- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Luminescence Properties of Advanced Materials
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- GaN-based semiconductor devices and materials
- Nanocluster Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- Perovskite Materials and Applications
- Nanopore and Nanochannel Transport Studies
- Biocrusts and Microbial Ecology
- Nanowire Synthesis and Applications
- Organic Light-Emitting Diodes Research
- Advanced Decision-Making Techniques
- Advanced Computational Techniques and Applications
- Yeasts and Rust Fungi Studies
- Advancements in Battery Materials
- Chromium effects and bioremediation
- Microbial Community Ecology and Physiology
- Trace Elements in Health
- Micro and Nano Robotics
- Sulfur Compounds in Biology
Nankai University
2023-2025
Kunming University of Science and Technology
2022-2025
Fuzhou University
2021-2024
Tan Kah Kee Innovation Laboratory
2021-2022
Henan Normal University
2015
Cu2+ is closely related to the occurrence and development of Wilson's disease (WD), quantitative detection various copper indicators (especially liver Cu2 urinary Cu2+) key step for early diagnosis WD in clinic. However, clinic approach was mainly based on testing tissue through combined invasive biopsy ICP-MS method, which painful patient limited determining status real-time. Herein, we rationally designed a type Cu2+-activated nanoprobe nanogapped gold nanoparticles (AuNNP)...
Abstract Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage (ca. 100/75/50/25 %) are presented. The internal between the partial and core caused asymmetric optical behavior; tunability depends on degree structural asymmetry. shell‐to‐shell or core‐to‐core JAuNNDs(50 were self‐assembled from amphiphilic JAuNNPs(50 by tuning hydrophilic hydrophobic polymer brushes shell. positions electromagnetic field enhancement JAuNNDs varied geometrical configurations...
As key characteristic molecules, several H2S-activated probes have been explored for colon cancer studies. However, a few ratiometric fluorescence (FL) with NIR-II emissions reported the quantitative detection of H2S in vivo. Here, we developed an situ H2S-activatable nanoprobe two emission signals and intelligently lighting up cancer. The comprised down conversion nanoparticle (DCNP), which emitted FL at 1550 nm on irradiation 980 laser (F1550Em, 980Ex). Further, human serum albumin (HSA)...
Delays in evaluating cancer response to radiotherapy (RT) usually reduce therapy effect or miss the right time for treatment optimization. Hence, exploring timely and accurate methods enabling one gain insights of RT are highly desirable. In this study, we have developed an apoptosis enzyme (caspase-3) activated nanoprobe early evaluation efficacy. The bridged nanogapped gold nanoparticles (AuNNPs) second near-infrared window (NIR-II) fluorescent (FL) molecules (IR-1048) through a caspase-3...
Owing to the high sensitivity and spatial resolution, fluorescence (FL) imaging has been widely applied for visualizing biological processes. To gain insight into molecular events on deeper tissues, photoacoustic (PA) with better deep-tissue capability can be incorporated provide complementary visualization quantitative information pathological status. However, development of activatable probes achieve both FL PA signal amplification remains challenging because enhancement light absorption...
The diagnosis of disease biomarkers is crucial for the identification, monitoring, and prognostic assessment malignant disease. However, biological samples with autofluorescence, complex components, heterogeneity pose major challenges to reliable biosensing. Here, we report self-assembly natural proteins triplet–triplet annihilation upconversion (TTA-UC) pair form upconverted protein clusters (∼8.2 ± 1.1 nm), which were further assembled into photon supramolecular assemblies (PUSA). This...
Abstract Controlling the structural order of nanoparticles (NPs), morphology, and composition is paramount significance in tailoring physical properties nanoassembly. However, commonly reported symmetrical nanocomposites often suffer an interference or sacrifice photophysical original components. To address this challenge, we developed a novel type organic‐inorganic Janus nanocomposite (JNCP) with asymmetric architecture, offering unique features such as precisely controlled localization...
Abstract Nowadays, cardiovascular and cerebrovascular diseases caused by venous thromboembolism become main causes of mortality around the world. The current thrombolytic strategies in clinics are confined primarily due to poor penetration nanoplatforms, limited efficiency, extremely‐low imaging accuracy. Herein, a novel nanomotor (NM) is engineered combining iron oxide/perfluorohexane (PFH)/urokinase (UK) into liposome nanovesicle, which exhibits near‐infrared/ultrasound (NIR/US) triggered...
Abstract Overuse of herbicides poses a serious threat to ecosystems and human health; thus, the accurate determination herbicide residue is very meaningful. Thanks advantage no background fluorescence interference, upconversion luminescence allows for reliable analysis target molecules in complicated samples. Here, through screening 20 natural amino acids, it discovered that photooxidation methionine exhibited fastest recovery rate triplet‐triplet annihilation (TTA‐UC) via oxygen...
