A5077622191- Sarcoma Diagnosis and Treatment
- Ecology and Vegetation Dynamics Studies
- Biological Control of Invasive Species
- Plant and animal studies
- Tumors and Oncological Cases
- Species Distribution and Climate Change
- Wildlife Ecology and Conservation
- Medical Imaging and Pathology Studies
- Forest Insect Ecology and Management
- Testicular diseases and treatments
- Soft tissue tumor case studies
- Plant Diversity and Evolution
- Cassava research and cyanide
- Lymphoma Diagnosis and Treatment
- Insect and Arachnid Ecology and Behavior
- Plant and Fungal Species Descriptions
- Botany and Plant Ecology Studies
- Histiocytic Disorders and Treatments
- Forest Ecology and Biodiversity Studies
- Genetic diversity and population structure
- Cancer Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Conservation, Biodiversity, and Resource Management
- Neuroblastoma Research and Treatments
- Renal and related cancers
The University of Western Australia
2015-2025
Commonwealth Scientific and Industrial Research Organisation
2009-2025
CSIRO Health and Biosecurity
2019-2024
CSIRO Land and Water
2015-2020
University of Cape Town
1976-2015
Groote Schuur Hospital
1976-2015
Medical Research Council
2015
Ecosystem Sciences
2011-2013
Centre d'Écologie Fonctionnelle et Évolutive
2008-2011
The University of Melbourne
2004-2009
PURPOSE: The study goal was to improve outcome in children with rhabdomyosarcoma by comparing risk-based regimens of surgery, radiotherapy (RT) and chemotherapy. PATIENTS AND METHODS: Eight hundred eighty-three previously untreated eligible patients nonmetastatic entered the Intergroup Rhabdomyosarcoma Study-IV (IRS-IV) (1991 1997) after surgery were randomized treatment primary tumor site, group (1 3), stage (I III). Failure-free survival (FFS) rates end points used comparisons between...
The results of treatment 686, previously untreated patients younger than 21 years with rhabdomyosarcoma or undifferentiated sarcoma, who were entered on Intergroup Rhabdomyosarcoma Study-I (IRS-I) analyzed after a minimum potential follow-up time 7 years. Patients in Clinical Group I (localized disease, completely resected) randomized to receive either vincristine, dactinomycin, and cyclophosphamide (VAC) VAC + radiation. At 5 years, approximately 80% given still disease-free there was no...
Background. Intergroup Rhabdomyosarcoma Study (IRS)-II, (1978–1984) had the general goals of improving survival and treatment children with rhabdomyosarcoma (RMS). Methods. Nine hundred ninety-nine previously untreated eligible patients entered study after surgery were randomized or assigned to therapy by IRS Clinical Group (I-IV), tumor site, histologic type. Outcomes compared between treatments results IRS-I (1972–1978). Results. Patients in I, excluding extremity alveolar (EA) RMS,...
Summary 1. Gridded climatologies have become an indispensable component of bioclimatic modelling, with a range applications spanning conservation and pest management. Such globally conformal data sets historical future scenario climate surfaces are required to model species potential ranges under current scenarios. 2. We developed set interpolated at 10′ 30′ resolution for global land areas excluding Antarctica. Input the baseline climatology were gathered from WorldClim CRU CL1·0 CL2·0...
Background. There is a need to develop single prognostically significant classification of rhabdomyosarcomas (RMS) and other related tumors children, adolescents, young adults which would be current guide for their diagnosis, allow valid comparison outcomes between protocols carried out anywhere in the world, should enhance recognition prognostic subsets. Method. Sixteen pathologists from eight pathology groups, representing six countries several cooperative classified by four...
A specific chromosomal abnormality, t(2;13)(q35;q14), was discovered in five cases of advanced rhabdomyosarcoma. It identified directly cells that had metastasized from bone marrow one patient and xenografts derived the tumors four other patients. The translocation not restricted by histologic subtype, but found classified as alveolar, undifferentiated, or embryonal. Cytogenetic hallmarks gene amplification (double minute chromosomes homogeneously staining regions) were apparent three cases....
