A5085128245- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Gout, Hyperuricemia, Uric Acid
- Biomedical Research and Pathophysiology
- Alkaline Phosphatase Research Studies
- Paleopathology and ancient diseases
- Porphyrin Metabolism and Disorders
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Radioactive element chemistry and processing
- Erythrocyte Function and Pathophysiology
- Endodontics and Root Canal Treatments
- Inorganic and Organometallic Chemistry
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Connexins and lens biology
- Aldose Reductase and Taurine
- Asymmetric Synthesis and Catalysis
- Bone health and osteoporosis research
- Chemical Synthesis and Reactions
- Fluorine in Organic Chemistry
- Lipid Membrane Structure and Behavior
- Ion Transport and Channel Regulation
- Alcohol Consumption and Health Effects
- Veterinary medicine and infectious diseases
- Connective tissue disorders research
Medical College of Wisconsin
2001-2023
Milwaukee VA Medical Center
1987-2017
University of Chicago
1996
The University of Texas Southwestern Medical Center
1994
Hospital for Special Surgery
1992
Veterans Health Administration
1992
King Faisal Specialist Hospital & Research Centre
1989
United States Military Academy
1987
Merck & Co., Inc., Rahway, NJ, USA (United States)
1987
Arthritis Foundation
1981-1984
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric acylation reactions of chiral imide enolates. The first direct approach to the construction .beta.-dicarbonyl synthonsD. A. Evans, M. D. Ennis, T. Le, N. Mandel, and G. MandelCite this: J. Am. Chem. Soc. 1984, 106, 4, 1154–1156Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February...
No AccessJournal of Urology1 Dec 1989Urinary Tract Stone Disease in the United States Veteran Population. II. Geographical Analysis Variations Composition Neil S. Mandel, and Gretchen Mandel MandelNeil , MandelGretchen View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39145-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The geographical distribution crystalline components observed urinary tract stones...
Crystal polymorphism is exhibited by calcium oxalates in nephrolithiasis, and we have proposed that a shift the preferred crystalline form of oxalate (CaOx) from monohydrate (COM) to dihydrate (COD) induced urinary macromolecules reduces crystal attachment epithelial cell surfaces, thus potentially inhibiting critical step genesis kidney stones. We tested validity this hypothesis studying both binding crystals renal tubule cells effect macromolecular solutes on structure. Renal grown culture...
Abstract Hydroxyapatite crystals in spheroid‐shaped masses 1.9–15.6m̈ diameter were found 12 of 13 synovial fluids obtained from the shoulder joints 4 patients with rotator cuff tears and glenohumeral osteo‐arthritis. Two 16 control joint also showed these particles. Collagen types I, II, III identified fluid pellets 3 patients, fibers typical collagen periodicity seen on transmission electronmicroscopy. Collagenase neutral protease activities 5 whereas active collagenase was only 1 10...
We have used published rat micropuncture data to construct a matrix of ion concentrations along the nephron. With an iterative computer model known interactions, we calculated relative supersaturation ratios in all nephron segments. The collecting ducts and urine showed expected with stone-forming salts. Fluid thin segment loop Henle may be supersaturated calcium carbonate phosphate under certain conditions. Because calculations cannot predict actual course crystallization, made solutions...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMonosodium urate monohydrate, the gout culpritNeil S. Mandel and Gretchen MandelCite this: J. Am. Chem. Soc. 1976, 98, 8, 2319–2323Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://pubs.acs.org/doi/10.1021/ja00424a054https://doi.org/10.1021/ja00424a054research-articleACS PublicationsRequest reuse permissionsArticle Views647Altmetric-Citations99LEARN ABOUT THESE METRICSArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA kinetic and x-ray diffraction study of the solid state rearrangement methyl p-dimethylaminobenzenesulfonate. Reaction rate enhancement due to proper orientation in a crystalChaim N. Sukenik, Jose A. P. Bonapace, Neil S. Mandel, Pui-Yan Lau, Gordon Wood, Robert G. BergmanCite this: J. Am. Chem. Soc. 1977, 99, 3, 851–858Publication Date (Print):February 1, 1977Publication History Published online1 May 2002Published inissue 1 February...
