A5067079731- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Phytochemicals and Antioxidant Activities
- bioluminescence and chemiluminescence research
- Adenosine and Purinergic Signaling
- Free Radicals and Antioxidants
- Amino Acid Enzymes and Metabolism
- Sirtuins and Resveratrol in Medicine
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Protein Kinase Regulation and GTPase Signaling
- Mitochondrial Function and Pathology
- Melanoma and MAPK Pathways
University of Georgia
2022-2024
University of Liverpool
2024
In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications, including phosphorylation Ser/Thr residues and oxidation cysteine (Cys) residues. While regulation activation segment well understood, relatively little known about how modulate catalysis. this study, we investigate redox the AMPK-related brain-selective kinases (BRSK) 1 2, detail broad catalytic activity directly through reversible reduction evolutionarily conserved Cys within...
In eukaryotes, protein kinase signaling is regulated by a diverse array of post- translational modifications (PTMs). While regulation activation segment phosphorylation in Ser/Thr kinases well understood, relatively little known about how oxidation cysteine (Cys) amino acids modulate catalysis. this study, we investigate redox the AMPK-related Brain-selective (BRSK) 1 and 2, detail broad catalytic activity directly through reversible reduction evolutionarily conserved Cys residues within...
In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications, including phosphorylation Ser/Thr residues and oxidation cysteine (Cys) residues. While regulation activation segment well understood, relatively little known about how modulate catalysis. this study, we investigate redox the AMPK-related brain-selective kinases (BRSK) 1 2, detail broad catalytic activity directly through reversible reduction evolutionarily conserved Cys within...
ABSTRACT The Protein Kinase Ontology (ProKinO) is an integrated knowledge graph that conceptualizes the complex relationships connecting protein kinase sequence, structure, function, and disease in a human machine-readable format. Here we extend scope of ProKinO as discovery tool by including new classes capturing information on ligand binding sites, expression patterns, functional features, demonstrate its application uncovering regarding understudied members family. Specifically, through...
Abstract In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications (PTMs), including phosphorylation Ser/Thr residues and oxidation cysteine (Cys) residues. While regulation activation segment well understood, relatively little known about how modulate catalysis. this study, we investigate redox the AMPK-related Brain-selective kinases (BRSK) 1 2, detail broad catalytic activity directly through reversible reduction evolutionarily conserved...
In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications (PTMs), including phosphorylation Ser/Thr residues and oxidation cysteine (Cys) residues. While regulation activation segment well understood, relatively little known about how modulate catalysis. this study, we investigate redox the AMPK-related Brain-selective kinases (BRSK) 1 2, detail broad catalytic activity directly through reversible reduction evolutionarily conserved Cys within...
In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications (PTMs), including phosphorylation Ser/Thr residues and oxidation cysteine (Cys) residues. While regulation activation segment well understood, relatively little known about how modulate catalysis. this study, we investigate redox the AMPK-related Brain-selective kinases (BRSK) 1 2, detail broad catalytic activity directly through reversible reduction evolutionarily conserved Cys within...