A5054534685- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Cancer Immunotherapy and Biomarkers
- Escherichia coli research studies
- Immune Cell Function and Interaction
University of Trento
2020-2022
A growing body of evidence supports the notion that gut microbiome plays an important role in cancer immunity. However, underpinning mechanisms remain to be fully elucidated. One attractive hypothesis envisages among T cells elicited by plethora proteins a few exist incidentally recognize neo-epitopes arising from mutations ("molecular mimicry (MM)" hypothesis). To support MM, human probiotic Escherichia coli Nissle was engineered with SIINFEKL epitope (OVA-E.coli Nissle) and orally...
DHX30 was recently implicated in the translation control of mRNAs involved p53-dependent apoptosis. Here, we show that exhibits a more general function by integrating activities its cytoplasmic isoform and abundant mitochondrial one. The depletion both isoforms HCT116 cells leads to constitutive changes polysome-associated mRNAs, enhancing coding for ribosomal proteins while reducing translational efficiency nuclear-encoded mitoribosome mRNAs. Furthermore, higher global but slower...
Abstract DHX30 was recently implicated in the translation control of mRNAs involved p53-dependent apoptosis. Here we show that exhibits a more general function by integrating activities its cytoplasmic isoform and abundant mitochondrial one. The depletion both isoforms HCT116 cells leads to constitutive changes polysome-associated mRNAs, enhancing coding for ribosomal proteins while reducing translational efficiency nuclear-encoded mitoribosome mRNAs. Furthermore, higher global but slower...
Abstract The gut microbiome plays a key role in cancer immunity. One proposed mechanism is through the elicitation of T cells, which incidentally recognize neo-epitopes arising from mutations (“molecular mimicry (MM)” hypothesis). To support MM, Escherichia coli Nissle was engineered with SIINFEKL epitope (OVA) and orally administered to C57BL/6 mice. treatment elicited OVA-specific CD8 + cells lamina propria inhibited growth OVA-B16F10 tumors. Importantly, administration Outer Membrane...