A5008080180- Radiation Therapy and Dosimetry
- Luminescence Properties of Advanced Materials
- Nanoplatforms for cancer theranostics
- Radiation Dose and Imaging
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Advanced Radiotherapy Techniques
- Inorganic Fluorides and Related Compounds
- Luminescence and Fluorescent Materials
- ZnO doping and properties
- Advanced MRI Techniques and Applications
- DNA Repair Mechanisms
- Lanthanide and Transition Metal Complexes
Shanghai Jiao Tong University
2021-2025
State Key Laboratory of Metal Matrix Composites
2021
Exploring materials that can absorb near-infrared (NIR) light to produce reactive oxygen species (ROS) is necessary for many fields. Herein we show thulium oxide nanoparticles are viable NIR-stimulated ROS generation. This property may be related the unique energy levels, large absorption cross section, low fluorescence emission, and ∼10–3 s lifetime of 3H4 state Tm ions. We further demonstrate impact these on photodynamic therapy (PDT), in which impressive tumor inhibition was recorded...
Nanoparticle-based X-ray radiosensitization strategies have garnered significant attention in recent years. However, the underlying mechanisms of remain incompletely understood. In this work, we explore influence K-edge effect absorption nanomaterials on sensitization. Due to alignment thulium (Tm) with Bremsstrahlung peak energy spectrum medical accelerators, following four different rare-earth varying Tm percentages were designed: NaTmF4, NaTm0.6Lu0.4F4, NaTm0.4Lu0.6F4, and NaLuF4. We...
Gadolinium oxide nanoparticles (GONs) have the potential to be one of best candidates for contrast agents magnetic resonance imaging. Even though influence parameters on relaxation has been substantially demonstrated, variation r1 GONs with a similar structure and surface chemistry implied our limited understanding. We herein synthesized adjustable size, shape, crystallinity, modified them series molecules different acidities, recorded their values imaging contrast. Our results showed that...
Shortened interplanar spacing of CaF 2 nanocrystals led to significant improvement their 19 F imaging capability.
Sensitizing radiation therapy (RT) for cancer is highly desired to reduce side-effect of the harsh dose irradiation, and nanoparticles with high atomic number elements provide a promising tool. However, insufficient knowledge on utilizing interaction between cancerous cells hampers improvement therapeutic outcome. We herein employed NaGdF4:Yb,Er nanocrystals as sensitizer, modified them tumor targeting agent mitochondria moiety, separately jointly, achieve varied extent mitochondrial...