A5081934322- Forensic and Genetic Research
- Genetic diversity and population structure
- Identification and Quantification in Food
- Molecular Biology Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Genetic Associations and Epidemiology
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Parkinson's Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Genomics and Rare Diseases
- Endoplasmic Reticulum Stress and Disease
- Genetics, Bioinformatics, and Biomedical Research
- Nerve injury and regeneration
- Plant Virus Research Studies
- Hepatitis B Virus Studies
Southern Medical University
2014-2022
Methamphetamine (METH) is an illegal and widely abused psychoactive stimulant. METH exposure causes detrimental effects on multiple organ systems, primarily the nervous system, especially dopaminergic pathways, in both laboratory animals humans. In this study, we hypothesized that Nuclear protein 1 (Nupr1/com1/p8) involved METH-induced neuronal apoptosis autophagy through endoplasmic reticulum (ER) stress signaling pathway. To test hypothesis, measured expression levels of Nupr1, ER markers...
The over-expression of α-synuclein is a major factor in the death dopaminergic neurons methamphetamine-induced model Parkinson's disease. In present study, knockdown rats were created by injecting α-synuclein-shRNA lentivirus stereotaxically into right striatum experimental rats. At 2 weeks post-injection, injected intraperitoneally with methamphetamine to establish Expression mRNA and protein was significantly downregulated. Food intake body weight greater rats, water stereotyped behavior...
In this study, we analyzed the genetic polymorphisms of 23 Y-STR loci from PowerPlex® Y23 system in 916 unrelated healthy male individuals Chinese Jiangsu Han, and observed 912 different haplotypes including 908 unique 4 duplicate haplotypes. The haplotype diversity reached 0.99999 discrimination capacity match probability were 0.9956 0.0011, respectively. gene values ranged 0.3942 at DYS438 to 0.9607 DYS385a/b. Population differentiation within 10 Han subpopulations evaluated by RST...
Ancestry informative markers are genetic that show distinct divergences among different populations. These can be utilized to discern population substructures and estimate the ancestral origins of unknown individuals. Previously, we developed a multiplex system 30 ancestry single nucleotide polymorphism (AISNP) loci facilitate inferences in continental In current study, first compared resolutions AISNPs other previously reported AISNP panels for African, European, East Asian, South Asian...
The genetic polymorphisms of diallelic deletion/insertion polymorphic (DIP) loci in the Shaanxi Han population are still not clearly characterized. Herein, allele frequencies and forensic application efficiencies for 30 DIP were investigated 506 unrelated healthy individuals from Chinese province. Based on data same loci, differentiations, hierarchical clustering relationships architectures among other 50 populations further dissected through bioinformatics analyses. Results indicated that...
Abstract In recent years, insertion/deletion (InDel) markers became a promising and useful supporting tool in forensic identification cases biogeographic research field. this study, 30 InDel loci were explored to reveal the genetic diversities relationships between Chinese Xinjiang Hui group 24 previously studied populations using varies methods such as statistical parameter analysis, phylogenetic reconstruction, STRUCTURE multi-dimensional scaling, principal component analysis. The observed...