A5035841382- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Immune Response and Inflammation
- Calcium signaling and nucleotide metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Escherichia coli research studies
- Geological and Tectonic Studies in Latin America
- Soil Moisture and Remote Sensing
- Microbial Community Ecology and Physiology
- Microbial metabolism and enzyme function
- Geophysical Methods and Applications
- Infrared Thermography in Medicine
- Bacteriophages and microbial interactions
- Toxin Mechanisms and Immunotoxins
- interferon and immune responses
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Natural Antidiabetic Agents Studies
- Microbial infections and disease research
- Cell Adhesion Molecules Research
- Biochemical and Molecular Research
- Pharmacology and Obesity Treatment
- Immune cells in cancer
- Listeria monocytogenes in Food Safety
- Phytochemicals and Antioxidant Activities
Hospital for Sick Children
2020-2022
Universidad Nacional de Córdoba
2017-2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2021
Research Centre in Biological Chemistry of Córdoba
2020-2021
Trypanosoma cruzi is the causative agent of Chagas' disease, which affects approximately 10 million people living mainly in Latin America. Macrophages are one first cellular actors confronting invasion during T. infection, with their function depending on proper activation and polarization into distinct M1 M2 subtypes. Macrophage thought to be regulated not only by cytokines growth factors but also environmental signals. The metabolic checkpoint kinase mammalian target rapamycin (mTOR)...
Trypanosoma cruzi infection is associated with severe T cell unresponsiveness to antigens and mitogens characterized by decreased IL-2 synthesis. In addition, the acquisition of anergic phenotype correlated upregulation "gene related anergy in lymphocytes" (GRAIL) protein CD4 cells. We therefore sought examine role GRAIL proliferation during T. infection.Balb/c mice were infected intraperitoneally 500 blood-derived trypomastigotes Tulahuen strain, spleen cells from control non-infected or...
Abstract The type I interferon (IFN) signaling pathway has important functions in resistance to viral infection, with the downstream induction of stimulated genes (ISG) protecting host from virus entry, replication and spread. Listeria monocytogenes ( Lm ), a facultative intracellular foodborne pathogen, can exploit IFN response as part their pathogenic strategy, but molecular mechanisms involved remain unclear. Here we show that suppresses antibacterial activity phagocytes promote systemic...
Abstract Parastrephia lucida (Compositae), Tessaria absinthioides and Ephedra multiflora (Ephedraceae), three plant species from the Argentinean Puna (3600 m.a.s.l.) were selected for their anti‐inflammatory antioxidant properties to prepare mixtures evaluate use as nutraceuticals. Seven binary ternary herbal made of ethanol 20% extracts prepared (Mixtures A G), they analyzed effect on proinflammatory enzymes activity in two cellular systems cell free systems. Toxicity tests also carried...
The NOX2 NADPH oxidase (NOX2) produces reactive oxygen species to kill phagosome-confined bacteria. However, we previously showed that Listeria monocytogenes is able avoid the activity in phagosomes and escape cytosol. Thus, despite established role of limiting L. infection mice, underlying mechanisms this antibacterial remain unclear. In article, report controls systemic spread through modulation type I IFN response, which known be exploited by during infection. deficiency results increased...
In this column, we present a summary of the Third Remote Sensing Spring School at Teófilo Tabanera Space Center, Córdoba, Argentina, 10–21 September 2018, to support launch Satélite Argentino de Observación con Microondas (SAOCOM) 1A synthetic aperture radar (SAR) mission. Nearly all lecturers were IEEE Geoscience and Society (GRSS) senior members. More than 90 specialists in variety areas representing South Central American countries others around world present. Several international...