Tocilizumab (TCZ; interleukine-6 receptor antagonist) has been proposed to treat severe forms of Coronavirus disease-19 (COVID-19) because plays an important role in COVID-19-induced cytokine storm. Several clinical studies have shown very good effects TCZ patients with COVID-19, a few minor side reported. Only eight serious liver injuries caused by were reported before being used the treatment COVID-19. Considering significantly increased use for we would like warn its rare but possible...

Abstract The relationship between diabetes mellitus (DM) and pancreatic cancer is complex—DM both a risk factor early sign of cancer. DM for because it increases insulin resistance, intrapancreatic concentrations insulin, the bioavailability IGF, subsequently promoting ductal cell proliferation. Accordingly, treatment targeting insulin/IGF pathway focus many researchers. Antidiabetic drugs modify cancer—metformin's antineoplastic effect being most notable indicating potential clinical use in...

Aspergillosis is a frequent invasive fungal infection in liver recipients (affecting 1%-9.2% of all patients), second only to candidiasis. Significant risk factors for aspergillosis include corticosteroid therapy, neutropenia, T-cell dysfunction, renal failure and requirement replacement therapy. Aspergillus usually affects the lungs recipients, with hematogenous dissemination occurring 50%-60% cases. Renal involvement rare considered occur 0.4% cases aspergillosis.This paper describes case...

To present a case of relapsing and resistant Sweet's syndrome that developed during pregnancy together with an onset Crohn's disease, showing complete resolution the use infliximab.A 30-year-old pregnant woman presented fever, skin lesions, diarrhea. Skin biopsy confirmed neutrophilic dermatosis she was diagnosed disease after endoscopy. There no recurrence outside her pregnancy. During previous pregnancy, while corticosteroids were ineffective, regression lesions achieved using...

We report the case of a 41-year-old man on conservative treatment for more than 20 years chronic renal insufficiency, hepatitis and recurrent cholangitis. Following lengthy extensive diagnostics, differential diagnosis included primary sclerosing cholangitis Caroli's disease (CD). To solve diagnostic challenge, next generation sequencing (NGS) was performed to distinguish between disorders possibly present in patient. The CD became evident after two rare known pathogenic mutations were...

Mediastinal ectopic thyroid tissue (ETT) is rare entity, accounting for 1% of all mediastinal tumours. A 53-year-old lady, presented with cough and atypical chest pain. computed tomography (CT) scan showed a 95 mm × 75 115 tumour mass; CT guided biopsy mass ETT. Thyroid scintigraphy Technetium-99m (99mTc) pertechnetate homogenous intense uptake in the gland (TG) lodge mediastinum. Primary hyperparathyroidism (PHPT) was diagnosed during laboratory evaluation. sestamibi (99mTc-MIBI)...

Colorectal cancer (CRC) is one of the most common malignancies worldwide. The aim this study was to compare outcomes two different screening approaches in a small country (Montenegro, 650,000 inhabitants) with CRC incidence lower than European average.Two structured invitation programs were compared respect compliance and neoplasia yield: (i) program A focused on first-degree relatives patients diagnosed hospitals (n=206), inviting them for colonoscopy; (ii) B an fecal occult blood testing,...

A high risk of bleeding in Helicobacter pylori (H. pylori)-negative, non-steroidal anti-inflammatory drugs (NSAID)-negative ulcers highlights the clinical importance analysis changing trends peptic ulcer disease. The aim study was to investigate factors for patients with non-H. infection, and no NSAIDs use.A prospective included endoscopically diagnosed were without H. infection (verified by pathohistology serology) exposure proton pump inhibitors (PPI) within 4 weeks before endoscopy. After...

Objective Liver cancer is the third most common cause of cancer-related deaths worldwide. Hepatitis B and C infections are main factors affecting mortality. During recent years, Montenegro conducted activities on eradication viral hepatitis according to global strategy for primary prevention liver The objective this study was assess mortality trend in period 1990–2018 using regression techniques. Methods data from 1990 2018 were collected. Mortality rates age standardized World Standard...

Introduction: Gastric cancer (GC) remains a significant global public health problem, despite the decreasing trends in GC mortality rates last 5 decades. Our study aimed to examine pattern of Montenegro between 1990 and 2018 contribute future by designing national long-term strategy for control prevention GC. Methods: data from were collected. Mortality age-standardized World Standard Population estimating both overall gender-specific trends. The joinpoint regression model was used assess...

