A5024618517- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Computational Drug Discovery Methods
- Collagen: Extraction and Characterization
- Immune Response and Inflammation
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Marine Biology and Environmental Chemistry
- Augmented Reality Applications
- Osteoarthritis Treatment and Mechanisms
- Spatial Cognition and Navigation
- Reproductive Biology and Fertility
- Quality and Management Systems
- Knowledge Management and Sharing
- Information Systems Education and Curriculum Development
- Big Data and Business Intelligence
- Protease and Inhibitor Mechanisms
- Occupational Health and Safety in Workplaces
- Pluripotent Stem Cells Research
- Occupational Health and Safety Research
- Epigenetics and DNA Methylation
- Microfluidic and Capillary Electrophoresis Applications
- Virus-based gene therapy research
- Enzyme Structure and Function
- CRISPR and Genetic Engineering
University of Turku
2017-2023
Åbo Akademi University
1999-2023
Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced DUX4 expression substantially alters chromatin accessibility of non-coding DNA and activates thousands newly identified transcribed enhancer-like regions, preferentially located within ERVL-MaLR repeat elements. CRISPR activation enhancers by C-terminal motifs results increased target embryonic genome (EGA) genes ZSCAN4 KHDC1P1. We markedly enriched zygotes, followed intense...
Integrins are cell surface receptors for several microbial pathogens including echovirus 1 (EV1), a picornavirus. Cryo-electron microscopy revealed that the functional domain (α2I) of human α2β1 integrin binds to depression on EV1 capsid. This three-dimensional structure bound α2I provides first structural details an interacting with The model indicates cannot simultaneously bind both and physiological ligand collagen. Compared collagen binding domain, virus 10-fold higher affinity but in...
The development and production of innovative protein-based therapeutics is a complex challenging avenue. External conditions such as buffers, solvents, pH, salts, polymers, surfactants, nanoparticles may affect the stability integrity proteins during formulation. In this study, poly (ethylene imine) (PEI) functionalized mesoporous silica (MSNs) were used carrier for model protein bovine serum albumin (BSA). To protect inside MSNs after loading, polymeric encapsulation with (sodium...
αI domain integrins have been found in the ascidian Ciona intestinalis . We produced α1I as a recombinant protein. It did not recognize fibril‐forming collagens or bind to GFOGER other similar motifs triple‐helical peptides. No were collagens. As bound collagen IX, we propose that before emergence of GFOGER‐dependent receptors vertebrates, might able with alternative mechanisms.
In oocyte to embryo transition, the fertilized undergoes final maturation and genome is gradually activated during first three cell divisions. How this transition coordinated which factors drive processes in humans largely unknown. Here we studied role of double homeodomain transcription factor DUX4 regulating human transition. knockdown zygotes show delayed transcriptome reprogramming days after fertilization. Our combined experimental approaches allowed integrated analysis on...
Technical progress is rapid in aviation and automotive engineering. Even if these branches are different many ways, they also have similarities, especially the technical service sectors. Quite a few technological innovations were first used aircraft, and, after years, those received their own applications Because of development, it important to determine what knowledge skills will be needed future. This information predicts main directions for education future mechanics. The focus our study...