A5073826847- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Polyamine Metabolism and Applications
- Food Allergy and Anaphylaxis Research
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Lymphatic System and Diseases
- Enzyme function and inhibition
- Long-Term Effects of COVID-19
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Educational Methods and Impacts
- Nanoparticles: synthesis and applications
- COVID-19 Clinical Research Studies
- Psoriasis: Treatment and Pathogenesis
- Air Quality and Health Impacts
- Immunotherapy and Immune Responses
University of Naples Federico II
2022-2024
World Health Organization - Italy
2023-2024
Institute for Experimental Endocrinology and Oncology
2022
National Research Council
2022
COVID-19 is a viral disease caused by SARS-CoV-2. This characterized primarily, but not exclusively, respiratory tract inflammation. SARS-CoV-2 infection relies on the binding of spike protein to ACE2 host cells. The virus uses protease TMPRSS2 as an entry activator. Human lung macrophages (HLMs) are most abundant immune cells in and fulfill variety specialized functions mediated production cytokines chemokines. aim this project was investigate effects HLM activation expression HLMs. Spike...
The anthropogenic particulate matter (PM), suspended air dust that can be inhaled by humans and deposited in the lungs, is one of main pollutants industrialized cities atmosphere. Recent studies have shown PM has adverse effects on respiratory diseases. These are mainly due to ultrafine particles (PM0.1, < 100 nm), which, thanks their size, efficiently nasal, tracheobronchial, alveolar regions. Pulmonary macrophages a heterogeneous cell population distributed different lung compartments,...
Thymic stromal lymphopoietin (TSLP), mainly expressed by epithelial cells, plays a central role in asthma. In humans, TSLP exists two variants: the long form (lfTSLP) and shorter isoform (sfTSLP). Macrophages (HLMs) mast cells (HLMCs) are close proximity human lung play key roles We evaluated early proteolytic effects of tryptase chymase released HLMCs on mass spectrometry. also investigated whether its fragments generated these enzymes induce angiogenic factor release from HLMs. Mass...
Background: An emerging body of evidence indicates an association between anthropogenic particulate matter (PM) and neurodegeneration. Although the historical focus PM toxicity has been on cardiopulmonary system, ultrafine particles can also exert detrimental effects in brain. However, only a few studies are available harmful interaction CNS putative pathomechanisms. Methods: Ultrafine with diameter < 0.1 μm (PM0.1) nanoparticles 20 nm (NP20) were sampled lab-scale combustion system. Their...
Hereditary angioedema (HAE) is a rare genetic disorder characterized by local, self-limiting edema due to temporary increase in vascular permeability. HAE with normal C1 esterase inhibitor (C1INH) activity includes the form mutations F12 gene encoding for coagulation factor XII (FXII-HAE) causing an overproduction of bradykinin (BK) leading attack. BK binding B2 receptors (BK2R) leads activation phospholipase C (PLC) and subsequent generation second messengers: diacylglycerols (DAGs)...
Introduction The Janus kinase (JAK) family includes four cytoplasmic tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) constitutively bound to several cytokine receptors. JAKs phosphorylate downstream signal transducers activators of transcription (STAT). JAK-STAT5 pathways play a critical role in basophil mast cell activation. Previous studies have demonstrated that inhibitors JAK-STAT pathway blocked the activation cells basophils. Methods In this study, we investigated vitro effects...
Neutrophils (polymorphonuclear leukocytes, PMNs) are the most abundant subtype of white blood cells and among main actors in inflammatory response. Psoriatic arthritis (PsA) is a chronic disease affecting both axial peripheral joints. Typically associated with psoriasis, PsA can also affect multiple systems organs, including nails entheses. Despite involvement PMNs PsA, their specific role remains poorly understood. This study aimed to characterize biological functions neutrophil-related...
Background Thymic stromal lymphopoietin (TSLP), a pleiotropic cytokine mainly expressed by epithelial cells, plays key role in asthma pathobiology. In humans, TSLP exists two variants: the long form (lfTSLP) and shorter isoform (sfTSLP), overlapping lfTSLP C-terminus. Macrophages (HLMs) mast cells (HLMCs) are close proximity human lung play central roles different phenotypes. Methods Immunofluorescence Western blot were employed to localize intracellular TSLP. Limited proteolysis mass...
Abstract High levels of human group IIA secreted phospholipase A 2 (hGIIA) have been associated with various inflammatory disease conditions. We recently shown that hGIIA activity and concentration are increased in the plasma patients hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) negatively correlate C1-INH activity. In this study, we analyzed whether presence both impairs their respective function on immune cells. hGIIA, but not recombinant plasma-derived C1-INH,...