A5070599989- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Berberine and alkaloids research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
Columbia University
2020-2021
Mitragynine (MG) is the most abundant alkaloid component of psychoactive plant material "kratom", which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disorders. We have developed a synthetic method selective functionalization unexplored C11 position MG scaffold (C6 indole numbering) via an indole-ethylene glycol adduct subsequent iridium-catalyzed borylation. Through this work we discover that represents...
<p>Mitragynine is the most abundant alkaloid component of psychoactive plant material “kratom”, which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disorders. We developed a new synthetic method selective functionalization unexplored C11 position mitragynine scaffold (C6 indole numbering) via an indole-ethylene glycol adduct subsequent iridium-catalyzed borylation. discovered that represents key...
Mitragynine is the most abundant alkaloid component of psychoactive plant material “kratom”, which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disorders. We developed a new synthetic method selective functionalization unexplored C11 position mitragynine scaffold (C6 indole numbering) via an indole-ethylene glycol adduct subsequent iridium-catalyzed borylation. discovered that represents key locant...