A5086970973- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Melanoma and MAPK Pathways
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Global Cancer Incidence and Screening
- COVID-19 Clinical Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- BRCA gene mutations in cancer
Fortis Memorial Research Institute
2024-2025
Rajiv Gandhi Cancer Institute and Research Centre
2019-2024
Creative Commons
2023
Tata Memorial Hospital
2019-2021
Advanced Centre for Treatment, Research and Education in Cancer
2019-2021
Homi Bhabha National Institute
2021
Population Services International
2020
Manipal Academy of Higher Education
2019
Kasturba Medical College, Manipal
2018-2019
The prognosis of lung carcinoma has changed since the discovery molecular targets and their specific drugs. Somatic Epidermal Growth Factor Receptor (EGFR) mutations have been reported in carcinoma, these mutant proteins act as substrates for targeted therapies. However, a resource-constrained country like India, panel-based next-generation sequencing cannot be made available to population at large. Additional challenges such adequacy tissue case core biopsies locating suitable tumour...
Background Colorectal cancer (CRC) is a heterogeneous disease morphologically, histologically, and molecularly. Most of the studies are on this molecular heterogeneity their clinicopathological correlation from western world. Very few have been done in India. Objectives The aims study were to evaluate clinical pathological profile CRCs, determine frequency subtypes correlate between features, association different CRC. Materials Methods A prospective noninvasive interventional was 50...
Abstract Background Interprofessional team-based care has been known to aid in better patient focused and outcomes. However, the same concept space of BMT (bone marrow transplant) especially this part world is currently elusive. This single center experience from a unit India depicts effectiveness interdisciplinary care. Methods An team was built experts different medical allied specialties were onboarded along with establishment state-of-the-art laboratories. The conceptualization an...
Patients with Non-small Cell Lung Cancer (NSCLC) presenting Mesenchymal–epithelial transition exon 14 skipping mutation (MET ex14) have an unfavorable prognosis traditional therapies. MET inhibitors altered the therapeutic paradigm of NSCLC. ex14 alteration is reported in 3–4% cases (N Engl J Med 383(10):944-957, 2020, Discov 5(8):842-9, 2015). Randomized controlled trials noteworthy outcomes selective tyrosine kinase (TKIs), however real-world data from Indian sub-continent lacking. The...
A 22 year-old male, a known case of Chronic Myeloid Leukemia (CML) on Nilotinib for 1 year, presented with weakness. On evaluation, complete blood count (CBC) showed hyperleukocytosis (TLC- 2,06090/ul) thrombocytopenia (platelet count-69 000/ul) and hemoglobin 12.6 g/dL. Peripheral smear 86% circulating blasts, many (~56%) showing coarse basophilic granules (Figure 1A). immunophenotyping by flow cytometry 2A–F), blasts comprised 83%, two sub-populations identified. One sub-population,...
Anaplastic lymphoma kinase (ALK) rearranged non-small cell lung carcinoma (NSCLC) is a distinct molecular subtype and rapid approval of ALK tyrosine inhibitors (TKIs) has necessitated sensitive diagnostic modalities for the detection this alteration. Gene rearrangements can be identified using many techniques including fluorescence in situ hybridisation (FISH), reverse transcriptase-PCR, next-generation sequencing (NGS) immunohistochemistry (IHC) fusion oncoprotein expression. We aimed to...
Background: Patients with cancer are at an increased risk of severe coronavirus disease-2019 (COVID-19). Hence, safe and efficacious vaccination against COVID-19 may play a crucial role in conferring protection to this group patients. Objectives: As there no dedicated trials testing the safety efficacy vaccines immunocompromised individuals or patients cancer, we conducted study assess status Indian cancer. Materials Methods: This single-center observational was Department Medical Oncology...
The GTF2I is a general transcription factor and its mutations have been reported to be recurrent in thymic epithelial tumours are rare other malignancies. Apart from tumours, these also subgroup of T cell lymphomas, angioimmunoblastic lymphomas. Soft tissue angiofibroma has harbour - NCOA2 fusion, whereas partners with Retinoic acid receptor alpha (RARA) acute promyelocytic leukaemia as RARA . implicated immune disorders two neuropsychiatric genetic disorders, namely autism Williams-Beuren...
Background: Biomarker-driven lung adenocarcinomas involving alterations in oncogenic drivers such as EGFR, ALK, ROS1, and NTRK have witnessed a dramatic shift the therapeutic prognostic landscape owing to development of molecular targeted therapies. The recent approval selective RET inhibitor, selpercatinib, has led an ardent interest RET-rearranged non-small cell carcinoma (NSCLC). However, sequential single-gene testing cannot detect rearrangements accurately or characterize fusion...
e13758 Background: National and International recommendations mandate panel- based biomarker testing for all advanced cases of NSCLC. However, analogous to uptake many other state the art cancer management strategies, NGS subsequent targeted therapy varies greatly across socio-demographic groups, explained by awareness economic restraints. This study investigates potential differences in precision medicine NSCLC patients from India. Methods: is a single center non-interventional where...
e21044 Background: Almost 70% of cases lung cancer are diagnosed at advanced stage, albeit with sophisticated imaging modalities available. Of these, 35% tiny nodules that often missed initial radiological screening, owing to limitations resolution human vision.Dramatic shift in therapeutic paradigm the management last decade has ushered an era stratified medicine. In India, one-third population inhabits rural lands;lack awareness for molecular medicine poses challenges treating oncologists....
Aims The present study investigated the incidence and spectrum of human epidermal growth factor receptor 2 (HER2) mutations, associated clinicopathological characteristics co-occurrence HER2 gene amplification in mutated cases non-small cell lung cancer (NSCLC). Methods All patients with advanced adenocarcinoma (LUAD) who underwent broad genomic profiling by next generation sequencing (NGS) from 2015 to 2019 were included study. was checked all cases. Tumour tissues examined fluorescent situ...