Ectopic calcification is a driving force for variety of diseases, including kidney stones and atherosclerosis, but initiating factors remain largely unknown. Given its importance in seemingly divergent disease processes, identifying fundamental principal actors ectopic may have broad translational significance. Here we establish Drosophila melanogaster model by inhibiting xanthine dehydrogenase whose deficiency leads to humans dogs. Micro X-ray absorption near edge spectroscopy (μXANES)...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jun 2003Conversion Calcium Oxalate to Phosphate With Recurrent Stone Episodes NEIL MANDEL, IAN KATHY FRYJOFF, TAMMY REJNIAK, and GRETCHEN MANDEL MANDELNEIL , MANDELIAN FRYJOFFKATHY FRYJOFF REJNIAKTAMMY REJNIAK MANDELGRETCHEN View All Author Informationhttps://doi.org/10.1097/01.ju.0000065592.55499.4eAboutFull TextPDF ToolsAdd favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvergent synthesis of polyether ionophore antibiotics: an approach to the monensin tetrahydropyran-bis(tetrahydrofuran) via ester enolate Claisen rearrangement and reductive decarboxylationRobert E. Ireland, Daniel W. Norbeck, Gretchen S. Mandel, Neil MandelCite this: J. Am. Chem. Soc. 1985, 107, 11, 3285–3294Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1...
Abstract Objective. To identify the morphology of a mineral‐forming fraction adult porcine hyaline articular cartilage digest and characterize mineral it forms. Methods. Electron microscopy, Fourier transform infrared (FTIR) spectroscopy, x‐ray microanalysis, compensated polarized light biochemical studies including 14 C‐labeled UDPG pyrophosphohydrolase radiometric assay. Results. This contained membrane‐limited vesicles resembling growth plate matrix formed after only 24 hours in...
The development of urolithiasis is a multifaceted process, starting at urine supersaturation and ending with the formation mature renal calculi. retention microcrystals by urothelial cell membrane critical event in process. current study examines calcium oxalate monohydrate (COM) crystal attachment to inner medullary collecting duct (IMCD) cells following selective changes phospholipid composition. Both primary culture IMCD continuous line were used for these studies. Cell composition was...
Attachment of microcrystallites to cellular membranes may be an important component the pathophysiology many diseases including urolithiasis. This study attempts characterize interaction calcium oxalate (CaOx) crystals and apatite (AP) with renal papillary collecting tubule (RPCT) cells in primary culture. Primary cultures RPCT showed characteristic monolayer growth sporadically interspersed clumped cells. Cultures were incubated [14C]CaOx crystals, that bound quantified by microscopy...
The relationship between cell membrane polarity and calcium oxalate (CaOx) crystal binding was studied in rat renal inner medullary collecting duct (IMCD) cells primary culture. Cultures grew as simple monolayers (M) with interspersed cellular aggregates (A), CaOx bound preferentially to A. An antibody that recognizes an exclusively basolateral epitope intact IMCD binds some of the A but not M. Lysing intercellular junctions 3 mM EGTA (monitored by transepithelial resistance, R) resulted...
✓ Tophaceous pseudogout is one of the rarest forms crystal deposition disease, typically presenting as a destructive and invasive mass involving temporomandibular joint or infratemporal fossa region in absence any other articular manifestations. Previous cases have been assumed to be caused by calcium pyrophosphate dihydrate (CPPD) deposition, based on finding weakly birefringent crystals involved tissues. The authors present unique case 65-year-old woman with facial extending middle cranial...
Journal Article Urinary Tract Calculi Get access Neil Mandel, PhD Medical College of Wisconsin, Zablocki Veterans Administration Center, Milwaukee, Wl 53193. Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 17, Issue 8, 1 August 1986, Pages 449–458, https://doi.org/10.1093/labmed/17.8.449 Published: 01 1986
Abstract Background: Although nephrotoxic in high doses, ethylene glycol (EG) has been used with ammonium chloride (NH 4 Cl) or vitamin D 3 to study calcium oxalate stone formation rat models. In the present we EG alone NH Cl hyperoxaluria, crystaluria, and crystal attachment renal epithelial cells rats minimal damage. Methods: Six‐week‐old male Sprague–Dawley (SD) were given food special drinking water. experiment 1 water contained 1.0% plus four different concentrations of (0.8%, 0.4%,...
In order to identify the physical and structural parameters that relate best membranolytic, inflammatory, fibrotic potentials of different silicon dioxide (SiO2) titanium (TiO2) crystals, we have studied potential four SiO2 two TiO2 crystal structures lyse human red blood cells induce pulmonary inflammation fibrosis in mice. The crystals were quartz, tridymite, cristobalite, coesite, anatase, rutile. Mice injected intratracheally with each at constant surface area. Inflammation assessed 6 wk...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies relating to the alleged structure of cannivonine and synthetically derived (.+-.)-dihydrocannivonineDavid A. Evans, Alan M. Golob, Neil S. Mandel, Gretchen MandelCite this: J. Am. Chem. Soc. 1978, 100, 26, 8170–8174Publication Date (Print):December 1, 1978Publication History Published online1 May 2002Published inissue 1 December 1978https://doi.org/10.1021/ja00494a025RIGHTS & PERMISSIONSArticle Views354Altmetric-Citations48LEARN ABOUT THESE...