<b>Objective </b>To assess the acceptability of pre-pandemic influenza vaccination among healthcare workers in public hospitals Hong Kong and effect escalation World Health Organization’s alert level for an pandemic. <b>Design </b>Repeated cross sectional studies using self administered, anonymous questionnaires <b>Setting </b>Surveys at 31 hospital departments internal medicine, paediatrics, emergency medicine under Hospital Authority from January to March 2009 May <b>Participants </b>2255...

We report on the concentration ranges and combustion source-related emission profiles of organic inorganic species released during 34 major industrial fires in UK. These episodic events tend to be acute nature demand a rapid public health risk assessment indicate likely impact exposed populations. The objective this paper is improve our understanding nature, composition potential impacts emissions from incident so support process. Real world monitoring data was obtained portable Fourier...

The 2007 UK National Radiotherapy Advisory Group report indicated that the number and type of staff available is one "rate-limiting" steps in improving productivity radiotherapy departments. Retaining well-trained, satisfied key to meeting objectives report; burnout an important factor linked satisfaction attrition. results a survey measuring sample radiotherapists (therapy radiographers) are presented considered against norms for health sector therapists from Canada USA. Case study...

Public exposure to significantly elevated levels of particulate matter (PM) as a result major fires at industrial sites is worldwide problem. Our paper describes how the United Kingdom developed its Air Quality in Major Incidents (AQinMI) service provide fire emission plume concentration data for use by managers time incident and allow an informed public health response. It one first civilian services type anywhere world. Based on involvement several authors AQinMI service, we describe...

Industrial fires at facilities including waste management sites, warehouses, factories, chemical works, and fuel storage depots are relatively frequent occurrences. Often, these occur adjacent to urban communities result in ground-level airborne pollutant concentrations that well above guideline values. Land, water, livestock, crops may also be contaminated by the emissions firefighting activities. Moreover, impacted tend have a higher proportion of minority ethnic populations as individuals...

We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that mature cells and myeloid to alpha-particles from plutonium-238 X radiation. All three populations are relatively sensitive, but ultrasensitive. This differential is also observed corticosteroid, etoposide, cisplatin, all apoptosis-inducing drugs used in treatment leukemia other cancers. Further, we show x-rays induce bulk precursor population undergo rapid apoptosis, despite...

Episodic air pollution events that occur because of wildfires, dust storms and industrial incidents can expose populations to particulate matter (PM) concentrations in the thousands µg m-3. Such have increased frequency duration over recent years, with this trend predicted continue short medium term climate warming. The human health cost episodic PM be significant, inflammatory responses are measurable even after only a few hours exposure. Consequently, advice for protection public should...

To resolve the controversy concerning role of p53 in killing resting lymphocytes by purine nucleoside analogues, we examined cytotoxic effects chlorodeoxyadenosine, fludarabine and deoxycoformycin (plus deoxyadenosine) on unstimulated spleen cells from p53‐knockout versus wild‐type mice. were more resistant to all three nucleosides than cells. However, substantial still occurred absence p53, indicating that analogues can kill both p53‐dependent ‐independent mechanisms. We suggest these...

Industrial fires at facilities including waste management sites, warehouses, factories, chemical works and fuel storage depots are relatively frequent occurrences. Often, these occur adjacent to urban communities result in ground-level airborne pollutant concentrations that well above guideline values. Land, water, livestock crops may also be contaminated by the emissions firefighting activities. Moreover, impacted tend have a higher proportion of minority ethnic populations, individuals...

In January 2009 David Cameron announced that the ‘underlying philosophy’ of his government would be progressive conservatism. Despite ambiguity about this term, it was generally interpreted as a signal moving party to left. To some commentators, allying with ‘one nation’ strand conservative thought. others, particularly in media, he drawing on more immediate influence Phillip Blond's ‘Red Toryism’. However, focus market (as opposed state or community) found both Cameron's speech and...

AbstractB lymphocyte precursor cells are the target for major subtype of paediatric cancer, acute lymphoblastic leukaemia. Using a murine IL-7-dependent clonogenic assay normal B cell precursors as model, we have investigated sensitivity these versus other and leukaemic haemopoietic to α-particle radiation. We find that remarkably susceptible lethal effects α-particles very low probability surviving single α-track. also sensitive LET X-rays. The mutation frequency in marker gene (HPRT) does...

‘Statecraft’ theory, with its focus on politicians' strategic, electoral choices, has undergone a revival in recent years. This is reply to those authors who have used their analysis of the Conservative Party under David Cameron [notably Hayton (2014),Parliamentary Affairs 67, 1; Gamble (2014)Parliamentary Affairs]. Statecraft theory raises various questions and contains implications—ontological, epistemic methodological—that need be dealt by contemporary advocates. I conclude that while...

In this paper, we explore the role played by apoptosis in genesis of cancer. The hypothesis under test is that affords a means whereby cells have sustained genotoxic damage can be irreversibly deleted from generative compartment affected tissue. Such damaged might otherwise acquired serious but survivable DNA modifications, and so could become precursors malignant clones (Fig. 1). One testing to devise systems which critical gene on signaling pathway selectively disabled. Following exposure...

Abstract Public services—in the UK and elsewhere—are under considerable pressure, not just from austerity, but also a variety of social, demographic technological changes (in effect ‘austerity plus’). In this context, three broad options are open to policy‐makers: continue with tried‐and‐tested approaches while spending less money, which in means reliance on ‘New Management’ ( NPM ); withdraw completely certain public services; or develop new administration. We argue that all these have been...

Simon Griffiths reviews a year of public services under the Coalition and tries to square radical programme reforms with pre‐election notion Cameron as ‘One Nation’ Conservative. If Labour is effectively challenge Coalition's anti‐state arguments, he says, it needs find compelling narrative about role place state in their provision.