A5068518163- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
- Synthesis and Catalytic Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Microwave-Assisted Synthesis and Applications
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Mechanisms and Therapy
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Mycobacterium research and diagnosis
- Click Chemistry and Applications
- Synthesis and Characterization of Pyrroles
- Fluorine in Organic Chemistry
- Organic Chemistry Synthesis Methods
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Synthesis and biological activity
Universidade Federal de Santa Maria
2013-2021
This study reports a comparison between conventional methods, ionic liquids, microwave (MW) irradiation, and combinations thereof for the synthesis of series fourteen 1-aryl-2-arylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines. In all reactions tested, products were obtained at very good yields (87–97%), but reaction times different, depending on method used. Comparing to other time decreased 1 min when [BMIM]BF4 under MW irradiation was used, thus evidencing synergic effect.
The synthetic versatility of 4-alkoxy-4-alkyl/aryl-1,1,1-trichloroalk-3-en-2-ones (enones) for the synthesis [1,2,4]triazolo[1,5-a]pyrimidines, in which trichloromethyl group is either maintained or eliminated from product by simply controlling reaction medium, reported. These enones react with 3-amino-1H-1,2,4-triazoles under acidic conditions to furnish exclusively 7-(trichloromethyl)-[1,2,4]triazolo[1,5-a]pyrimidines, whereas basic [1,2,4]triazolo[1,5-a]pyrimidin-5/7(1H)-ones are obtained...
The reaction of pyrazoles with 5-bromo enones furnished an unexpected series stable<italic>N</italic>,<italic>O</italic>-aminals in a chemo- and regioselective metal free reaction.
5-Bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one was used as an efficient precursor for the synthesis of a new series (1,2,3-triazol-1-yl)methyl-pyrimidine biheterocycles. For this stepwise synthesis, 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one first converted into 5-azido-1,1,1-trifluoro-4-methoxypent-3-en-2-one through nucleophilic substitution bromine by azide group. This then followed azide–alkyne cycloaddition reaction (click chemistry) to give key intermediate...
Abstract This study reports the chemo‐ and regioselective synthesis, at good yields, of ( E )‐4‐(amino)‐1,1,1‐trifluoro‐5‐(4,5‐alkyl‐3‐(trifluoromethyl)‐1 H ‐pyrazol‐1‐yl)pent‐3‐en‐2‐ones (pyrazole‐enaminones), from N ‐alkylation reaction trifluoromethyl pyrazoles with 5‐bromo enaminones. The obtained compounds were tested as potential analgesics in a screening test involving mice. Three these significantly reduced spontaneous nociception induced by application capsaicin, which is an...
This study reports a simple and highly regioselective synthesis of new series 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3<i>H</i>)-ones, in which the 6-substituents are methyl or aryl groups 3-substituents alkyl, allyl, phenyl, benzyl, 2-phenylethyl groups. The products obtained good yields by cyclocondensation appropriate 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with nonsymmetric 1-substituted 2-methylisothiourea sulfates under mild basic conditions.
This study reports a simple, fast, and efficient method for the synthesis of new series 1-arylethyl-2-arylethylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines related compounds from reaction 2-alkoxy-5-trifluoroacetyl-3,4-dihydro-2H-pyrans with 2-arylethanamines 2-ethanamines. The desired tetrahydropyridines were obtained in excellent yields (90–98%), through that can be described as an AAB′ three-component protocol following ANRORC-type mechanism.
Abstract The title pyrimidinones are highly regioselectively obtained by cyclocondensation of trichloro‐alkenones with non‐symmetric substituted isothiourea sulfates under mild basic conditions.
The analgesic action of pyrazoles is widely studied and among the commercially available drugs containing pyrazoline nucleus can be highlighted dipyrone Celecoxib. Celecoxib (CelebrexTM) a non-steroidal anti-inflammatory used in treatment diseases such as rheumatoid arthritis. It was first selective inhibitor cyclooxygenase 2 (COX-2) launched world, however, there are several questions about their toxicity, especially with regard to cardiovascular system.Some methodologies for synthesis have...