A5062484965- Chemokine receptors and signaling
- Immune cells in cancer
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- interferon and immune responses
- Herpesvirus Infections and Treatments
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Ocular Surface and Contact Lens
- Immune responses and vaccinations
University of Glasgow
2017-2024
Institute of Infection and Immunity
2022
Highlights•Mice deficient in CCR1, CCR2, CCR3, and CCR5 (iCCRs) develop normally•iCCRs redundantly establish resting tissue-resident myelomonocytic cell populations•CCR2 dominates controlling monocyte recruitment acute inflammation•iCCRs are not involved neutrophil or lymphocyte inflammationSummaryCurrently, we lack an understanding of the individual combinatorial roles for chemokine receptors inflammatory process. We report studies on mice with a compound deletion Ccr1, Ccr2, Ccr3, Ccr5,...
Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity this system, coupled with lack appropriate in vivo models, has limited our understanding how orchestrate inflammatory responses hampered attempts at targeting system disease. Novel approaches therefore needed provide crucial biological, therapeutic, insights into chemokine-chemokine receptor family. Here, we report generation transgenic multi-chemokine...
Abstract CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites plays prominent roles in inflammatory pathologies cancer. It has therefore been highlighted as important therapeutic target. However the success targeting threatened by our relative lack knowledge its precise vivo mode action. Here we demonstrate that CXCR2-deficient mice display a counterintuitive transient exaggerated response cutaneous peritoneal stimuli. In both situations, this associated...
Abstract Chemokines regulate leukocyte navigation to inflamed sites and specific tissue locales may therefore be useful for ensuring accurate homing of cell therapeutic products. We, others, have shown that atypical chemokine receptor 2 (ACKR2)-deficient mice (ACKR2−/−) are protected from metastasis development in line spontaneous mouse models. We this relates enhanced CCR2 expression on ACKR2−/− natural killer cells, allowing them home more effectively ligand-expressing metastatic deposits....
Abstract Chemokines are members of a large family chemotactic cytokines that signal through their receptors to mediate leukocyte recruitment during inflammation and homeostasis. The chemokine receptor CXCR2 has largely been associated with neutrophil recruitment. However, there is emerging evidence roles for chemokines in processes other than migration. We have previously demonstrated knockout (KO) mice thinner skin compared wild-type mice. Herein we demonstrate this due subcutaneous adipose...
Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), common pathogen infecting most of the world’s population. Inflammation in HSK chemokine-dependent, particularly CXCL10 and less so CC chemokines. The atypical chemokine receptor-2 (ACKR2) decoy receptor predominantly for pro-inflammatory chemokines, which regulates inflammatory response scavenging chemokines thereby modulating leukocyte infiltration. Deletion ACKR2 exacerbates delays...
Summary Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity this system, coupled with lack appropriate in vivo models, has limited our understanding how orchestrate inflammatory responses hampered attempts at targeting system disease. Novel approaches therefore needed provide crucial biological, therapeutic, insights into chemokine-chemokine receptor family. Here, we report generation transgenic...
Abstract Chemokines are members of a large family chemotactic cytokines that signal through their receptors to mediate leukocyte recruitment during inflammation and homeostasis. The chemokine receptor CXCR2 has largely been associated with neutrophil recruitment. However, there is emerging evidence roles for chemokines in processes other than migration. We have previously demonstrated KO mice thinner skin compared wild type mice. Herein we demonstrate this due subcutaneous adipose layer, as...