Sean T. Murphy

ORCID: 0000-0001-5977-7840
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About
Contact & Profiles
Research Areas
  • Insect-Plant Interactions and Control
  • Biological Control of Invasive Species
  • Ethics in medical practice
  • Insect Pest Control Strategies
  • Palliative Care and End-of-Life Issues
  • Insect behavior and control techniques
  • Forest Insect Ecology and Management
  • Insect Resistance and Genetics
  • Patient Dignity and Privacy
  • PI3K/AKT/mTOR signaling in cancer
  • American Constitutional Law and Politics
  • Plant and animal studies
  • Cassava research and cyanide
  • Torture, Ethics, and Law
  • Medical Malpractice and Liability Issues
  • Insect and Pesticide Research
  • Reproductive Health and Contraception
  • Homicide, Infanticide, and Child Abuse
  • Crystallization and Solubility Studies
  • Plant Parasitism and Resistance
  • X-ray Diffraction in Crystallography
  • Photochemistry and Electron Transfer Studies
  • Legal Systems and Judicial Processes
  • Ethics and Legal Issues in Pediatric Healthcare
  • Mosquito-borne diseases and control

CAB International
2013-2024

Providence College
2023

Covance (United Kingdom)
2021

Takeda (United States)
2012-2021

University of Exeter
2018

2iC (United Kingdom)
2018

Pfizer (United States)
2007-2015

University College Dublin
2015

Fordham University
2014

University of California, Los Angeles
1999-2009

Fall armyworm, Spodopterafrugiperda , is a crop pest native to the Americas, which has invaded and spread throughout sub-Saharan Africa within two years. Recent estimates of 20–50% maize yield loss in suggest severe impact on livelihoods. armyworm still infilling its potential range could other continents. In order understand fall armyworm’s year-round, global, distribution, we used evidence effects temperature precipitation life-history, combined with data African distributions construct...

10.3897/neobiota.40.28165 article EN cc-by NeoBiota 2018-11-09

The BIOCAT database of introductions insect biological control agents for the pests was updated to end 2010 include 6158 introductions, using 2384 different against 588 pest species in 148 countries. Of 2007 (32.6 %) led establishment, and 620 (10.1 resulted satisfactory being reported 172 (29.3 species. number has decreased each decade since 1970s, but same period a higher proportion became established contributed successful target pests, countries implementing classical increased. These...

10.1007/s10526-016-9726-3 article EN cc-by BioControl 2016-02-26

In developing countries, invasive alien species (IAS) threaten smallholder farmer production and the food security of subsistence growers, but economic impacts are widely under-reported. Here, IAS that mixed maize farming in eastern Africa presented. Maize is important for most smallholders commonly grown with horticultural crops other cereals which collectively provide nutrition income. These also national economies. Estimates five major IAS: Chilo partellus, Lethal Necrosis Disease,...

10.1016/j.gfs.2017.01.011 article EN cc-by-nc-nd Global Food Security 2017-02-21

BACKGROUND:: In response to the evolving nature of potential disasters, both human made and natural, this research identifies predictors individual emergency preparedness compliance with government requests. METHODS:: A survey a nationally representative sample US adults (1629 respondents) revealed which supplies plans they had in place; their perceived level that local health care system; likelihood 7 terrorist 4 naturally occurring events, whether would evacuate home; shelter place at home...

10.1097/dmp.0b013e3181a9c6c5 article EN Disaster Medicine and Public Health Preparedness 2009-07-07

Vegetation community composition and the above- below-ground invertebrate communities are linked intrinsically, though few studies have assessed impact of non-native plants on both these parts together. We evaluated differences in (foliage- ground-dwelling) nine uninvaded plots invaded by annual invasive species Impatiens glandulifera, UK during 2007 2008. Over 139,000 invertebrates were identified into distinct taxa categorised functional feeding groups. The I. glandulifera vegetation was...

10.1371/journal.pone.0067271 article EN cc-by PLoS ONE 2013-06-28

Abstract As part of a census the Indian rhinoceros Rhinoceros unicornis survey was conducted to measure extent invasion by neotropical plant mikania Mikania micrantha across major habitats Chitwan National Park important for conservation rhinoceros. Previous work has demonstrated that this fire-adapted can smother and kill native flora such as grasses sapling trees, several which are fodder plants Here, additional studies were on risks anthropogenic factors (natural resource collection...

