A5066847322- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Cystic Fibrosis Research Advances
- Transgenic Plants and Applications
- Probiotics and Fermented Foods
- Protein Hydrolysis and Bioactive Peptides
- Pediatric health and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Inhalation and Respiratory Drug Delivery
- Biochemical Analysis and Sensing Techniques
- interferon and immune responses
- Advanced Chemical Sensor Technologies
- Microbial Inactivation Methods
- Genetically Modified Organisms Research
- Infant Health and Development
- Infant Nutrition and Health
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- Consumer Attitudes and Food Labeling
- Vaccine Coverage and Hesitancy
University of Washington
2023
MemorialCare Health System
2019-2021
Miller Children's & Women's Hospital
2021
University of Nebraska–Lincoln
2013-2020
The factors that govern assembly of the gut microbiota are insufficiently understood. Here, we test hypothesis inter-individual variation can arise solely from differences in order and timing by which is colonized early life. Experiments mice were inoculated sequence either with two complex seed communities or a cocktail four bacterial strains community revealed colonization influenced both outcome ecological success individual colonizers. Historical contingency priority effects also...
Under conventional conditions, mice deficient in core 1-derived O-glycans (TM-IEC C1galt1(-/-)), which have a defective mucus layer, experienced spontaneous inflammation of the colon. Analysis fecal bacterial populations by pyrosequencing 16S rRNA gene showed that disease TM-IEC C1galt1(-/-) was associated with shifts microbiota manifested increases Lactobacillus and Clostridium species, decreases unclassified Ruminococcaceae Lachnospiraceae. germ-free (GF) presented decreased goblet cells,...
Rodent-derived strains of Lactobacillus reuteri densely colonize the forestomach mice and possess several genes whose predicted functions constitute adaptations towards an acidic environment. The objective this study was to systematically determine which L. 100-23 contribute tolerance host gastric acid secretion. Genes be involved in resistance were inactivated, their contribution survival under conditions confirmed model juice. Fitness five mutants that showed impaired vitro then compared...
Infection with influenza A virus (IAV) leads to acute lung injury and possibly fatal complications, especially in immunocompromised, elderly, or chronically infected individuals. Therefore, it is important study the factors that lead pathology mortality hosts. In this report, we analyze immune responses infection at a sublethal (0.1 LD(50)) lethal (1 dose of highly pathogenic IAV A/Puerto Rico/8/34 (PR8). Our experiments revealed 1 LD(50) induced peak viral titers day 2 compared 4 0.1 dose....
Tolerance Induction Program (TIP) immunotherapy applies machine learning contextualized on immunologic and food protein data sets. TIP has established efficacy toward peanut allergy. This form of treatment demonstrates equal cow's milk anaphylaxis. maintains remission outcomes defined as a minimum 7 days allergen unresponsiveness to high-dose exposures. Furthermore, patients openly consume unrestricted amounts dairy protein.
Cystic fibrosis (CF) is one of the most common recessively inherited disorders diagnosed in early childhood United States. Determining phenotype CF patients likely to experience a significant drop FEV1% predicted will help target efforts for mitigating this deleterious disorder.This retrospective cohort study evaluated potential risk variables that account decline 81 treated at Miller Children's and Women's Hospital, CA. disease progression (CF RD-Pro) score was as tool identify high-risk...
Background: Children with peanut allergy are regularly instructed to avoid all tree nuts. However, children likely not allergic Objective: In our cohort of patients anaphylaxis and who underwent oral immunotherapy, we sought determine the correlation skin-prick testing (SPT) results for nuts likelihood successfully passing a nut challenge. Methods: SPT was performed (macadamia, pine nut, coconut, hazelnut, brazil cashew, pecan, walnut, pistachio, almond) in 27 known allergy. The probability...
Disease-specific COVID-19 pediatric comorbidity has not been studied effectively to date. Atopy and food anaphylaxis disease states require improved characterization of SARS-CoV-2 infection risk. To provide the first such characterization, we assessed serum samples a highly atopic, anaphylactic, asymptomatic cohort from across US during height pandemic. From our biobank, 172 patient were characterized specific immunologic markers in at beginning pandemic, 1 February 20 April 2020. Clinical...