A5102939828- IgG4-Related and Inflammatory Diseases
- Receptor Mechanisms and Signaling
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Traumatic Ocular and Foreign Body Injuries
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Adipose Tissue and Metabolism
- Renin-Angiotensin System Studies
- Cellular transport and secretion
- Kawasaki Disease and Coronary Complications
- Cancer Cells and Metastasis
- Innovation and Knowledge Management
- Inflammasome and immune disorders
- Nitric Oxide and Endothelin Effects
- Radiation Therapy and Dosimetry
- Atherosclerosis and Cardiovascular Diseases
- Ear and Head Tumors
- Toxin Mechanisms and Immunotoxins
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Asthma and respiratory diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Peroxisome Proliferator-Activated Receptors
Nantong University
2020-2023
Northeast Agricultural University
2023
Tongji University
2011-2022
Shanghai Tenth People's Hospital
2017-2022
Fudan University
2021
Chinese Academy of Sciences
2005
Transarterial radioembolization (TARE) is considered the standard treatment for intermediate-stage hepatocellular carcinoma (HCC). Iodine-131 (131I)-labeled lipiodol TARE an effective HCC but has been withdrawn due to its poor retention in tumor lesions and significant distribution normal tissues with severe side effects. In this work, a highly tumor-specific 131I-TARE agent long-time developed by simply introducing tyrosine poly(vinyl alcohol) (PVA) drug-eluting microbeads (Tyr-PVA-DEBs)....
This study aimed to evaluate the outcomes of endoscopic optic nerve decompression (EOND) for adults with traumatic neuropathy (TON) and seek factors that might affect surgery outcomes.From January 2016 June 2019, 16 diagnosed TON, who underwent trans-ethmosphenoid canal decompression, were reviewed. All patients treated steroids before surgery. The main outcome measure was an improvement in visual acuity (VA) after treatment.Eight (50.0%) had residual vision surgery, while eight no light...
Background: In this study, we investigated the mechanism of Rho GTPases signaling on Ang II-mediated cell migration and dedifferentiation in human aortic vascular smooth muscle cells (HA-VSMCs) an II-infusion mouse model. Methods: Cells were pretreated with different inhibitors or II. Cell was detected by Wound healing Transwell assay. Mice treated Ad-RhoA-shRNA virus Irbesartan fasudil then infused Results: II treatment induced HA-VSMCs a dose- time-dependent manner reduced expression VSMC...
Allergic rhinitis (AR) is a common immunoglobulin E-mediated immune response involved various cell types, while the role of nasal fibroblasts (NFs) in pathogenesis AR less understood.The study aimed to uncover gene expression profile AR-derived NFs and potential mechanism for changed phenotype AR-NFs.The primary were isolated from 3 patients (AR-NFs) controls (Ctrl-NFs), proliferation, migration interleukins production abilities detected respectively. RNA-sequence was used identify...
Background: The pathological role of cytochrome c oxidase 5A (COX5A) in vascular neointima formation remains unknown. Aim: This study aims to investigate the COX5A on platelet-derived growth factor BB (PDGFBB)- mediated smooth muscle phenotypic modulation and clarify molecular mechanisms behind this effect. Methods: For vitro assays, human aortic cells (HA-VSMCs) were transfected with pcDNA3.1-COX5A siRNA overexpress knockdown COX5A, respectively. Mitochondrial complex IV activity, oxygen...
Emodin was extracted from Rheum officinale Baill by ultrasound-assisted extraction (UAE), and ethanol chosen as the suitable solvent through SEM molecular dynamic simulation. Under optimum conditions (power 541 W, time 23 min, liquid to material ratio 13:1 mL/g, concentration 83 %) predicted RSM, yield of emodin 2.18 ± 0.11 mg/g. Moreover, ultrasound power displayed significant effects on process. Extracting dynamics analysis indicated that process UAE conformed Fick's second diffusion law....
RhoGTPase is involved in PDGF-BB-mediated VSMC phenotypic modulation. RhoGDIs are key factors regulating activation. In the present study, we investigated regulatory effect of RhoGDI1 on activation transformation and neointima formation. Western blot co-immunoprecipitation assays showed that PDGF receptor inhibition by crenolanib promoted polyubiquitination degradation. Inhibition degradation via MG132 reversed decrease transformation. addition, knockdown significantly inhibited formation...
Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland tumor that occurs mostly in the parotid gland. We report case of EMC submandibular young man. The patient was aware slow-growing mass right for 1 year. Clinical examination and ultrasound confirmed mass, 2.5 × 3 cm2 size. Ultrasound-guided fine-needle aspiration indicated diagnosis pleomorphic adenoma, which also suggested by magnetic resonance imaging. excised. Immunohistochemical analysis showed ex adenoma with...
The mechanisms of angiotensin II (Ang II) on regulating adipogenic differentiation and function remain unknown. In this study, we focus revealing the role C-terminal-binding protein 1 (CtBP1) Ang II-mediated mature adipocyte browning. Amounts 3T3-L1 CtBP1-KO were treated with for 24 h then induced differentiation, or cells first II. expressions CtBP1 markers checked by Western blot. Transcription was assayed Real-time RT-PCR. Lipid droplet formation size detected Oil Red O. Mitochondrial...
Perivascular adipose tissue (PVAT) homeostasis plays an important role in maintaining vascular function, and PVAT dysfunction may induce several pathophysiological situations. In this study, we investigated the effect mechanism of local angiotensin II (Ang II) on PVAT. High-throughput comparative proteomic analysis, based TMT labeling combined with LC-MS/MS, were performed vivo Ang infusion mice model to obtain a comprehensive view protein ensembles associated thoracic (tPVAT) induced by II....
Inflammatory pseudotumor (IP) is a rare benign group of lesions which mimics invasive malignancies clinically and radiologically. We described five cases nasopharyngeal skull base IP treated by endoscopic surgery. These patients suffered from headache, tinnitus some symptoms posterior cranial nerve injury such as hoarseness. Three them had history type 2 diabetes mellitus four underwent mastoidectomy or puncture tympanic membrane. The diagnosis was confirmed histologically. Endoscopic...
This article has been retracted by the publisher.
Abstract Background: Bone marrow mesenchymal stem cells can promote the recovery of immune balance and regulate Th1/2 cells. Allergic rhinitis is a disease with imbalance mediated by IgE. It’s unclear whether BMSCs could AR disease. In this study, possible role was explored. Methods : mouse model established ovalbumin (OVA). 18 models were randomly divided into three groups: AR-sensitized, Stem-cell-returned, Medium-returned; six unsensitized mouses named normal-control. IgE, IL-4 INF-γ...