Laura Casula

ORCID: 0000-0001-5838-2230
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About
Contact & Profiles
Research Areas
  • Autism Spectrum Disorder Research
  • Family and Disability Support Research
  • Genetics and Neurodevelopmental Disorders
  • Attention Deficit Hyperactivity Disorder
  • Child Nutrition and Feeding Issues
  • Child Development and Digital Technology
  • Colorectal Cancer Treatments and Studies
  • Hepatocellular Carcinoma Treatment and Prognosis
  • School Choice and Performance
  • Endodontics and Root Canal Treatments
  • HIV Research and Treatment
  • Genetic Associations and Epidemiology
  • Energy Load and Power Forecasting
  • Systemic Sclerosis and Related Diseases
  • Inflammatory Bowel Disease
  • Electric Power System Optimization
  • Angiogenesis and VEGF in Cancer
  • melanin and skin pigmentation
  • Transcranial Magnetic Stimulation Studies
  • RNA regulation and disease
  • Bone Metabolism and Diseases
  • Wind Energy Research and Development
  • Genetic and phenotypic traits in livestock
  • Therapeutic Uses of Natural Elements
  • Skin Protection and Aging

Bambino Gesù Children's Hospital
2015-2025

Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025

University of Cagliari
2008-2024

Universidade Estadual Paulista (Unesp)
2024

Azienda Ospedaliero-Universitaria Cagliari
2022-2023

Cairo University
2019

Creative Research Enterprises (United States)
2019

University of Rome Tor Vergata
2019

Boston Children's Hospital
2015

Osservatorio Astronomico di Cagliari
2013

Abstract Background & Aims Malnutrition with the accumulation of fat tissue and nonalcoholic fatty liver disease (NAFLD) are conditions associated inflammatory bowel (IBD). Visceral NAFLD-related dysfunction can both worsen intestinal inflammation. Because Mediterranean diet (Md) has been shown to ameliorate obesity NAFLD, aim this study was analyze impact Md on nutritional state, steatosis, clinical activity, quality life (QoL) in IBD patients. Methods Patients IBD, Crohn’s (CD)...

10.1093/ibd/izaa097 article EN cc-by-nc Inflammatory Bowel Diseases 2020-05-22

Nonalcoholic fatty liver disease (NAFLD) is a frequently reported condition in patients with inflammatory bowel (IBD). Both intestinal inflammation and metabolic factors are believed to contribute the pathogenesis of IBD-associated NAFLD.To evaluate prevalence steatosis fibrosis (LF) cohort IBD identification metabolic- IBD-related risk for NAFLD LF.IBD were consecutively enrolled from December 2016 January 2018. Demographic, anthropometric biochemical data collected so as eating habits....

10.3748/wjg.v25.i37.5676 article EN cc-by-nc World Journal of Gastroenterology 2019-09-28

Abstract Objectives This randomized, controlled, pilot study assessed the outcome of non-surgical primary/secondary root canal treatments either with a novel bioactive sealer and single-cone technique or gutta-percha, zinc oxide-eugenol (ZOE), warm vertical compaction. Materials methods Sixty-nine patients were randomly divided into two groups that treated using BioRoot TM RCS (Septodont) (BIO group) compaction gutta-percha ZOE (PCS group). Two subsamples (BIOAP PCSAP) comprised cases apical...

10.1007/s00784-020-03590-0 article EN cc-by Clinical Oral Investigations 2020-09-28

This study investigated the prevalence and distribution of psychiatric comorbidities in a group 472 children adolescents with ASD aged 3-18 years. We examined differences age, sex, IQ, adaptive skills, symptom severity by comparing participants (ASD group) disorder (ASD/PSY group). Overall, 32.2% had comorbid condition. Attention deficit/hyperactivity (ADHD) was most frequent diagnosis among preschoolers (20.4%); school-age children, ADHD anxiety/obsessive-compulsive disorders were...

10.3390/jcm12020677 article EN Journal of Clinical Medicine 2023-01-14

Background Thrombocytopenia is a common finding in several diseases but almost nothing known about the prevalence of thrombocytopenia general population. We examined and determinants platelet count healthy population with wide age range.Design Methods performed cross-sectional study on 12,517 inhabitants ten villages (80% residents) secluded area Sardinia (Ogliastra). Participants underwent complete blood evaluation structured questionnaire, used to collect epidemiological data.Results...

