A5012381718- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Sepsis Diagnosis and Treatment
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Developmental and Educational Neuropsychology
- Anesthesia and Neurotoxicity Research
- Neurobiology and Insect Physiology Research
- Estrogen and related hormone effects
- Traumatic Brain Injury Research
- Respiratory Support and Mechanisms
- Educational Outcomes and Influences
- Aging, Health, and Disability
- Neonatal and Maternal Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetics and Neurodevelopmental Disorders
- Bacterial Infections and Vaccines
- Renin-Angiotensin System Studies
- Sleep and Wakefulness Research
Universitat Autònoma de Barcelona
2017-2024
University of North Carolina at Chapel Hill
2024
Applied Physical Sciences (United States)
2024
Departament de Salut
2020-2023
Artifex University
2020
Universidad Interamericana
2015
Hospital Universitario Virgen del Rocío
2007
Hospital Riotinto
2005
It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not other. Here, we show that chemogenetic silencing centromedial (CeM)-
Exposure to traumatic stress can lead fear dysregulation, which has been associated with posttraumatic disorder (PTSD). Previous work showed that a polymorphism in the PACAP-PAC1R (pituitary adenylate cyclase-activating polypeptide) system is PTSD risk women, and PACAP (ADCYAP1)-PAC1R (ADCYAP1R1) are highly expressed hypothalamus. Here, we show female mice subjected acute immobilization (IMO) have extinction impairments related Adcyap1 Adcyap1r1 mRNA upregulation hypothalamus, PACAP-c-Fos...
Abstract Memory formation is key for brain functioning. Uncovering the memory mechanisms helping us to better understand neural processes in health and disease. Moreover, more specific treatments fear-related disorders such as posttraumatic stress disorder phobias may help decrease their negative impact on mental health. In this line, Tachykinin 2 (Tac2) pathway central amygdala (CeA) has been shown be sufficient necessary modulation of fear consolidation. CeA-Tac2 antagonism its...
Research that combines advanced technological devices with complex behavioral tasks has enabled investigations into the neural mechanisms underlying brain and states. Freely moving rodent experiments often require a tether—a wired connection between an implanted device external power supply or data acquisition system. Traditionally, these have used passive commutators to manage tethers, but such setups are inadequate for reducing twisting mechanical strain during tasks. Existing motorized...
Abstract Neuropeptide S (NPS) is a neuropeptide involved in the regulation of fear. Because safety learning impaired patients suffering from anxiety‐related psychiatric disorders, and polymorphisms human receptor (NPSR) gene have also been associated with anxiety we wanted to investigate whether NPSR‐deficiency interferes learning, how prior stress would affect this type learning. We first investigated effect pre‐exposure two different types stressors (electric stimuli or immobilization) on...
Abstract Fear conditioning (FC) is a widely accepted tool for the assessment of learning and memory processes in rodents related to normal dysregulated acquired fear. The study sex differences fear vast currently increasing. Sex hormones have proven be crucial formation males females, several methods been developed assess this hormonal state rats mice. Herein, we explain routine FC extinction protocol, together with evaluation male female rodents. We three protocols directly from blood...
Abstract Memory formation is key for brain functioning. Uncovering the memory mechanisms helping us to better understand neural processes in health and disease. Moreover, more specific treatments fear-related disorders such as posttraumatic stress disorder phobias may help decrease their negative impact on mental health. In this line, Tachykinin 2 (Tac2) pathway central amygdala (CeA) has been shown be sufficient necessary modulation of fear consolidation. CeA-Tac2 antagonism its...
Abstract Background Memory consolidation is a process required for the formation of long-term memories. The G-protein-coupled receptor (GPCR) neurokinin-3-receptor (Nk3R) and its interactions with sex hormones seem important modulation fear memory consolidation: Nk3R antagonism in male mice impairs memory, but enhances it females. However, involvement as modulator other memories both sexes remains unexplored. Methods We use novel object recognition paradigm to test effect systemic blockade...
The importance of studying stress resilience has become more evident in the last years, considering frequency and variety stressors that humans have to deal with its association stress-related disorders, especially now than ever due COVID-19 worldwide global crisis. Hence, neurobiological basis underlying factors modulate it are a key area research Neuroscience. This book, edited by Alon Chen (Chen A, ed. Stress Resilience: Molecular Behavioral Aspects. London, England: Academic Press; 2020)...
Abstract Memory formation is key for brain functioning. Uncovering the memory mechanisms helping us to better understand neural processes in health and disease. In this line, Tachykinin 2 (Tac2) pathway central amygdala (CeA) has been shown be sufficient necessary modulation of fear consolidation. CeA-Tac2 antagonism its pharmacogenetic temporal inhibition impairs male mice. Surprisingly, we demonstrate here a totally opposite effect Tac2 blockade on enhancing consolidation females....