A5069579439- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- vaccines and immunoinformatics approaches
- Vaccine Coverage and Hesitancy
- Surface Chemistry and Catalysis
- Statistical Methods in Clinical Trials
- Financial Literacy, Pension, Retirement Analysis
- Supramolecular Self-Assembly in Materials
- Private Equity and Venture Capital
- Pickering emulsions and particle stabilization
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Bioinformatics, and Biomedical Research
- Prion Diseases and Protein Misfolding
- Opinion Dynamics and Social Influence
- Game Theory and Applications
- Viral gastroenteritis research and epidemiology
- Advanced biosensing and bioanalysis techniques
- Financial Markets and Investment Strategies
- Biomedical and Engineering Education
- Cardiac pacing and defibrillation studies
- COVID-19 epidemiological studies
- Housing Market and Economics
- Innovation Policy and R&D
- Amyotrophic Lateral Sclerosis Research
- CRISPR and Genetic Engineering
Massachusetts Institute of Technology
2019-2023
IIT@MIT
2022
National Bureau of Economic Research
2022
Institut National de la Recherche Scientifique
2013
Investigations of the self-assembly simple molecules at solution/solid interface can provide useful insight into general principles governing supramolecular chemistry in two dimensions. Here, we report on assembly 3,4',5-biphenyl tricarboxylic acid (H3BHTC), a small hydrogen bonding unit related to much-studied 1,3,5-benzenetricarboxylic (trimesic acid, TMA), which investigate using scanning tunneling microscopy (STM) and density functional theory (DFT) calculations. STM images show that...
A fixed one-sided significance level of 5% is commonly used to interpret the statistical randomized clinical trial (RCT) outcomes. While it necessary reduce false positive rate, threshold could be chosen quantitatively and transparently specifically reflect patient preferences regarding benefit–risk tradeoffs as well other considerations. How can explicitly incorporated into RCTs in Parkinson’s disease (PD), what impact on thresholds for device approval? In this analysis, we apply Bayesian...
Abstract Background We consider two key challenges that early-stage biotechnology firms face in developing a sustainable financing strategy and business model: valuation model for drug compounds, choosing an appropriate operating corporate structure. use the specific example of Unravel Biosciences—a therapeutics platform company identifies novel targets through off-target mechanisms existing drugs then develops optimized new molecules—throughout paper explore scenario repurposing rare...
The portfolio approach of financing drug development has been proposed as a financial innovation to improve the risk/return tradeoff investment in projects through use diversification and securitization. By investing sizable well-diversified novel candidates, issuing equity securitized debt based on this portfolio, performance such biomedical "megafund" can be made attractive wide group investors private sector. To analyze viability expediting vaccine against emerging infectious diseases, we...
The COVID-19 pandemic has raised awareness about the global imperative to develop and stockpile vaccines against future outbreaks of emerging infectious diseases (EIDs). Prior pandemic, vaccine development for EIDs was stagnant, largely due lack financial incentives pharmaceutical firms invest in research (R&D). This R&D requires significant capital investment, most notably conducting clinical trials, but generate much less profit compared with other therapeutics disease areas such as...
Following the approval by FDA of two COVID-19 vaccines, which are administered in doses three to four weeks apart, we simulate effects various vaccine distribution policies on cumulative number infections and deaths United States presence shocks supply vaccines. Our forecasts suggest that allocating more than 50% available individuals who have not received their first dose can significantly increase lives saved reduce infections. We find a allocation saves average 33% lives, prevents 32%...
Provide US FDA and amyotrophic lateral sclerosis (ALS) society with a systematic, transparent, quantitative framework to evaluate the efficacy of ALS therapeutic candidate AMX0035 in its phase 2 trial, which showed statistically significant effects (p-value 3%) slowing rate progression on relatively small sample size 137 patients. We apply Bayesian decision analysis (BDA) determine optimal type I error (p-value) under clinical evidence supports approval. Using rigorous estimates disease...
We use a global survey of over 22,400 individual investors, 4,892 financial advisors, and 2,060 institutional investors between 2015 2017 to elicit their asset allocation behavior risk preferences. find substantially different among these three groups market participants. Most exhibit highly contrarian reactions past returns in equity allocations. Financial advisors are also mostly contrarian; few them demonstrate passive behavior. However, tend extrapolate performance. clustering algorithm...