A5015641023- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Lymphoma Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Infective Endocarditis Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Cardiac Structural Anomalies and Repair
- Viral-associated cancers and disorders
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Cardiovascular Health and Risk Factors
- Vector-Borne Animal Diseases
- T-cell and Retrovirus Studies
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
Sanjivani Super Speciality Hospitals
2014-2025
GLA University
2023-2025
Gujarat University
2021-2024
B.J. Medical College
2014-2024
Ahmedabad Civil Hospital
2015-2024
Sterling Hospitals
2020-2024
Institute of Medical Sciences
2016-2024
Bennett University
2024
Apollo Hospitals
2017-2024
Indian Institute of Management Indore
2024
<h3>Importance</h3> Hospitalized patients with COVID-19 are at risk for venous and arterial thromboembolism death. Optimal thromboprophylaxis dosing in high-risk is unknown. <h3>Objective</h3> To evaluate the effects of therapeutic-dose low-molecular-weight heparin (LMWH) vs institutional standard prophylactic or intermediate-dose heparins hospitalized COVID-19. <h3>Design, Setting, Participants</h3> The HEP-COVID multicenter randomized clinical trial recruited adult D-dimer levels more than...
ANTHEM-HF evaluated a novel autonomic regulation therapy (ART) via either left or right vagus nerve stimulation (VNS) in patients with heart failure (HF) and reduced ejection fraction (HFrEF).Sixty subjects (New York Heart Association [NYHA] functional class II-III, ventricular (LVEF) ≤ 40%, end-diastolic diameter ≥ 50 mm to < 80 mm) receiving optimal pharmacologic were randomized at 10 sites. VNS systems randomly implanted on the (n = 31) 29) side. All successfully 59 titrated over weeks...
ABSTRACT Targeted disruption of the homeobox gene T/ebp (Nkx2.1, Ttf1, Titf1) in mice results ablation pituitary. Paradoxically, while is expressed ventral diencephalon during forebrain formation, it not Rathke’s pouch or pituitary gland at any time embryogenesis. Examination development homozygous null mutant embryos revealed that a rudiment initially formed but eliminated by programmed cell death before formation definitive pouch. In mutant, Bmp4 expression maintained, whereas Fgf8...
ObjectiveEvaluate the effects of a novel autonomic regulation therapy (ART) via vagus nerve stimulation (VNS) in patients with chronic heart failure (HF) and reduced left ventricular ejection fraction during 12-month follow-up period.MethodsThe Autonomic Regulation Therapy for Improvement Left Ventricular Function Heart Failure Symptoms (ANTHEM-HF) study enrolled 60 subjects New York Association class II-III HF low (≤40%), who received open-loop ART using VNS randomized to or right cervical...
A BSTRACT Introduction: Cannabis is one of the most widely used psychoactive substances globally, with an increasing trend in its legalization for both medical and recreational purposes various countries. While cannabis offers potential therapeutic benefits, regular use can lead to development Use Disorders (CUDs). Understanding epidemiology CUDs crucial assessing public health burden associated use. Methods: Epidemiological parameters were assessed using Global Burden Disease (GBD)...
Somatostatin (SST) analogs inhibit tumor cell growth by exerting direct anti-proliferative effects with cytostatic (growth arrest) or cytotoxic (apoptosis) consequences. The SST analog SMS 201-995 (octreotide, OCT) inhibits of MCF-7 human breast adenocarcinoma cells, which express multiple SSTRs. Its action has been reported to result in either apoptosis arrest, but the underlying mechanisms have not elucidated this model. Here, we report that OCT elicits response these leading apoptosis, is...
Ligand-activated somatostatin receptors (SSTRs) initiate cytotoxic or cytostatic antiproliferative signals. We have previously shown that cytotoxicity leading to apoptosis was signaled solely via human (h) SSTR subtype 3, whereas the other four hSSTR subtypes initiated a response led growth inhibition. In present study we characterized signaling mediated by 1, 2, 4, and 5 in CHO-K1 cells. report here these results induction of retinoblastoma protein Rb G1 cell cycle arrest. Immunoblot...
