Hongjuan Feng

ORCID: 0000-0001-6159-0428
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Research Areas
  • Nanoplatforms for cancer theranostics
  • Luminescence and Fluorescent Materials
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Luminescence Properties of Advanced Materials
  • Photoacoustic and Ultrasonic Imaging
  • Advanced biosensing and bioanalysis techniques
  • Nanoparticle-Based Drug Delivery
  • Characterization and Applications of Magnetic Nanoparticles
  • GaN-based semiconductor devices and materials
  • Nanocluster Synthesis and Applications
  • Plasmonic and Surface Plasmon Research
  • Perovskite Materials and Applications
  • Nanopore and Nanochannel Transport Studies
  • Biocrusts and Microbial Ecology
  • Nanowire Synthesis and Applications
  • Organic Light-Emitting Diodes Research
  • Advanced Decision-Making Techniques
  • Advanced Computational Techniques and Applications
  • Yeasts and Rust Fungi Studies
  • Advancements in Battery Materials
  • Chromium effects and bioremediation
  • Microbial Community Ecology and Physiology
  • Trace Elements in Health
  • Micro and Nano Robotics
  • Sulfur Compounds in Biology

Nankai University
2023-2025

Kunming University of Science and Technology
2022-2025

Fuzhou University
2021-2024

Tan Kah Kee Innovation Laboratory
2021-2022

Henan Normal University
2015

Cu2+ is closely related to the occurrence and development of Wilson's disease (WD), quantitative detection various copper indicators (especially liver Cu2 urinary Cu2+) key step for early diagnosis WD in clinic. However, clinic approach was mainly based on testing tissue through combined invasive biopsy ICP-MS method, which painful patient limited determining status real-time. Herein, we rationally designed a type Cu2+-activated nanoprobe nanogapped gold nanoparticles (AuNNP)...

10.1021/acsnano.0c10407 article EN ACS Nano 2021-01-28

Abstract Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage (ca. 100/75/50/25 %) are presented. The internal between the partial and core caused asymmetric optical behavior; tunability depends on degree structural asymmetry. shell‐to‐shell or core‐to‐core JAuNNDs(50 were self‐assembled from amphiphilic JAuNNPs(50 by tuning hydrophilic hydrophobic polymer brushes shell. positions electromagnetic field enhancement JAuNNDs varied geometrical configurations...

10.1002/anie.202102893 article EN Angewandte Chemie International Edition 2021-03-26

As key characteristic molecules, several H2S-activated probes have been explored for colon cancer studies. However, a few ratiometric fluorescence (FL) with NIR-II emissions reported the quantitative detection of H2S in vivo. Here, we developed an situ H2S-activatable nanoprobe two emission signals and intelligently lighting up cancer. The comprised down conversion nanoparticle (DCNP), which emitted FL at 1550 nm on irradiation 980 laser (F1550Em, 980Ex). Further, human serum albumin (HSA)...

10.1021/acs.analchem.1c00427 article EN Analytical Chemistry 2021-07-01

Delays in evaluating cancer response to radiotherapy (RT) usually reduce therapy effect or miss the right time for treatment optimization. Hence, exploring timely and accurate methods enabling one gain insights of RT are highly desirable. In this study, we have developed an apoptosis enzyme (caspase-3) activated nanoprobe early evaluation efficacy. The bridged nanogapped gold nanoparticles (AuNNPs) second near-infrared window (NIR-II) fluorescent (FL) molecules (IR-1048) through a caspase-3...

10.1002/anie.202112237 article EN Angewandte Chemie International Edition 2021-12-09

Owing to the high sensitivity and spatial resolution, fluorescence (FL) imaging has been widely applied for visualizing biological processes. To gain insight into molecular events on deeper tissues, photoacoustic (PA) with better deep-tissue capability can be incorporated provide complementary visualization quantitative information pathological status. However, development of activatable probes achieve both FL PA signal amplification remains challenging because enhancement light absorption...