10.1017/s003060531200124x article EN Oryx 2013-07-01

Liriomyza huidobrensis (Blanchard) is native to South America but has expanded its range and invaded many regions of the world, primarily on flowers a lesser extent horticultural product shipments. As result initial invasion into an area, damage caused usually significant not necessarily sustained. Currently, it economic pest in selected world. Adults cause by puncturing abaxial adaxial leaf surfaces for feeding egg laying sites. Larvae mine parenchyma tissues which can lead leaves drying...

10.1093/jisesa/iew121 article EN cc-by-nc-nd Journal of Insect Science 2016-12-08

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyanine Borate Salts that Form Penetrated Ion Pairs in Benzene Solution: Synthesis, Properties, and StructureSean Murphy, Xiquiang Yang, Gary B. SchusterCite this: J. Org. Chem. 1995, 60, 8, 2411–2422Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/jo00113a022https://doi.org/10.1021/jo00113a022research-articleACS PublicationsRequest reuse...

10.1021/jo00113a022 article EN The Journal of Organic Chemistry 1995-04-01

Parkinson's disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies fewer side effects. GPR6 an orphan G-protein coupled receptor (GPCR) highly restricted expression in dopamine D2-type medium spiny neurons (MSNs) of indirect pathway, striatal brain circuit which shows aberrant hyperactivity PD patients. Potent selective inverse agonists (IAG) were developed starting from low-potency screening hit (EC50 = 43 μM). Herein, we...

10.1021/acs.jmedchem.0c02081 article EN Journal of Medicinal Chemistry 2021-04-16

The ground state (S0) and lowest energy triplet (T1) surfaces of the parent dioxetane have been extensively explored using various CASSCF active spaces with MP2 corrections in several basis sets. In particular, singlet/triplet surface crossing regions examined spin−orbit coupling energetics computed. computed barrier for ring-opening is 16 kcal mol-1, which lower than experimentally observed threshold (22 mol-1) unsubstituted decomposition. However, topology good agreement experimental...

10.1021/jp9848086 article EN The Journal of Physical Chemistry A 1999-02-25

Cell cycle checkpoint intervention is an effective therapeutic strategy for cancer when applied to patients predisposed respond and the treatment well-tolerated. A critical cell process that could be targeted mitotic (spindle assembly checkpoint) which governs metaphase-to-anaphase transition insures proper chromosomal segregation. The kinase Mps1 was selected explore whether enhancement in genomic instability a viable strategy. basal-a subset of triple-negative breast chosen as model system...

10.1371/journal.pone.0138616 article EN cc-by PLoS ONE 2015-09-23

GPR6 is an orphan G-protein–coupled receptor that has enriched expression in the striatopallidal, indirect pathway and medium spiny neurons of striatum. This greatly impacted by loss nigro-striatal dopaminergic Parkinson disease, modulating this neurocircuitry can be therapeutically beneficial. In study, we describe vitro vivo pharmacological characterization (R)-1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-((tetrahydrofuran-3-yl)amino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one...

10.1124/jpet.120.000438 article EN Journal of Pharmacology and Experimental Therapeutics 2021-04-01

Abstract Smallholder farmers are the mainstay of agricultural economies sub-Saharan Africa (SSA), where they produce several crops, predominantly centered on maize. productivity remains limited resulting from a range confounding factors, but primary cause is loss pests and diseases, particularly insects. To improve productivity, recommendations for mitigation crop globally include early-warning management systems in-season indigenous pests. There many in temperate regions; however, such...

10.1093/jipm/pmad026 article EN cc-by Journal of Integrated Pest Management 2024-01-01

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPenetrated ion pairs: photochemistry of cyanine dyes within organic boratesXiqiang Yang, Alexei Zaitsev, Bjorn Sauerwein, Sean Murphy, and Gary B. SchusterCite this: J. Am. Chem. Soc. 1992, 114, 2, 793–794Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ja00028a075https://doi.org/10.1021/ja00028a075research-articleACS PublicationsRequest reuse...

10.1021/ja00028a075 article EN Journal of the American Chemical Society 1992-01-01
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