phenyl)-2-propen-1-one (2a-m) which upon further treatment hydrazine hydrate gave 2-[3-(substituted phenyl)-4,5-dihydro-1H-5- pyrazolyl)benzofuran-3-yl chloride derivatives (3a-m). All newly synthesized were evaluated in vitro for cytotoxicity and antiviral activity Crandell-Rees Feline Kidney cell, human embryonic lung...
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Abstract: Epilepsy is a chronic neurological disorder characterized by periodic and unpredictable seizures affecting the neurobiological, psychological, cognitive, economic, social well-being of patients. It one causes concern in developed as well developing countries currently marketed drugs are not capable providing protection against it. Although several heterocyclic moieties have been frequently used building blocks for preparation anticonvulsant drugs, more focused consistent research...