10.1021/acs.analchem.2c00340 article EN Analytical Chemistry 2022-03-21

The diagnosis of disease biomarkers is crucial for the identification, monitoring, and prognostic assessment malignant disease. However, biological samples with autofluorescence, complex components, heterogeneity pose major challenges to reliable biosensing. Here, we report self-assembly natural proteins triplet–triplet annihilation upconversion (TTA-UC) pair form upconverted protein clusters (∼8.2 ± 1.1 nm), which were further assembled into photon supramolecular assemblies (PUSA). This...

10.1021/jacs.4c06012 article EN Journal of the American Chemical Society 2024-07-29

Abstract Controlling the structural order of nanoparticles (NPs), morphology, and composition is paramount significance in tailoring physical properties nanoassembly. However, commonly reported symmetrical nanocomposites often suffer an interference or sacrifice photophysical original components. To address this challenge, we developed a novel type organic‐inorganic Janus nanocomposite (JNCP) with asymmetric architecture, offering unique features such as precisely controlled localization...

10.1002/anie.202105207 article EN Angewandte Chemie International Edition 2021-05-27

Abstract Nowadays, cardiovascular and cerebrovascular diseases caused by venous thromboembolism become main causes of mortality around the world. The current thrombolytic strategies in clinics are confined primarily due to poor penetration nanoplatforms, limited efficiency, extremely‐low imaging accuracy. Herein, a novel nanomotor (NM) is engineered combining iron oxide/perfluorohexane (PFH)/urokinase (UK) into liposome nanovesicle, which exhibits near‐infrared/ultrasound (NIR/US) triggered...

10.1002/adhm.202302591 article EN Advanced Healthcare Materials 2023-12-12

Abstract Overuse of herbicides poses a serious threat to ecosystems and human health; thus, the accurate determination herbicide residue is very meaningful. Thanks advantage no background fluorescence interference, upconversion luminescence allows for reliable analysis target molecules in complicated samples. Here, through screening 20 natural amino acids, it discovered that photooxidation methionine exhibited fastest recovery rate triplet‐triplet annihilation (TTA‐UC) via oxygen...

10.1002/smtd.202401945 article EN Small Methods 2025-02-14

Near-infrared (NIR) to blue triplet-triplet annihilation upconversion (TTA-UC) shows unique applications in optogenetics, photocaging, and stereoscopic three-dimensional printing, etc. Here, we disclose a strategy that narrowed the energy gap between triplet states of NIR photosensitizer annihilator, with aim maximally suppressing photoexcitation loss during TET. Hence, produced NIR-to-blue TTA-UC pair exhibited an exceptionally large anti-Stokes shift (0.76 eV) achieved record quantum yield...

10.1021/acs.nanolett.5c00117 article EN Nano Letters 2025-03-21

Abstract The development of long‐wavelength excitable solid upconversion materials and the regulation exciton behavior is important for solar energy harvesting, photocatalysis, other emerging applications. However, approaches regulating diffusion are very limited, resulting in extremely poor photonic performance solid‐state. Here, annihilation unit integrated into porous aromatic frameworks (PAFs) loaded with photosensitizer to construct efficient 721 nm‐excitable material (upconversion...

10.1002/adma.202502150 article EN Advanced Materials 2025-04-10

Abstract Wilson's disease (WD) is a rare inherited disorder of copper metabolism with pathological hyperaccumulation in some vital organs. However, the clinical diagnosis technique WD complicated, aggressive, and time‐consuming. In this work, novel ratiometric photoacoustic (PA) imaging nanoprobe NIR‐II window developed to achieve noninvasive, rapid, accurate Cu 2+ quantitative detection vitro vivo. The consists ‐responsive IR970 dye nonresponsive palladium‐coated gold nanorod (AuNR‐Pd),...

10.1002/smll.202008061 article EN Small 2021-06-03

A localized surface plasmon (LSP) coupling nanorod <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu $ </tex-math></inline-formula> LED using graphene as a transparent conductive electrode structure was demonstrated. The optical performance of the with LSP is enhanced by about 36% in external quantum efficiency and 84% photoluminescence measurements compared LSP-free sample. This enhancement relies on...