Abstract Aim Investigate the relative abilities of different bioclimatic models and data sets to project species ranges in novel environments utilizing natural experiment biogeography provided by Australian Acacia species. Location Australia, South Africa. Methods We built for cyclops pycnantha using two discriminatory correlative (M ax E nt Boosted Regression Trees) a mechanistic niche model (CLIMEX). fitted training sets: native‐range only (‘restricted’) all available global excluding...
Abstract Aim Correlative species distribution models ( SDM s) often involve some degree of projection into novel covariate space (i.e. extrapolation), because calibration data may not encompass the entire interest. Most methods for identifying extrapolation focus on range each model individually. However, can occur that is well within univariate variation, but which exhibits combinations between covariates. Our objective was to develop a tool detect, distinguish and quantify these two types...
Scientists have recognized the potential for applying gene drive technologies to control of invasive species several years (1, 2), yet debate about application has been primarily restricted mosquitoes (3). Recent developments in clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology restarted discussions using (4).
Prestudy patient characteristics and specific therapy of all eligible patients with rhabdomyosarcoma entered into Intergroup Rhabdomyosarcoma (RMS) Studies I (IRS-I) (1972 to 1978, n = 686) or II (IRS-II) (1978 1984, 1,002) were examined for their relationship survival within each the four clinical groups using univariate multivariate analyses. The estimated at 5 years from start treatment was 56% in IRS-I 62% IRS-II (P .006). largest difference between studies group III tumors (52% v 65%)....
PURPOSE One hundred thirty of 2,792 patients (5%) registered on three Intergroup Rhabdomyosarcoma Study clinical trials (IRS-I, -II, and -III) from 1972 to 1991 had an extraosseous Ewing's sarcoma (EOE). We report here the results multimodality therapy for this tumor. PATIENTS AND METHODS The 130 were less than 21 years age; 70 (54%) males. Primary tumor sites trunk in 41 patients, extremity 34, head/neck 23, retroperitoneum/pelvis 21, other 11. fourteen no metastases at diagnosis. In was...
Abstract Global change is driving a massive rearrangement of the world's biota. Trajectories distributional shifts are shaped by species traits, recipient environment and forces with many directly due to human activities. The relative importance each in determining distributions introduced poorly understood. We consider 11 Australian Acacia South Africa for different reasons (commercial forestry, dune stabilization ornamentation) determine how features introduction pathway have their...
Abstract Logged and disturbed forests are often viewed as degraded depauperate environments compared with primary forest. However, they dynamic ecosystems 1 that provide refugia for large amounts of biodiversity 2,3 , so we cannot afford to underestimate their conservation value 4 . Here present empirically defined thresholds categorizing the logged forests, using one most comprehensive assessments taxon responses habitat degradation in any tropical forest environment. We analysed impact...
The authors assessed a panel of immunohistochemical stains against 109 pediatric solid tumors, primarily rhabdomyosarcomas, under the auspices Intergroup Rhabdomyosarcoma Study. Fresh tumor tissue received from participating organizations was divided into portions that were either frozen or fixed in formalin, alcohol, B5. Immunostaining performed by avidin-biotin complex method using monoclonal antibodies to desmin, neurofilaments, vimentin, cytokeratin, and leukocyte common antigen on...
ABSTRACT The ability to ascribe native or alien status species in a rapidly changing world underpins diverse research fields that overlap with global change and biological invasions via biodiversity. Current definitions generally link anthropogenic dispersal events, but this can create conflicts for active management adaptation strategies, such as managed relocation restoration ecology. Here we propose unifying approach allows the incorporation of rapid into invasion terminology. We...
Abstract Aim To explore whether the subspecific genetic entities of Acacia saligna occupy different bioclimatic niches in their native and introduced ranges these are predictable using species distribution models (SDMs). Location Australia, South Africa Mediterranean Basin. Methods Species were developed MAXENT six climatic variables to calculate suitability A. . We assessed (1) niche differences identified by SDMs measures overlap model performance; (2) ability predict most likely present...