A5063420295- Neurotransmitter Receptor Influence on Behavior
- Zebrafish Biomedical Research Applications
- Biosensors and Analytical Detection
- Advanced Biosensing Techniques and Applications
- 3D Printing in Biomedical Research
- Veterinary Pharmacology and Anesthesia
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects and Assays
- Sleep and Wakefulness Research
University of Verona
2022-2023
In an effort to find alternatives study in vivo the so-called New Psychoactive Substances (NPS), present work was undertaken investigate use of zebrafish larvae as animal model pharmaco-toxicology, providing behavioural and metabolism information. For this purpose, fentanyl, progenitor extremely dangerous group NPS, administered at different doses (1, 10, 50, 100 µM) comparison mice (0.1, 1, 6, 15 mg/kg), a well-established model. A assay performed time peak effect showing that results are...
Abstract The use of novel psychoactive substances (NPSs) has dramatically increased worldwide, and among them, synthetic opioids are one the fastest growing groups, where cinnamylpiperazines 2‐benzylbenzimidazoles represent two most relevant subclasses. However, data on their toxicity metabolism still limited. aim present study was to evaluate metabolic pathways some compounds belonging these families, namely, AP‐237, 2‐methyl isotonitazene, flunitazene, etodesnitazene, metonitazene,...
The introduction of the so-called New Psychoactive Substances represents a problem global concern due to several factors, including multiplicity structures, poorly known activity, short half-life in market, lack pure standards etc. Among these problems, highest relevance is also information about metabolism and adverse effects, which must be faced using simple low-cost animal models. On grounds, present work has been carried out on 5 days post fertilization zebrafish (Danio rerio) larvae...