A5066093907- Mycobacterium research and diagnosis
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Tuberculosis Research and Epidemiology
- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Carbohydrate Chemistry and Synthesis
- Microbial Metabolism and Applications
- Plant biochemistry and biosynthesis
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2022-2025
University of Bayreuth
2024-2025
Helmholtz Centre for Infection Research
2024
Medizinische Hochschule Hannover
2024
German Center for Lung Research
2024
Friedrich Schiller University Jena
2024
Mycofactocin is a redox cofactor essential for the alcohol metabolism of mycobacteria.. While biosynthesis mycofactocin well established, gene mftG , which encodes an oxidoreductase glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes are almost exclusively found in genomes containing biosynthetic genes and present 75% organisms harboring these genes. Gene deletion experiments Mycolicibacterium smegmatis demonstrated growth defect Δ...
Mycofactocin is a redox cofactor essential for the alcohol metabolism of mycobacteria. While biosynthesis mycofactocin well established, gene mftG , which encodes an oxidoreductase glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes are almost exclusively found in genomes containing biosynthetic genes and present 75% organisms harboring these genes. Gene deletion experiments Mycolicibacterium smegmatis demonstrated growth defect ∆...
Mycobacteria produce several unusual cofactors that contribute to their metabolic versatility and capability survive in different environments. Mycofactocin (MFT) is a redox cofactor involved ethanol metabolism. The redox-active core moiety of mycofactocin derived from the short precursor peptide MftA, which modified by maturases. Recently, it has been shown decorated β-1,4-glucan chain. Remarkably, second glucose oligosaccharide chain was found be 2-O-methylated Mycolicibacterium smegmatis....
Mycofactocin is a redox cofactor essential for the alcohol metabolism of mycobacteria. While biosynthesis mycofactocin well established, gene mftG, which encodes an oxidoreductase glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes are almost exclusively found in genomes containing biosynthetic genes and present 75% organisms harboring these genes. Gene deletion experiments Mycolicibacterium smegmatis demonstrated growth defect ∆mftG...
Abstract Mycofactocin is a redox cofactor essential for the alcohol metabolism of Mycobacteria. While biosynthesis mycofactocin well established, gene mftG , which encodes an oxidoreductase glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes strictly require mft biosynthetic genes and are found in 75% organisms harboring these genes. Gene deletion experiments Mycolicibacterium smegmatis demonstrated growth defect Δ mutant on ethanol as...
Mycofactocin is a redox cofactor essential for the alcohol metabolism of Mycobacteria. While biosynthesis mycofactocin well established, gene mftG , which encodes an oxidoreductase glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes strictly require mft biosynthetic genes and are found in 75% organisms harboring these genes. Gene deletion experiments Mycolicibacterium smegmatis demonstrated growth defect Δ mutant on ethanol as carbon...
Mycofactocin is a redox cofactor essential for the alcohol metabolism of Mycobacteria. While biosynthesis mycofactocin well established, gene mftG , which encodes an oxidoreductase glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes strictly require mft biosynthetic genes and are found in 75% organisms harboring these genes. Gene deletion experiments Mycolicibacterium smegmatis demonstrated growth defect Δ mutant on ethanol as carbon...