The effects of pergolide, a mixed D1/D2 receptor agonist, and bromocriptine, selective D2 were assessed in visual delay task to further investigate the "dopamine link" working memory humans look for differential D1 versus contributions. Two groups 32 healthy young adults (16 female) received either 0.1 mg pergolide or 2.5 bromocriptine placebo-controlled cross-over design. A pretreatment with domperidone, peripherally active antagonist, was performed both reduce side effects. Interindividual...

Here we present a high-resolution functional magnetic resonance (fMRI) dataset - 20 participants recorded at high field strength (7 Tesla) during prolonged stimulation with an auditory feature film ("Forrest Gump"). In addition, comprehensive set of auxiliary data (T1w, T2w, DTI, susceptibility-weighted image, angiography) as well measurements to assess technical and physiological noise components have been acquired. An initial analysis confirms that these can be used study common...

Using event-related fMRI, we analyzed the functional neuroanatomy of covert reorienting and inhibition return (IOR). Covert to a target appearing within 250 msec after an invalid contralateral location cue elicited increased activation in left fronto-polar cortex (LFPC), right anterior posterior middle frontal gyrus, cerebellum, areas that have previously been associated with attentional processes, specifically change. In contrast, IOR, which leads prolonged response times targets appear at...

The authors found splenial lesions to be associated with left ear suppression in dichotic listening of consonant-vowel syllables.This was both a rapid presentation monitoring task and standard task, ruling out attentional limitations the processing high stimulus loads as confounding factor.Moreover, directed attention did not improve target detection patients, independent callosal lesion location.The authors' data may indicate that auditory fibers pass through splenium more posterior than...

The dopaminergic system is known to play a central role in reward-based learning (Schultz, 2006), yet it was also observed be involved when only cognitive feedback given (Aron et al., 2004). Within the domain of information-integration category learning, which information from several stimulus dimensions has integrated predecisionally (Ashby and Maddox, 2005), importance contingent well established (Maddox 2003). We examined common neural correlates reward anticipation prediction error this...

To process information selectively and to continuously fine-tune selectivity of processing are important abilities for successful goal-directed behavior. One phenomenon thought represent this fine-tuning conflict adaptation effects in interference tasks, i.e. reduction after an incompatible trial when trials frequent. The neurocognitive mechanisms these currently only partly understood results from brainimaging studies so far mixed. In our study we validate extend recent findings by...

Abstract Activation of parietal cortex structures like the precuneus is commonly observed during explicit memory retrieval, but role cortices in encoding has only recently been appreciated and still poorly understood. Considering importance human visual attention imagery, we aimed to assess a potential for visuospatial representations into long‐term memory. We therefore investigated acquisition constant versus repeatedly shuffled configurations icons on background images over five subsequent...

Abstract Objects characterized by a unique visual feature may pop out of their environment. When participants have to search for such “odd-one-out” targets, detection is facilitated when targets are consistently defined within the same dimension (e.g., color) compared with target uncertain color or motion). Further, dimensional uncertainty, there cost given in different preceding target, relative critical remains same. Behavioral evidence suggests that change involves shift attention new...

The authors found splenial lesions to be associated with left ear suppression in dichotic listening of consonant-vowel syllables. This was both a rapid presentation monitoring task and standard task, ruling out attentional limitations the processing high stimulus loads as confounding factor. Moreover, directed attention did not improve target detection patients, independent callosal lesion location. authors' data may indicate that auditory fibers pass through splenium more posterior than...

Abstract The aim of this study was to investigate the neural correlates functional distinction underlying attentional mechanisms endogenous‐sustained and exogenous‐transient spatial selection. We recorded event related potentials (ERPs) used magnetic resonance imaging (fMRI) in separate experiments while subjects performed a simple reaction time (RT) same visual stimulus displayed one several field locations. Endogenous‐sustained or focusing attention onto target location were obtained by...

A "target template", specifying target features, is thought to benefit visual search performance. Setting up a "negative distractor should improve inhibition and also detection. In the current fMRI study, subjects were required for among distractors enclosed in coloured circles. Before search, one of three colour cues appeared: positive cue indicating will appear same colour, negative only or neutral that not display. results revealed down-regulation neural processing large parts cortex...

Abstract Multiple brain areas along the ventral pathway have been known to represent face images. Here, in a magnetoencephalography (MEG) experiment, we show dynamic representations of face-related eye movements absence image perception. Participants followed dot presented on uniform background, movement which represented gaze tracks acquired previously during their free-viewing and house pictures. We found dominant role stream representing tracks, starting from orbitofrontal cortex (OFC)...

Perceptual learning involves the specific and relatively permanent modification of perception following a sensory experience. In psychophysical experiments, specificity effects to trained stimulus attributes (e.g., visual field position or orientation) is often attributed assumed neural modifications at an early cortical site within processing hierarchy. We directly investigated correlate perceptual in primary cortex using fMRI. Twenty volunteers practiced curvature discrimination on...

Abstract Repeated display configurations improve visual search. Recently, the question has arisen whether this contextual cueing effect (Chun & Jiang, 1998) is itself mediated by attention, both in terms of selectivity and processing resources deployed. While it accepted that selective attention modulates (Jiang Leung, 2005), there an ongoing debate affected a secondary working memory (WM) task, specifically at which stage WM influences effect: acquisition configural associations (e.g.,...