A5040111111- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Organic and Inorganic Chemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Analytical Chemistry and Chromatography
- Synthesis and Biological Activity
- Chemical Synthesis and Reactions
- Marine Sponges and Natural Products
- Catalytic Alkyne Reactions
- Fluorine in Organic Chemistry
- Enzyme Catalysis and Immobilization
- Coordination Chemistry and Organometallics
- Molecular spectroscopy and chirality
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Oxidative Organic Chemistry Reactions
- Catalysis and Oxidation Reactions
- Synthesis of Organic Compounds
- Chemical synthesis and alkaloids
- Organometallic Complex Synthesis and Catalysis
- Catalysis for Biomass Conversion
- Synthesis and Reactions of Organic Compounds
University of Warsaw
2010-2025
Warsaw University of Technology
1997-2004
Institute of Organic Chemistry
1985-1996
Polish Academy of Sciences
1984-1996
National Veterinary Research Institute
1987-1995
Microbial transglutaminase (mTG) is a bacterial survival factor, which frequently used as food additive. This results in the formation of immunogenic epitopes that may cause autoimmunity. Primary biliary cholangitis (PBC) cholestatic, autoimmune liver disease characterized by presence characteristic autoantibodies. The aim this work was to determine epitope similarity and cross-reactivity between mTG- PBC-specific antigens investigate whether microbial enzyme be associated with induction...
Abstract Starting from sultam 1 , the chiral dienophile (2 R )‐ N ‐glyoxyloylbornane‐10,2‐sultam ( 4 ) was readily prepared. Non‐catalyzed atmospheric‐ and high‐pressure as well [Eu(fod) 3 ]‐promoted [4 + 2] cycloadditions of 1‐methoxy‐buta‐1,3‐diene 5 to leading with high asymmetric induction 6‐methoxy‐3,6‐dihydro‐2 H ‐pyran‐2‐yl derivatives 6 – 9 are described. The extent direction in these reactions were established by H‐NMR analysis chemical correlation, respectively. Stereochemical...
High-pressure [4+2]cycloaddition of 1-methoxybuta-1,3-diene to carbonyl compounds is described. The pressure required successfully reduced 10 kbar with the use a lanthanide catalyst.
The high-pressure cycloaddition of 2,3-O-isopropylidene-D-glyceraldehyde (7) to 1-methoxybuta-1,3-diene (1) afforded the diastereoisomeric cycloadducts (3) for which excess and absolute configuration have been determined.
The highly diastereoselective [4 + 2] cycloaddition of 1-methoxybuta-1,3-diene (3) to (2R)-N-glyoxyloylbornane-10,2-sultam (2) afforded the adduct (4) which was effectively transformed into (4R,6S)-4-hydroxy-6-hydroxymethyltetrahydro-2-pyrone (1), a key synthon for lactone moiety compactin and mevinolin.
Abstract A library of monodentate furanoside phosphoramidites, easily synthesized from inexpensive D ‐xylose and optically pure 1,1′‐bi‐2‐naphthol (BINOL), was used as ligands for the palladium‐catalyzed allylic alkylation amination. The matched pair formed ‐xylose‐derivatives ( S )‐BINOL. asymmetric induction depends strongly on substituent at C5 carbohydrate backbone; both bulky 5‐ O ‐pivaloyl 5‐deoxy derivatives gave excellent results, whereas with trityl protection position induced low...
Abstract Among seventeen different Lewis acids, TiCl 4 was found to be the best catalyst for [4 + 2] cycloaddition of cyclopentadiene N , ′‐fumaroylbis[(2 R )‐bornane‐10,2‐sultam] ((−)‐ 1 ). Independently molar concentration, almost constant and complete (98–89% d.e.) diastereofacial π‐selection achieved in Diels ‐ Alder addition (−)‐ cyclopentadiene, cyclohexadiene, isoprene, 2,3‐dimethylbuta‐1,3‐diene.