A5002941495- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Shoulder and Clavicle Injuries
- Electrospun Nanofibers in Biomedical Applications
- Reconstructive Surgery and Microvascular Techniques
- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Orthopedic Surgery and Rehabilitation
- Surgical Sutures and Adhesives
- Health Systems, Economic Evaluations, Quality of Life
- Nerve Injury and Rehabilitation
- Healthcare cost, quality, practices
- Sports injuries and prevention
- Biomedical Ethics and Regulation
Nuffield Orthopaedic Centre
2015-2018
University of Oxford
2014-2018
NIHR Oxford Musculoskeletal Biomedical Research Centre
2016
Soft tissue injuries represent a substantial and growing social economic burden. Medical fibres are commonly used to repair these during surgery. Patient's outcomes are, however, not promising with around 40% of surgical repairs failing within the first few months after surgery due poor regeneration. The application nanofibrous filaments yarns as medical scaffolds has been suggested improve soft regeneration enhance quality repair. However, lack robustness reliability current fabrication...
Objectives All-suture anchors are increasingly used in rotator cuff repair procedures. Potential benefits include decreased bone damage. However, there is limited published evidence for the relative strength of fixation all-suture compared with traditional anchors. Materials and Methods A total four commercially available anchors, ‘Y-Knot’ (ConMed), Q-FIX (Smith & Nephew), ICONIX (Stryker) JuggerKnot (Zimmer Biomet) a anchor control TWINFIX Ultra PK Suture Anchor Nephew) were tested...
Annealing, or heat treatment, has traditionally been used as a treatment to improve the strength and stiffness of electrospun materials. Understanding extent which annealing can mechanical properties alter degradation rate polydioxanone filaments could influence range its potential clinical applications. In this study, we investigated effect at varying times temperatures subsequently subjecting them in vitro phosphate buffer saline for up 6 weeks. Fibre alignment, tensile thermal were...
Background All surgical meshes entering the U.S. market have been cleared for clinical use by 510(k) process of Food and Drug Administration (FDA), in which devices simply require proof “substantial equivalence” to predicate devices, without need trials. However, recalled associated with adverse effects may, indirectly, continue serve as predicates new raising concerns over safety route. Methodology Here we assess potential magnitude this problem determining ancestral network equivalence...
<h3>Introduction</h3> Nanofibrous electrospun materials have been previously proposed as scaffolds for tendon repair, their ability to mimic structures and encourage tissue regeneration.<sup>1,2</sup> In particular, creating filaments out of fibres offers the possibility build larger with tailored morphologies mechanical properties. this paper, we present potential a new range which could be used repair soft such tendon. <h3>Method</h3> Continuous polydioxanone (PDO) were produced single...
The healing process of ruptured tendons is suboptimal, taking months to achieve tissue with inferior properties healthy tendon. Mechanical loading has been shown positively influence tendon healing. However, high frequency low magnitude (HFLM) loads, which have promise in maintaining properties, not studied vitro injury models. Here, we present and validate an scratch model investigate effects HFLM on the injured rat tail fascicles (RTTFs). A longitudinal tear was simulated using a needle...