Recruitment of the SH2 domain containing cytoplasmic protein-tyrosine phosphatase SHP-1 to membrane by somatostatin (SST) is an early event in its antiproliferative signaling that induces intracellular acidification-dependent apoptosis breast cancer cells. Fas ligation also a manner requiring presence at membrane. Moreover, we have recently reported required not only for acidification, but apoptotic events follow acidification (Thangaraju, M., Sharma, K., Liu, D., Shen, S. H., and Srikant,...
Mutations critical for the central nervous system (CNS) attenuation of Sabin vaccine strains poliovirus (PV) are located within viral internal ribosome entry site (IRES). We examined interaction IRESs PV type 3 (PV3) and (Sabin3) with polypyrimidine tract-binding protein (PTB) a neural cell-specific homologue, nPTB. PTB nPTB were found to bind directly adjacent attenuating mutation, binding at this was less efficient on Sabin3 IRES than PV3 IRES. Translation mediated by in neurons chicken...
BackgroundThe ANTHEM-HF pilot study was an open-label that evaluated the safety and feasibility of autonomic regulation therapy (ART) utilizing cervical vagus nerve stimulation (VNS) for patients with chronic HF reduced EF (HFrEF). Patients in NYHA class II-III ≤40% (n = 60) received ART 6 months post-titration. associated sustained improvement left ventricular (LV) function symptoms at 12 months.MethodsContinuously cyclic VNS maintained to determine longer-term effects ART....
In patients with coronavirus disease 2019 (COVID-19), various cutaneous symptoms have been observed. Herpes zoster (HZ) is an infectious skin caused by the varicella-zoster virus (VZV) that, after a primary chickenpox infection, persists dormant in dorsal root ganglia of nerves. Unusual prolonged dermatological from recovered COVID-19 rarely recorded. this report, we describe case HZ following recovery COVID-19.
State-of-the-art automatic atrial fibrillation (AF) detection models trained on RR-interval (RRI) features generally produce high performance standard benchmark electrocardiogram (ECG) AF datasets. These models, however, result in a significantly false positive rates (FPRs) when applied ECG data collected under free-living ambulatory conditions and the presence of non-AF arrhythmias.This paper proposes DeepAware, novel hybrid model combining deep learning (DL) context-aware heuristics (CAH),...
The study of energy consumption in buildings is crucial due to environmental and financial impacts. Smart metering suggested improve efficiency, but predicting electrical accurately remains challenging, considering various factors. To tackle this, we propose a Multi-objective Golden Eagle Optimization (MGE) based Hybrid Deep Dynamic Convolutional Fuzzy Network (HDDCFN) method. This approach optimizes algorithm parameters prediction models using multi-objective optimization, historical usage...
Drug-eluting balloons, surface-coated with antiproliferative agents such as sirolimus or paclitaxel, have emerged an alternative therapeutic option for coronary stenosis. This study evaluated safety and effectiveness of the MOZEC sirolimus-eluting percutaneous transluminal angioplasty (PTCA) balloon dilation catheter (Meril Life Sciences Pvt. Ltd., India) across diverse clinical scenarios in artery stenosis treatment. A prospective, single-arm, multicenter, real-world, post-marketing...
Therapeutic regimens for adult T-cell leukemia/lymphoma (ATL) are limited with unsatisfactory results, thereby warranting development of novel therapies. This study investigated antitumor activity and toxicity alemtuzumab regard to response, duration progression-free survival, overall survival in patients human lymphotropic virus-1 (HTLV-1)-associated ATL.Twenty-nine chronic, acute, lymphomatous types ATL were enrolled a single-institution, nonrandomized, open-label phase II trial wherein...
Introduction . The current study was designed to evaluate the association of neutrophil-to-lymphocyte ratio (NLR) with coronary artery disease (CAD) presence. We also aimed propose a suitable cut-off NLR for diagnosis CAD in Western Indians. Methods Total 324 patients undergoing angiography were enrolled and subdivided into two groups: group 1 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn...