A5080136568- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Hip disorders and treatments
- Hip and Femur Fractures
- Bone fractures and treatments
- Diabetic Foot Ulcer Assessment and Management
- Cardiac Valve Diseases and Treatments
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Orthopedic Surgery and Rehabilitation
- Hernia repair and management
- Cardiac Imaging and Diagnostics
- Pregnancy-related medical research
- Healthcare Systems and Technology
- Surgical site infection prevention
- Musculoskeletal Disorders and Rehabilitation
- Bone Tissue Engineering Materials
- Advanced X-ray and CT Imaging
- Chemokine receptors and signaling
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- COVID-19 and healthcare impacts
University Hospital Bonn
2018-2025
University of Bonn
2017-2024
Bacterial antibiotic resistance is an important challenge that the healthcare system continually battling and a major problem in treatment of musculoskeletal infections such as periprosthetic joint infections. Current methods to identify infectious microbes define susceptibility antibiotics require two ten days from isolation establishment antibiogram. This slow process limits advances antimicrobial drug discovery and, clinical context, delays delivery targeted treatments, with potentially...
Objectives The purpose of this study was to assess the impact COVID-19 pandemic on orthopedic and trauma surgery in private practices hospitals Germany. Design In cross-sectional study, an online-based anonymous survey conducted from April 2th 16th 2020. Setting among 15.0000 18.000 surgeons Germany, both hospitals. Participants All members German Society Orthopedic Trauma Surgery (DGOU) Professional Association for (BVOU). were invited by e-mail participate survey. Main outcome measures Out...
Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated effect wear products Ta on peri-implant cells, their potential contribution to aseptic implant loosening. This study aimed at examining cytotoxicity, oxidative stress, proinflammatory TiO2 nanoparticles (NPs) macrophages vitro. NPs were characterized using...
Evidence states that persons with hemophilia are frequently affected by low bone mineral density (BMD). Data assessing the relationship between severity of and occurrence osteoporosis lacking.
Abstract Introduction The treatment of severe acetabular bone loss remains a difficult challenge. No classification system is available that combines intuitive use, structured design and offers therapeutic recommendation according to the current literature modern state art options. goal this study introduce an intuitive, reproducible reliable guideline for evaluation defects. Methods proposed Acetabular Defect Classification (ADC) based on integrity rim supporting structures. It consists 4...
The complex field of femoral defects in revision hip arthroplasty displays a lack standardized, intuitive pre- and intraoperative assessment. To address this issue, the defect classification (FDC) is introduced to offer reliable, reproducible an system with clear therapeutic guideline.The FDC based on integrity main segments which determine function structural support. It focuses neck, metaphysis consisting greater lesser trochanter, diaphysis. four categories location while subcategories a,...
Infection is one of the most challenging complications after total joint arthroplasties affecting up to 30,000 patients in US per year. This study investigates psycho-social burden induced by two-stage intervention infected hip or knee replacements. All were treated with a exchange and assessed at three different timepoints regarding their psychological conditions. Our findings suggest that sequelae treatment periprosthetic infection are clearly underestimated literature correlates side...
Abstract Introduction Due to the current COVID-19 pandemic, German Health Ministry has issued restrictions applying field of orthopaedics and trauma surgery. Besides postponement elective surgeries, outpatient consultations have been drastically reduced. Parallel these developments, an increase in telemedical reflected efforts provide sufficient patient care. This study aims evaluate feasibility a clinical examination hip joint pelvis by way consultation. Materials Methods Twenty-nine...
Inflammation models are widely used in the vitro investigation of new therapeutic approaches for osteoarthritis. TNFα (tumor necrosis factor alpha) plays an important role inflammatory process. Current inflammation lack uniformity and make comparisons difficult. Therefore, this study aimed to systematically investigate whether effects concentration-dependent chondrocyte expansion has effect on model. Bovine chondrocytes were enzymatically isolated, expanded passages 1-3, transferred into a...
Inflammation models with the proinflammatory cytokine interleukin-1β (IL-1β) are widely used in vitro investigation of new therapeutic approaches for osteoarthritis (OA). The aim this study was to systematically analyze influence IL-1β a 3D chondral pellet culture model. Bovine articular chondrocytes were cultured passage 3 and then placed culture. Titration (100–0.1 ng/mL) performed both human bovine recombinant protein chondrocyte 2 weeks. Gene expression anabolic (collagen 2, aggrecan,...
In times of a pandemic threat, such as COVID-19, and the need for reduced direct doctor-patient contact, internet-based telemedicine has attracted more attention surrogate service. Suspending diagnosis treatment non-virus related diseases longer periods time is not viable option since this would only exacerbate problems on patient national level. The alternative modalities increased rather quickly. So far, telemedical applications have mainly focused teleradiological diagnosis, follow-up...
The purpose of this study was to describe and analyse the most severe casualties from flash flood mudslides occurring on 14 July 2021 in Germany, focusing patients who were treated closest largest level I trauma centre region disaster occurred.A single-centre retrospective design employed, all because flooding needed inpatient treatment documented. Data each patient's demographic characteristics, type injury, number surgeries, duration hospitalisation, operation time, revision rate, injury...
Abstract Background In recent literature, the increasing number of medical litigations, both in terms cases being filed and substantive costs associated with lawsuits, has been described. This study aims to provide an overview profile litigation for orthopedic trauma surgery describe differences development over time. Patients Materials A retrospective review all litigations between 2000 2017 was conducted using institutional legal database. The causes were documented classified into seven...
Abstract Background In the continuity equation, assumption of a round‐shaped left ventricular outflow tract (LVOT) leads to underestimation true aortic valve area in two‐dimensional echocardiography. The current study evaluated whether inclusion LVOT area, as measured by computed tomography (CT), reclassifies degree stenosis (AS) and assessed impact on patient outcome after transcatheter replacement (TAVR). Methods Results Four hundred twenty‐two patients with indexed index (AVAi) <0.6 cm...
Injuries of the acetabulum are often challenging in treatment and aftercare. One reason is required surgical approach, which has high complication rates, including vascular lesion, hernias, wound infection. We present an alternative endoscopic-assisted approach for internal fixation acetabular fractures to avoid Pfannenstiel incision. An endoscopic similar that used hernia surgery was used. The ilioinguinal approach's lateral window achieve reduction insertion a reconstruction plate. purpose...
The planning and implantation of a customized partial pelvis replacement places high demands on both the surgeon entire team (engineer, assistants, surgical team). Thanks to careful preoperative meticulous perioperative execution, pelvic represents complex but reliable procedure for defect reconstruction even with highly acetabular bone defects or after multiple previous surgeries.Die Planung und Implantation eines individuellen Beckenteilersatzes stellt hohe Anforderungen sowohl an den...