10.3324/haematol.2010.029934 article EN cc-by-nc Haematologica 2010-09-07

Introduction Autistic individuals may show several psychiatric co-occurrences, including Feeding and Eating Disorders (FEDs). Avoidant Restrictive Food Intake Disorder (ARFID) consists of avoidance or restriction in food intake, leading to significant weight loss, nutritional deficiencies, marked interference with psychosocial functioning. Both Autism Spectrum (ASD) ARFID are characterized by the two main features cognitive rigidity sensory sensitivity, which complicate differential...

10.3389/fpsyt.2024.1447562 article EN cc-by Frontiers in Psychiatry 2025-01-24

Autism spectrum disorder (ASD) is a neurodevelopmental characterized by persistent deficits in social interaction and repetitive behaviors (RBs). Therapies specifically targeting RBs have been underexplored despite advances understanding their neurobiological basis. This study aims to evaluate whether high-definition transcranial direct current stimulation (HD-tDCS) can reduce dysfunctional autistic children investigate improvements differ between lower-order higher-order based on the brain...

10.1186/s12888-025-06506-y article EN cc-by-nc-nd BMC Psychiatry 2025-02-25

Introduction It is recognized that around 25-30% of autistic children do not develop functional speech and remain minimally verbal beyond the age 5. However, little known about clinical characteristics this group. Methods We retrospectively examined a sample 189 adolescents classified as (mean age: 7.37 ± 1.51; 152 males, 37 females) compared them with group 184 7.71 2.52; 160 24 females). considered intellectual functioning, severity autism, emotional behavioural problems, parenting stress....

10.3389/fpsyt.2025.1549092 article EN cc-by Frontiers in Psychiatry 2025-03-20

Impairments of motor representation actions have been reported as a core component Autism Spectrum Disorders (ASD). Individuals with ASD difficulties in number functions such assuming anticipatory postures, imitating body movements, producing and understanding gestures, recognizing intentions. Such cognitive-motor abilities are all involved pantomime. However, the available evidence on production comprehension pantomime individuals is still inconclusive. The current investigation assessed...

10.3389/fpsyg.2019.01382 article EN cc-by Frontiers in Psychology 2019-06-18

Objective The objective of this paper is to evaluate hospital admissions in systemic lupus erythematosus (SLE) patients through a retrospective population-based study analyzing hospitalization data during 2001–2012 Sardinia, an Italian region with universal health system coverage. Methods Data on the discharge records ICD-9-CM code for SLE (710.0) were obtained from Department Health and Hygiene analyzed, mostly focusing primary non-primary diagnosis Diagnosis-Related Group (DRG) code. In...

10.1177/0961203315596597 article EN Lupus 2015-07-20

The low Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet has demonstrated excellent results in terms of symptom control health-related quality life (HRQoL) irritable bowel syndrome (IBS) sufferers, but patients have complained about unsatisfying taste, difficulty following the diet, time consumption. To investigate feasibility FODMAP an Italian (Sardinian) cohort, sixty consecutive eligible outpatients (11 men 49 women) with IBS were enrolled followed a...

10.3390/nu12030716 article EN Nutrients 2020-03-08

Endometriosis is a chronic inflammatory disease of women reproductive age. Small bowel (SB) permeability and lipopolysaccharides (LPS) could play role in the perduration low grade inflammation status pathogenesis endometriosis. To clarify this hypothesis, we measured SB through plasma values LPS urinary secretion lactulose (La), mannitol (Ma) their ratio (L/M) patients with endometriosis compared healthy controls (HC). Eight 14 HC entered study. was evaluated by high-performance liquid...

10.1080/09513590.2020.1766440 article EN Gynecological Endocrinology 2020-05-13

Abstract Aim This randomized clinical trial assessed the outcomes of nonsurgical root canal treatment (RCT), comparing a calcium silicate‐based sealer (CSBS) with single‐cone technique (SC) zinc oxide‐eugenol (ZOE) and warm vertical compaction (WVC). Methodology Ninety‐two single‐ multi‐rooted teeth were divided into two groups treated using either SC BioRoot™ RCS (BIO) or WVC Pulp Canal Sealer™ EWT (PCS). Teeth apical periodontitis (AP) in both further BIOAP PCSAP subgroups. Standardized...

10.1111/iej.14167 article EN cc-by-nc-nd International Endodontic Journal 2024-12-10

Lentiviral‐mediated β‐globin gene transfer successfully treated β‐thalassemic mice. Based on this result, clinical trials were initiated. To date, however, no study has investigated the efficacy of therapy in relation to nature different mutations found patients. Most can be classified as β 0 or + , based amount protein produced. Therefore, we propose that a screening vitro is necessary verify prior treatment individual We used two‐phase liquid culture system expand and differentiate...

10.1111/j.1749-6632.2010.05594.x article EN Annals of the New York Academy of Sciences 2010-08-01
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