Near-infrared (NIR) to blue triplet-triplet annihilation upconversion (TTA-UC) shows unique applications in optogenetics, photocaging, and stereoscopic three-dimensional printing, etc. Here, we disclose a strategy that narrowed the energy gap between triplet states of NIR photosensitizer annihilator, with aim maximally suppressing photoexcitation loss during TET. Hence, produced NIR-to-blue TTA-UC pair exhibited an exceptionally large anti-Stokes shift (0.76 eV) achieved record quantum yield...
Abstract The development of long‐wavelength excitable solid upconversion materials and the regulation exciton behavior is important for solar energy harvesting, photocatalysis, other emerging applications. However, approaches regulating diffusion are very limited, resulting in extremely poor photonic performance solid‐state. Here, annihilation unit integrated into porous aromatic frameworks (PAFs) loaded with photosensitizer to construct efficient 721 nm‐excitable material (upconversion...
Abstract Wilson's disease (WD) is a rare inherited disorder of copper metabolism with pathological hyperaccumulation in some vital organs. However, the clinical diagnosis technique WD complicated, aggressive, and time‐consuming. In this work, novel ratiometric photoacoustic (PA) imaging nanoprobe NIR‐II window developed to achieve noninvasive, rapid, accurate Cu 2+ quantitative detection vitro vivo. The consists ‐responsive IR970 dye nonresponsive palladium‐coated gold nanorod (AuNR‐Pd),...
A localized surface plasmon (LSP) coupling nanorod <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu $ </tex-math></inline-formula> LED using graphene as a transparent conductive electrode structure was demonstrated. The optical performance of the with LSP is enhanced by about 36% in external quantum efficiency and 84% photoluminescence measurements compared LSP-free sample. This enhancement relies on...
Systemic cancer therapy is always accompanied with toxicity to normal tissue, which has prompted concerted efforts develop precise treatment strategies. Herein, we firstly an approach that enables spatiotemporally controlled formation and rotation of magnetic nanochains in vivo, allowing for mechanotherapy tumor. The nanochain comprised nanocomposites pheophorbide-A (PP) modified iron oxide nanoparticle (IONP) lanthanide-doped down-conversion NP (DCNP). In a permanent field, the would be...
Introduction Asian soybean rust is a highly aggressive leaf-based disease triggered by the obligate biotrophic fungus Phakopsora pachyrhizi which can cause up to 80% yield loss in soybean. The precise image segmentation of characterize fungal phenotype transitions during growth and help discover new medicines agricultural biocides using large-scale phenotypic screens. Methods improved Mask R-CNN method proposed accomplish densely distributed, overlapping intersecting microimages. First,...
Abstract Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage (ca. 100/75/50/25 %) are presented. The internal between the partial and core caused asymmetric optical behavior; tunability depends on degree structural asymmetry. shell‐to‐shell or core‐to‐core JAuNNDs(50 were self‐assembled from amphiphilic JAuNNPs(50 by tuning hydrophilic hydrophobic polymer brushes shell. positions electromagnetic field enhancement JAuNNDs varied geometrical configurations...
NH-μLED, namely a micro light-emitting diode structure with nano-holes dug all the way through active region, is designed to make silver nanoparticles in extremely close contact quantum wells for improving coupling between localized surface plasmon and (LSP-QWs coupling) thus enhancing optical properties of theμLED. The experimental results show that, thanks this deep nanohole structure, LSP-QWs can be realized effectively, which ultimately increases performance internal efficiency NH-μLED...
Abstract Delays in evaluating cancer response to radiotherapy (RT) usually reduce therapy effect or miss the right time for treatment optimization. Hence, exploring timely and accurate methods enabling one gain insights of RT are highly desirable. In this study, we have developed an apoptosis enzyme (caspase‐3) activated nanoprobe early evaluation efficacy. The bridged nanogapped gold nanoparticles (AuNNPs) second near‐infrared window (NIR‐II) fluorescent (FL) molecules (IR‐1048) through a...
Oxygen-mediated triplet-triplet annihilation upconversion (TTA-UC) quenching limits the application of such organic materials. Here, we report that photooxidation amines is an effective and versatile strategy to suppress oxygen-mediated in both solvents aqueous solutions. The based on dual role photooxidation, i.e., as singlet oxygen scavengers electron donors. Under photoexcitation, photosensitizer sensitizes produce for oxidation alkylamine, reducing concentration. However, photoinduced...
Abstract Controlling the structural order of nanoparticles (NPs), morphology, and composition is paramount significance in tailoring physical properties nanoassembly. However, commonly reported symmetrical nanocomposites often suffer an interference or sacrifice photophysical original components. To address this challenge, we developed a novel type organic‐inorganic Janus nanocomposite (JNCP) with asymmetric architecture, offering unique features such as precisely controlled localization...
Near-infrared light excitable triplet-triplet annihilation upconversion (NIR TTA-UC) materials have attracted interest in a variety of emerging applications such as photoredox catalysis, optogenetics, and stereoscopic 3D printing. Currently, the practical application NIR TTA-UC requires substantial improvement photostability. Here, we found that new annihilator π-expanded diketopyrrolopyrrole (π-DPP) cannot activate oxygen to generate superoxide anion via photoinduced electron transfer, its...