Aims Although the incidence of nonvariceal upper gastrointestinal bleeding (NVUGIB) has been decreasing, mortality rate is still significant and accounts up to 10% cases. The increasing importance in pathogenesis GI use ulcerogenic medications. study was aimed asses frequency adverse events (AE) their association with individual groups drugs (nonsteroidal anti-inflammatory – NSAIDs, acetylsalicylic acid ASA, oral anticoagulants OAC, new NOAC, antiplatelet APD, corticosteroids CS, selective...

Abstract Background Oesophageal cancer (OC) is a significant public health issue, despite the decreasing trends in OC mortality rates observed globally past decades. The objective of our study to analyze pattern Montenegro between 1990 and 2018 contribute development national long-term strategy for prevention control this malignancy. Methods data on death cases were collected. standardized according World Standard Population. Joinpoint, Linear Poisson regressions applied trend. Results...

Colorectal cancer (CRC) is the second leading cause of cancer-related death in Europe. This study aimed to investigate CRC mortality trends Montenegro from 1990 2018 and critically review impact preventive activities on suppression this country. We used national data categorized by sex age. Mortality rates were age-standardized according World Standard Population. The described using regression techniques. In period 2018, there was a significant increase (P < .05). number deaths constantly...

&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To present a case of colopathy related to the use diclofenac in patient with positive immunochemical faecal occult blood test (iFOBT) and discuss influence nonsteroidal anti-inflammatory drugs (NSAIDs) on iFOBT specificity. &lt;b&gt;&lt;i&gt;Clinical Presentation Intervention:&lt;/i&gt;&lt;/b&gt; A colonoscopy 56-year-old female presenting revealed diaphragm-like strictures ulcers right colon. While carrying out detailed retrospective...

Despite the extensive use of nonsteroid anti-inflammatory drugs (NSAIDs) in general population, NSAID colopathy is very scarcely reported literature and underestimated. The slow-release enteric-coated preparations allows more to reach colon. But, how often do we think that NSAIDs may be cause a positive immunochemical faecal occult blood test (iFOBT)? iFOBT hold considerable promise over traditional guaiac methods considering improvement clinical sensitivity for colorectal cancer (CRC),...

Introduction. Nonsteroidal anti-inflammatory drug-induced colopathy is an uncommon condition associated with the long-term use of enteric-coated and slow-release nonsteroidal drugs. This paper presents a case showing no symptoms or signs, discovered by positive immunochemical faecal occult blood test. Case report. Performed within framework National Program for Screening Colorectal Cancer, test was in 56-year-old female patient. The colonoscopy revealed three lesions right colon: one...

Throughout its duration, the coronavirus disease 2019 (COVID-19) pandemic has been affecting lives worldwide and had a sizeable impact on mental health, particularly for those who already suffer from chronic illnesses. Depression, Anxiety Stress (DAS) are common psychiatric comorbidities in inflammatory bowel (IBD) patients. This study aims to determine prevalence risk factors moderate severe symptoms of DAS IBD patients have undergoing intravenous biological therapy (IvBTh) during COVID-19...

Depression is one of the most commonly occurring psychiatric comorbidities in patients suffering from inflammatory bowel disease (IBD). This study aims to determine prevalence and risk factors for more severe symptoms depression (DP) IBD on intravenous biological therapy (IBT).The consisted 90 who completed a Patient Health Questionnaire-9 (PHQ9) detect depression. Demographic information characteristics were collected as well medication these patients. Univariate multivariate ordinal...

Complications of Meckels diverticulum (MD) are rare and occur in about 4-6% cases, more frequently younger men. Most common complication is bleeding; less frequent intussusception, perforation intestinal obstruction. Detection MD its complications can be challenging, but the combination video capsule endoscopy (VCE) double - balloon (DBE) allow precise diagnosis present a challenge for clinicians. We described two patients with complicated MD: one perforated after enteroscopy, bleeding. Both...

Introduction. Gastrointestinal duplications are rare congenital anomalies, especially in the adult population which can occur along entire gastrointestinal tract. The rarest among them gastric duplications, making up 2–8% of all duplications. Unusual embryonic malformations be found even and should always considered differential diagnosis thoraco-abdominal tumors. Unclear findings during preoperative diagnostic procedures reason for presenting case. Case report. We present a 33 years old...