A5068361167- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Muscle activation and electromyography studies
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Effects of Radiation Exposure
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Bone and Joint Diseases
- Sports injuries and prevention
- Nutrition and Health in Aging
- Extracellular vesicles in disease
- Neuroscience and Neural Engineering
- Sports Performance and Training
- Histone Deacetylase Inhibitors Research
- Viral Infections and Vectors
- Telomeres, Telomerase, and Senescence
- Adipose Tissue and Metabolism
- Sarcoma Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Cardiomyopathy and Myosin Studies
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Effects of Exercise
University of Ottawa
2020-2024
University of Calgary
2020
University of Concepción
2020
Finis Terrae University
2019
Abstract Cellular senescence is the irreversible arrest of normally dividing cells and driven by cell cycle inhibitors Cdkn2a , Cdkn1a Trp53 . Senescent are implicated in chronic diseases tissue repair through their increased secretion pro‐inflammatory factors known as senescence‐associated secretory phenotype (SASP). Here, we use spatial transcriptomics single‐cell RNA sequencing (scRNAseq) to demonstrate that displaying senescent characteristics “transiently” present within regenerating...
Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma that most often develops in children. Chemoradiation therapy a standard treatment modality; however, the detrimental long-term skeletal muscle consequences of this juvenile cancer survivors include atrophy and fibrosis resulting decreased physical performance. Using novel model murine resistance endurance exercise training, we investigate its role preventing effects RMS plus therapy.Four-week-old male (n = 10) female C57Bl/6J mice...
Radiation-induced muscle pathology, characterized by atrophy and fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic radiation exposure particularly in juvenile cancer survivors. In healthy muscle, fibro/adipogenic progenitors (FAPs) are required for maintenance regeneration, while pathology FAPs precursors exacerbated extracellular matrix deposition. However, role radiation-induced has not previously been explored.Four-week-old Male CBA or C57Bl/6J mice...
Satellite cells are required for muscle regeneration, remodeling, and repair through their activation, proliferation, differentiation; however, how dietary factors regulate this process remains poorly understood. The L-type amino acid transporter 1 (LAT1) transports acids, such as leucine, into mature myofibers, which then stimulate protein synthesis anabolic signaling. However, whether LAT1 is expressed on myoblasts involved in regulating myogenesis unknown. aim of study was to characterize...
We demonstrate that resistance training-induced increases in fiber hypertrophy, FAP content, and capillarization are similar between middle-aged males females.
The aim of this study was to examine the activation skeletal muscle signaling pathways related protein synthesis and gene expression regeneration/degradation markers following repeated bouts eccentric cycling. Nine untrained men (25.4 ± 1.9 yr) performed two 30-min cycling (ECC1, ECC2) at 85% maximal concentric workload, separated by 2 wk. Muscle biopsies were taken from vastus lateralis before h after each bout. Indirect damage assessed 24-48 exercise. Changes in Akt/mammalian target...
Exercise and obesity regulate hematopoiesis, in part through alterations cellular soluble components of the bone marrow niche. Extracellular vesicles (EVs) are niche that hematopoiesis; however, role exercise training or induced EVs regulating hematopoiesis remains unknown. To address this gap, donor were isolated from control diet-fed, sedentary mice (CON-SED), diet-fed trained (CON-EX), high fat (HFD-SED), (HFD-EX) injected into recipient undergoing stress hematopoiesis. Hematopoietic cell...
Weight loss and exercise reduce colorectal cancer (CRC) risk in persons with obesity. Whether weight effect myofibre characteristics muscle stem/progenitor cell populations mice preneoplastic lesions, a model of CRC risk, is unknown. To address this gap, male C57Bl/6J were fed high-fat diet (HFD) to induce obesity or control (CON) prior azoxymethane injection lesions. The HFD group was then randomized conditions that included (1) switching the CON only (HFD-SED) treadmill training (HFD-EX)....
ABSTRACT Purpose Obesity increases colon cancer risk that has been previously linked to marrow-derived myeloid cells. We demonstrated exercise training (EX) prevents initiation, potentially through reduced myelopoiesis. However, it remains unknown whether early cell accumulation and inflammation in the precedes carcinogenesis with high-fat diet (HFD)-induced obesity, if EX can attenuate these effects. hypothesized obesity would promote was preceded by be attenuated EX. Methods C57BL/6 mice...
Valdes, O, Inzulza, S, Collao, N, Garcia-Vicencio, Tufano, JJ, Earp, J, Venegas, M, and Peñailillo, L. Eccentric cycling is an alternative to Nordic hamstring exercise increase the neuromuscular function of knee flexors in untrained men. J Strength Cond Res 37(11): 2158-2166, 2023-Nordic (NHE) has been proposed reduce flexor (KF) injuries. However, submaximal alternatives NHE are necessary for clinical or weaker population. The aim this study was compare effects training (NHT) eccentric...