10.1109/led.2022.3217167 article EN IEEE Electron Device Letters 2022-11-03

Systemic cancer therapy is always accompanied with toxicity to normal tissue, which has prompted concerted efforts develop precise treatment strategies. Herein, we firstly an approach that enables spatiotemporally controlled formation and rotation of magnetic nanochains in vivo, allowing for mechanotherapy tumor. The nanochain comprised nanocomposites pheophorbide-A (PP) modified iron oxide nanoparticle (IONP) lanthanide-doped down-conversion NP (DCNP). In a permanent field, the would be...

10.1002/anie.202213319 article EN Angewandte Chemie International Edition 2022-10-28

Introduction Asian soybean rust is a highly aggressive leaf-based disease triggered by the obligate biotrophic fungus Phakopsora pachyrhizi which can cause up to 80% yield loss in soybean. The precise image segmentation of characterize fungal phenotype transitions during growth and help discover new medicines agricultural biocides using large-scale phenotypic screens. Methods improved Mask R-CNN method proposed accomplish densely distributed, overlapping intersecting microimages. First,...

10.3389/fpls.2024.1340584 article EN cc-by Frontiers in Plant Science 2024-03-27

Abstract Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage (ca. 100/75/50/25 %) are presented. The internal between the partial and core caused asymmetric optical behavior; tunability depends on degree structural asymmetry. shell‐to‐shell or core‐to‐core JAuNNDs(50 were self‐assembled from amphiphilic JAuNNPs(50 by tuning hydrophilic hydrophobic polymer brushes shell. positions electromagnetic field enhancement JAuNNDs varied geometrical configurations...

10.1002/ange.202102893 article EN Angewandte Chemie 2021-03-26

NH-μLED, namely a micro light-emitting diode structure with nano-holes dug all the way through active region, is designed to make silver nanoparticles in extremely close contact quantum wells for improving coupling between localized surface plasmon and (LSP-QWs coupling) thus enhancing optical properties of theμLED. The experimental results show that, thanks this deep nanohole structure, LSP-QWs can be realized effectively, which ultimately increases performance internal efficiency NH-μLED...

10.1088/1361-6528/ac8f98 article EN Nanotechnology 2022-09-06

Abstract Delays in evaluating cancer response to radiotherapy (RT) usually reduce therapy effect or miss the right time for treatment optimization. Hence, exploring timely and accurate methods enabling one gain insights of RT are highly desirable. In this study, we have developed an apoptosis enzyme (caspase‐3) activated nanoprobe early evaluation efficacy. The bridged nanogapped gold nanoparticles (AuNNPs) second near‐infrared window (NIR‐II) fluorescent (FL) molecules (IR‐1048) through a...

10.1002/ange.202112237 article EN Angewandte Chemie 2021-12-09

Oxygen-mediated triplet-triplet annihilation upconversion (TTA-UC) quenching limits the application of such organic materials. Here, we report that photooxidation amines is an effective and versatile strategy to suppress oxygen-mediated in both solvents aqueous solutions. The based on dual role photooxidation, i.e., as singlet oxygen scavengers electron donors. Under photoexcitation, photosensitizer sensitizes produce for oxidation alkylamine, reducing concentration. However, photoinduced...

10.1021/acs.nanolett.4c02529 article EN Nano Letters 2024-07-05

Abstract Controlling the structural order of nanoparticles (NPs), morphology, and composition is paramount significance in tailoring physical properties nanoassembly. However, commonly reported symmetrical nanocomposites often suffer an interference or sacrifice photophysical original components. To address this challenge, we developed a novel type organic‐inorganic Janus nanocomposite (JNCP) with asymmetric architecture, offering unique features such as precisely controlled localization...

10.1002/ange.202105207 article EN Angewandte Chemie 2021-05-27

Near-infrared light excitable triplet-triplet annihilation upconversion (NIR TTA-UC) materials have attracted interest in a variety of emerging applications such as photoredox catalysis, optogenetics, and stereoscopic 3D printing. Currently, the practical application NIR TTA-UC requires substantial improvement photostability. Here, we found that new annihilator π-expanded diketopyrrolopyrrole (π-DPP) cannot activate oxygen to generate superoxide anion via photoinduced electron transfer, its...

10.1021/acsami.3c17679 article EN ACS Applied Materials & Interfaces 2024-02-06
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