A5019638359- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Plant tissue culture and regeneration
- Bacterial biofilms and quorum sensing
- Ferroptosis and cancer prognosis
- Barrier Structure and Function Studies
- Yersinia bacterium, plague, ectoparasites research
- Vibrio bacteria research studies
- Plant-Microbe Interactions and Immunity
Pennsylvania State University
2022-2023
University of Richmond
2022
West Virginia University
2018-2020
Abstract Blood-brain barrier (BBB) dysfunction occurs in cerebrovascular diseases and neurodegenerative disorders such as stroke. Opening of the BBB during a stroke has negative impact on acute outcomes. We have recently demonstrated that miR-34a regulates by targeting cytochrome c (CYC) vitro . To investigate role stroke, we purified primary endothelial cells (pCECs) from mouse brains following 1 h transient middle cerebral artery occlusion (tMCAO) measured real-time PCR to detect levels....
Agrobacterium tumefaciens pathogenesis of plants is initiated with signal reception and culminates transforming the genomic DNA its host. The histidine sensor kinase VirA receives reacts to discrete signaling molecules for full induction genes necessary this process. Though many components process have been identified, precise mechanism how coordinates response host signals, namely phenols sugars, unknown. Recent advances molecular modeling allowed us test structure/function predictions...
Many animals form symbioses with environmental bacteria that provide biological functions beneficial to their hosts. The mechanisms affect the acquisition of bacterial symbionts remain poorly understood but are important identify develop new ways improve animal health. Vibrio fischeri is a Gram-negative bacterium forms mutualistic symbiosis Hawaiian bobtail squid Euprymna scolopes . From within light organ, these V. populations engage in quorum sensing produce bioluminescence for host...
Background: The blood-brain barrier (BBB) is a crucial interface between the central nervous system (CNS) and circulatory that maintains cerebral homeostasis by selectively allowing entry of blood solutes into CNS. BBB dysfunction has been observed in cerebrovascular diseases neurodegenerative disorders such as stroke. opened during stroke, having negative impacts on stroke outcomes. Mitochondria are key players this abnormal opening BBB, decreased cytochrome c (CYC) levels have shown...